The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

AACS  -  acetoacetyl-CoA synthetase

Homo sapiens

Synonyms: ACSF1, Acetoacetyl-CoA synthetase, Acyl-CoA synthetase family member 1, FLJ12389, Protein sur-5 homolog, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of AACS

 

High impact information on AACS

  • In order to investigate the tissue distribution of AACS in human, cDNA encoding AACS was isolated from HepG2 cells [2].
  • Acetoacetyl-CoA synthetase (AACS, acetoacetate-CoA ligase, EC 6.2.1.16) is a ketone body-utilizing enzyme, the physiological role of which remains unclear yet in mammals, particularly has never been studied in human [2].
  • Amino acid sequence of human AACS deduced from the open reading frame showed high homology (89.3%) with that of rat AACS and much less homology (43.7%) with that of bacterial AACS [2].
  • The expression level of the AACS mRNA was high in kidney, heart and brain, but low in liver, and the expression profile of AACS in the human brain was quite similar to that of 3-hydroxy-3-methylglutaryl-CoA reductase [2].

References

  1. Purification and characterization of acetoacetyl-CoA synthetase from Zoogloea ramigera I-16-M. Fukui, T., Ito, M., Tomita, K. Eur. J. Biochem. (1982) [Pubmed]
  2. Expression of acetoacetyl-CoA synthetase, a novel cytosolic ketone body-utilizing enzyme, in human brain. Ohgami, M., Takahashi, N., Yamasaki, M., Fukui, T. Biochem. Pharmacol. (2003) [Pubmed]
 
WikiGenes - Universities