Gene Review:
BNIP3 - BCL2/adenovirus E1B 19kDa interacting...
Homo sapiens
Synonyms:
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3, NIP3, Nip3
- HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Sowter, H.M., Ratcliffe, P.J., Watson, P., Greenberg, A.H., Harris, A.L. Cancer Res. (2001)
- Paeoniae Radix, a Chinese herbal extract, inhibit hepatoma cells growth by inducing apoptosis in a p53 independent pathway. Lee, S.M., Li, M.L., Tse, Y.C., Leung, S.C., Lee, M.M., Tsui, S.K., Fung, K.P., Lee, C.Y., Waye, M.M. Life Sci. (2002)
- Silencing of the hypoxia-inducible cell death protein BNIP3 in pancreatic cancer. Okami, J., Simeone, D.M., Logsdon, C.D. Cancer Res. (2004)
- Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb. Li, Y., Wang, Y., Kim, E., Beemiller, P., Wang, C.Y., Swanson, J., You, M., Guan, K.L. J. Biol. Chem. (2007)
- BNIP3 as a progression marker in primary human breast cancer; opposing functions in in situ versus invasive cancer. Tan, E.Y., Campo, L., Han, C., Turley, H., Pezzella, F., Gatter, K.C., Harris, A.L., Fox, S.B. Clin. Cancer Res. (2007)
- cDNA array reveals mechanosensitive genes in chondrocytic cells under hydrostatic pressure. Sironen, R.K., Karjalainen, H.M., Elo, M.A., Kaarniranta, K., Törrönen, K., Takigawa, M., Helminen, H.J., Lammi, M.J. Biochim. Biophys. Acta (2002)
- The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis. Chen, G., Ray, R., Dubik, D., Shi, L., Cizeau, J., Bleackley, R.C., Saxena, S., Gietz, R.D., Greenberg, A.H. J. Exp. Med. (1997)
- Adenovirus E1B-19K/BCL-2 interacting protein BNIP3 contains a BH3 domain and a mitochondrial targeting sequence. Yasuda, M., Theodorakis, P., Subramanian, T., Chinnadurai, G. J. Biol. Chem. (1998)
- Intestinal and hepatic expression of BNIP3 in necrotizing enterocolitis: regulation by nitric oxide and peroxynitrite. Zamora, R., Vodovotz, Y., Betten, B., Wong, C., Zuckerbraun, B., Gibson, K.F., Ford, H.R. Am. J. Physiol. Gastrointest. Liver Physiol. (2005)
- Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells. Daido, S., Kanzawa, T., Yamamoto, A., Takeuchi, H., Kondo, Y., Kondo, S. Cancer Res. (2004)
- BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3. Yasuda, M., Han, J.W., Dionne, C.A., Boyd, J.M., Chinnadurai, G. Cancer Res. (1999)
- Cloning of BNIP3h, a member of proapoptotic BNIP3 family genes. Farooq, M., Kim, Y., Im, S., Chung, E., Hwang, S., Sohn, M., Kim, M., Kim, J. Exp. Mol. Med. (2001)
- BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore. Vande Velde, C., Cizeau, J., Dubik, D., Alimonti, J., Brown, T., Israels, S., Hakem, R., Greenberg, A.H. Mol. Cell. Biol. (2000)
- CD47 and the 19 kDa interacting protein-3 (BNIP3) in T cell apoptosis. Lamy, L., Ticchioni, M., Rouquette-Jazdanian, A.K., Samson, M., Deckert, M., Greenberg, A.H., Bernard, A. J. Biol. Chem. (2003)
- BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF. Kothari, S., Cizeau, J., McMillan-Ward, E., Israels, S.J., Bailes, M., Ens, K., Kirshenbaum, L.A., Gibson, S.B. Oncogene (2003)
- BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites. Ray, R., Chen, G., Vande Velde, C., Cizeau, J., Park, J.H., Reed, J.C., Gietz, R.D., Greenberg, A.H. J. Biol. Chem. (2000)
- Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis. Erkan, M., Kleeff, J., Esposito, I., Giese, T., Ketterer, K., Büchler, M.W., Giese, N.A., Friess, H. Oncogene (2005)
- Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer. Murai, M., Toyota, M., Suzuki, H., Satoh, A., Sasaki, Y., Akino, K., Ueno, M., Takahashi, F., Kusano, M., Mita, H., Yanagihara, K., Endo, T., Hinoda, Y., Tokino, T., Imai, K. Clin. Cancer Res. (2005)
- Regulation of Bnip3 death pathways by calcium, phosphorylation, and hypoxia-reoxygenation. Graham, R.M., Thompson, J.W., Wei, J., Bishopric, N.H., Webster, K.A. Antioxid. Redox Signal. (2007)
- Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Bruick, R.K. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Upregulation of BNIP3 promotes apoptosis of lung cancer cells that were induced by p53. Yan, J., Yun, H., Yang, Y., Jing, B., Feng, C., Song-bin, F. Biochem. Biophys. Res. Commun. (2006)
- Selective silencing of the hypoxia-inducible factor 1 target gene BNIP3 by histone deacetylation and methylation in colorectal cancer. Bacon, A.L., Fox, S., Turley, H., Harris, A.L. Oncogene (2007)
- Hypoxia induces the expression of the pro-apoptotic gene BNIP3. Guo, K., Searfoss, G., Krolikowski, D., Pagnoni, M., Franks, C., Clark, K., Yu, K.T., Jaye, M., Ivashchenko, Y. Cell Death Differ. (2001)