Disease relevance of Magmas

• During embryogenesis, elevated Magmas was observed in several structures, including heart, liver, notochord, choroid plexus, cervical ganglion, and nasal mucosa [1].

High impact information on Magmas

• CONCLUSION: Magmas is a mitochondrial protein involved in GM-CSF signal transduction [2].
• Analysis of the amino acid sequence of Magmas showed it contained a mitochondrial signal peptide, but not any other known functional domains [2].
• Magmas is a protein that is involved in GM-CSF signaling in a myeloid cell line [1].
• Developmental expression of Magmas in murine tissues and its co-expression with the GM-CSF receptor [1].
• Muscle, pancreas, intestinal mucosa, and testes were among the adult tissues with high Magmas expression [1].

Biological context of Magmas

• Identification and characterization of Magmas, a novel mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal transduction [2].
• Significant genetic diversity in Magmas was observed from kingdom specific amino acid signatures, the presence of predicted signal peptides that target the protein to other intracellular locations besides the mitochondria, and the detection of multiple isoforms in higher animals [3].

Anatomical context of Magmas

• Magmas is a nuclear encoded protein found in the mitochondria of mammalian cells [3].

References