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SRP14  -  signal recognition particle 14kDa...

Homo sapiens

Synonyms: 18 kDa Alu RNA-binding protein, ALURBP, MGC14326, Signal recognition particle 14 kDa protein
 
 
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High impact information on SRP14

  • The Alu domain of the mammalian signal recognition particle (SRP) comprises the heterodimer of proteins SRP9 and SRP14 bound to the 5' and 3' terminal sequences of SRP RNA [1].
  • Moreover, the presence of the trinucleotide repeat in SRP14 DNA and the corresponding C-terminal tail in SRP14 are associated with a significant increase in SRP14 polypeptide and Alu RNA-binding activity [2].
  • In anthropoids, the active SRP14 gene acquired a GCA trinucleotide repeat in its 3'-coding region that produces SRP14 polypeptides with extended C-terminal tails [2].
  • Here, we show that in early anthropoids, the gene encoding SRP14 Alu RNA-binding protein was duplicated and that SRP14-homologous sequences currently reside on different human chromosomes [2].
  • Using protein cross-linking, we provide experimental evidence that the Alu binding protein SRP14 is in close physical proximity of several ribosomal proteins in functional complexes [3].
 

Biological context of SRP14

 

Other interactions of SRP14

  • Although SRP9 proteins are the same size in both rodent and primate cells, SRP14 subunits are generally larger in primate cells [5].

References

 
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