Gene Review:
SRPK1 - SRSF protein kinase 1
Homo sapiens
Synonyms:
SFRS protein kinase 1, SFRSK1, SR-protein-specific kinase 1, Serine/arginine-rich protein-specific kinase 1
- Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein. Daub, H., Blencke, S., Habenberger, P., Kurtenbach, A., Dennenmoser, J., Wissing, J., Ullrich, A., Cotten, M. J. Virol. (2002)
- SKY1 is involved in cisplatin-induced cell kill in Saccharomyces cerevisiae, and inactivation of its human homologue, SRPK1, induces cisplatin resistance in a human ovarian carcinoma cell line. Schenk, P.W., Boersma, A.W., Brandsma, J.A., den Dulk, H., Burger, H., Stoter, G., Brouwer, J., Nooter, K. Cancer Res. (2001)
- Serological identification of adult T-cell leukaemia-associated antigens. Hishizawa, M., Imada, K., Sakai, T., Ueda, M., Hori, T., Uchiyama, T. Br. J. Haematol. (2005)
- A serine kinase regulates intracellular localization of splicing factors in the cell cycle. Gui, J.F., Lane, W.S., Fu, X.D. Nature (1994)
- Interplay between SRPK and Clk/Sty kinases in phosphorylation of the splicing factor ASF/SF2 is regulated by a docking motif in ASF/SF2. Ngo, J.C., Chakrabarti, S., Ding, J.H., Velazquez-Dones, A., Nolen, B., Aubol, B.E., Adams, J.A., Fu, X.D., Ghosh, G. Mol. Cell (2005)
- Human autoimmune sera as molecular probes for the identification of an autoantigen kinase signaling pathway. Kamachi, M., Le, T.M., Kim, S.J., Geiger, M.E., Anderson, P., Utz, P.J. J. Exp. Med. (2002)
- ICP27 interacts with SRPK1 to mediate HSV splicing inhibition by altering SR protein phosphorylation. Sciabica, K.S., Dai, Q.J., Sandri-Goldin, R.M. EMBO J. (2003)
- SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells. Wang, H.Y., Lin, W., Dyck, J.A., Yeakley, J.M., Songyang, Z., Cantley, L.C., Fu, X.D. J. Cell Biol. (1998)
- Cloning and characterization of an alternatively spliced form of SR protein kinase 1 that interacts specifically with scaffold attachment factor-B. Nikolakaki, E., Kohen, R., Hartmann, A.M., Stamm, S., Georgatsou, E., Giannakouros, T. J. Biol. Chem. (2001)
- Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2), specific for the SR family of splicing factors in mouse and human chromosomes. Wang, H.Y., Arden, K.C., Bermingham, J.R., Viars, C.S., Lin, W., Boyer, A.D., Fu, X.D. Genomics (1999)
- Regulated cellular partitioning of SR protein-specific kinases in mammalian cells. Ding, J.H., Zhong, X.Y., Hagopian, J.C., Cruz, M.M., Ghosh, G., Feramisco, J., Adams, J.A., Fu, X.D. Mol. Biol. Cell (2006)
- SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1. Papoutsopoulou, S., Nikolakaki, E., Chalepakis, G., Kruft, V., Chevaillier, P., Giannakouros, T. Nucleic Acids Res. (1999)
- Targeting the RNA splicing machinery as a novel treatment strategy for pancreatic carcinoma. Hayes, G.M., Carrigan, P.E., Beck, A.M., Miller, L.J. Cancer Res. (2006)
- Bleomycin resistance in mammalian cells expressing a genetic suppressor element derived from the SRPK1 gene. Sanz, G., Mir, L., Jacquemin-Sablon, A. Cancer Res. (2002)
- Protein kinase CK2 phosphorylates and activates the SR protein-specific kinase 1. Mylonis, I., Giannakouros, T. Biochem. Biophys. Res. Commun. (2003)
- Synthesis of selective SRPK-1 inhibitors: novel tricyclic quinoxaline derivatives. Székelyhidi, Z., Pató, J., Wáczek, F., Bánhegyi, P., Hegymegi-Barakonyi, B., Erös, D., Mészáros, G., Hollósy, F., Hafenbradl, D., Obert, S., Klebl, B., Kéri, G., Orfi, L. Bioorg. Med. Chem. Lett. (2005)
- SR protein kinase 1 is resilient to inactivation. Ngo, J.C., Gullingsrud, J., Giang, K., Yeh, M.J., Fu, X.D., Adams, J.A., McCammon, J.A., Ghosh, G. Structure (2007)
- SRPK1 and LBR protein kinases show identical substrate specificities. Papoutsopoulou, S., Nikolakaki, E., Giannakouros, T. Biochem. Biophys. Res. Commun. (1999)
- Systematic genome-wide annotation of spliceosomal proteins reveals differential gene family expansion. Barbosa-Morais, N.L., Carmo-Fonseca, M., Aparício, S. Genome Res. (2006)
- Expression analysis of genes involved in oxaliplatin response and development of oxaliplatin-resistant HT29 colon cancer cells. Plasencia, C., Martínez-Balibrea, E., Martinez-Cardús, A., Quinn, D.I., Abad, A., Neamati, N. Int. J. Oncol. (2006)
- Genomic structure and gene order of swine chromosome 7q1.1-->q1.2. Tanaka, M., Suzuki, K., Morozumi, T., Kobayashi, E., Matsumoto, T., Domukai, M., Eguchi-Ogawa, T., Shinkai, H., Awata, T., Uenishi, H. Anim. Genet. (2006)
- Resistance to platinum-containing chemotherapy in testicular germ cell tumors is associated with downregulation of the protein kinase SRPK1. Schenk, P.W., Stoop, H., Bokemeyer, C., Mayer, F., Stoter, G., Oosterhuis, J.W., Wiemer, E., Looijenga, L.H., Nooter, K. Neoplasia (2004)