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Gene Review

Srpr  -  signal recognition particle receptor...

Mus musculus

Synonyms: 1300011P19Rik, D11Mgi27, DP-alpha, Docking protein alpha, SR-alpha, ...
 
 
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High impact information on Srpr

  • Recent work has shown that SR alpha is a GTP-binding protein and that GTP is required for the release of SRP from the signal sequence and the ribosome on targeting to the endoplasmic reticulum membrane [1].
  • The latter plasmid contains the rat TGF-alpha cDNA under the transcriptional control of the SR alpha promoter [2].
  • The SR alpha promoter expression vector containing BHV-1 gIII gene was transfected into COS-7 cells [3].
  • The first 125 bp downregulated the expression of MCP molecules in combination with not only beta-actin, but also SR alpha, promoter [4].

References

  1. Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle. Bernstein, H.D., Poritz, M.A., Strub, K., Hoben, P.J., Brenner, S., Walter, P. Nature (1989) [Pubmed]
  2. In vitro and in vivo acceleration of the neoplastic phenotype of a low-tumorigenicity rat bladder carcinoma cell line by transfected transforming growth factor-alpha. Kawamata, H., Kameyama, S., Oyasu, R. Mol. Carcinog. (1994) [Pubmed]
  3. Hemadsorptive activity of transfected COS-7 cells expressing BHV-1 glycoprotein gIII. Okazaki, K., Kanno, T., Kiriya, S., Honda, E., Kono, Y. Virology (1993) [Pubmed]
  4. The regulation of membrane cofactor protein (CD46) expression by the 3' untranslated region in transgenic mice. Miyagawa, S., Mikata, S., Tanaka, H., Ikawa, M., Kominami, K., Seya, T., Nishimune, Y., Shirakura, R., Okabe, M. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
 

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