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Gene Review: 

Slc39a8  -  solute carrier family 39 (metal ion...

Mus musculus

Synonyms: 4933419D20Rik, AA986696, BIGM103, Solute carrier family 39 member 8, ZIP-8, ...
 
 
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Disease relevance of Slc39a8

  • SNP analysis of this region from two sensitive and two resistant inbred strains demonstrated a 400-kb haplotype block consistent with the Cd-induced toxicity phenotype; in this region is the Slc39a8 gene encoding a member of the solute-carrier superfamily [1].
 

High impact information on Slc39a8

  • Members of our laboratory recently identified the ZIP8 transporter protein, encoded by the mouse Slc39a8 gene, to be responsible for genetic differences in response to cadmium damage of the testis [2].
 

Anatomical context of Slc39a8

References

  1. Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis. Dalton, T.P., He, L., Wang, B., Miller, M.L., Jin, L., Stringer, K.F., Chang, X., Baxter, C.S., Nebert, D.W. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: characterization of transporter properties. He, L., Girijashanker, K., Dalton, T.P., Reed, J., Li, H., Soleimani, M., Nebert, D.W. Mol. Pharmacol. (2006) [Pubmed]
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