Gene Review:
STAT1 - signal transducer and activator of...
Homo sapiens
Synonyms:
CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, ...
- Hepatitis C virus expression suppresses interferon signaling by degrading STAT1. Lin, W., Choe, W.H., Hiasa, Y., Kamegaya, Y., Blackard, J.T., Schmidt, E.V., Chung, R.T. Gastroenterology (2005)
- A human cytomegalovirus antagonist of type I IFN-dependent signal transducer and activator of transcription signaling. Paulus, C., Krauss, S., Nevels, M. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Prolonged STAT1 activation related to the growth arrest of malignant lymphoma cells by interferon-alpha. Grimley, P.M., Fang, H., Rui, H., Petricoin, E.F., Ray, S., Dong, F., Fields, K.H., Hu, R., Zoon, K.C., Audet, S., Beeler, J. Blood (1998)
- STAT1 mediates differentiation of chronic lymphocytic leukemia cells in response to Bryostatin 1. Battle, T.E., Frank, D.A. Blood (2003)
- Interferon-alpha resistance in a cutaneous T-cell lymphoma cell line is associated with lack of STAT1 expression. Sun, W.H., Pabon, C., Alsayed, Y., Huang, P.P., Jandeska, S., Uddin, S., Platanias, L.C., Rosen, S.T. Blood (1998)
- Alteration of transcription factors NF-kappaB and STAT1 in Alzheimer's disease brains. Kitamura, Y., Shimohama, S., Ota, T., Matsuoka, Y., Nomura, Y., Taniguchi, T. Neurosci. Lett. (1997)
- Transcriptional control of the cell cycle in mammary gland development and tumorigenesis. Coletta, R.D., Jedlicka, P., Gutierrez-Hartmann, A., Ford, H.L. Journal of mammary gland biology and neoplasia. (2004)
- Interaction of brain-type creatine kinase with its transition state analog: kinetics of inhibition and conformational changes. Grossman, S.H., Garcia-Rubio, L.H. J. Enzym. Inhib. (1987)
- Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation. Mellado, M., Rodríguez-Frade, J.M., Mañes, S., Martínez-A, C. Annu. Rev. Immunol. (2001)
- Negative regulation of cytokine signaling pathways. Yasukawa, H., Sasaki, A., Yoshimura, A. Annu. Rev. Immunol. (2000)
- Jaks and STATs: biological implications. Leonard, W.J., O'Shea, J.J. Annu. Rev. Immunol. (1998)
- The JAK-STAT pathway at twenty. Stark, G.R., Darnell JE, J.r. Immunity. (2012)
- JAK signaling globally counteracts heterochromatic gene silencing. Shi, S., Calhoun, H.C., Xia, F., Li, J., Le, L., Li, W.X. Nat. Genet. (2006)
- Regulation of STAT signaling by acetylation. Zhuang, S. Cell. Signal. (2013)
- Arginine methylation of STAT1: a reassessment. Meissner, T., Krause, E., Lödige, I., Vinkemeier, U. Cell (2004)
- STAT1: a modulator of chemotherapy-induced apoptosis. Thomas, M., Finnegan, C.E., Rogers, K.M., Purcell, J.W., Trimble, A., Johnston, P.G., Boland, M.P. Cancer Res. (2004)
- Inhibition of IFN-gamma-mediated inducible nitric oxide synthase induction by the peroxisome proliferator-activated receptor gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, involves inhibition of the upstream Janus kinase/STAT1 signaling pathway. Chen, C.W., Chang, Y.H., Tsi, C.J., Lin, W.W. J. Immunol. (2003)
- The induction and activation of STAT1 by all-trans-retinoic acid are mediated by RAR beta signaling pathways in breast cancer cells. Shang, Y., Baumrucker, C.R., Green, M.H. Oncogene (1999)
- A soluble factor(s) secreted from CD8(+) T lymphocytes inhibits human immunodeficiency virus type 1 replication through STAT1 activation. Chang, T.L., Mosoian, A., Pine, R., Klotman, M.E., Moore, J.P. J. Virol. (2002)
- Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription. Mowen, K.A., Tang, J., Zhu, W., Schurter, B.T., Shuai, K., Herschman, H.R., David, M. Cell (2001)
- Are STATS arginine-methylated?. Komyod, W., Bauer, U.M., Heinrich, P.C., Haan, S., Behrmann, I. J. Biol. Chem. (2005)
- Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1. Chin, Y.E., Kitagawa, M., Su, W.C., You, Z.H., Iwamoto, Y., Fu, X.Y. Science (1996)
- Global changes in STAT target selection and transcription regulation upon interferon treatments. Hartman, S.E., Bertone, P., Nath, A.K., Royce, T.E., Gerstein, M., Weissman, S., Snyder, M. Genes Dev. (2005)
- Inhibition of IFN-gamma signaling by an Epstein-Barr virus immediate-early protein. Morrison, T.E., Mauser, A., Wong, A., Ting, J.P., Kenney, S.C. Immunity (2001)
- Septic sera induces apoptosis and DNA fragmentation factor 40 activation in fibroblasts. Brabant, D., Michael, P., Bleiblo, F., Saleh, M., Narain, R., Tai, T.C., Ramana, C.V., Parrillo, J.E., Kumar, A., Kumar, A. Biochem. Biophys. Res. Commun. (2011)
- Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation. Gurney, A.L., Wong, S.C., Henzel, W.J., de Sauvage, F.J. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Human T-cell leukemia virus type 2 induces survival and proliferation of CD34(+) TF-1 cells through activation of STAT1 and STAT5 by secretion of interferon-gamma and granulocyte macrophage-colony-stimulating factor. Bovolenta, C., Pilotti, E., Mauri, M., Turci, M., Ciancianaini, P., Fisicaro, P., Bertazzoni, U., Poli, G., Casoli, C. Blood (2002)
- Differential roles of STAT1alpha and STAT1beta in fludarabine-induced cell cycle arrest and apoptosis in human B cells. Baran-Marszak, F., Feuillard, J., Najjar, I., Le Clorennec, C., Béchet, J.M., Dusanter-Fourt, I., Bornkamm, G.W., Raphaël, M., Fagard, R. Blood (2004)
- Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis. Chin, Y.E., Kitagawa, M., Kuida, K., Flavell, R.A., Fu, X.Y. Mol. Cell. Biol. (1997)
- The membrane-distal cytoplasmic region of human granulocyte colony-stimulating factor receptor is required for STAT3 but not STAT1 homodimer formation. de Koning, J.P., Dong, F., Smith, L., Schelen, A.M., Barge, R.M., van der Plas, D.C., Hoefsloot, L.H., Löwenberg, B., Touw, I.P. Blood (1996)
- PKCepsilon is a permissive link in integrin-dependent IFN-gamma signalling that facilitates JAK phosphorylation of STAT1. Ivaska, J., Bosca, L., Parker, P.J. Nat. Cell Biol. (2003)
- p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons. Goh, K.C., Haque, S.J., Williams, B.R. EMBO J. (1999)
- Arginine/lysine-rich structural element is involved in interferon-induced nuclear import of STATs. Melen, K., Kinnunen, L., Julkunen, I. J. Biol. Chem. (2001)
- Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl. Carlesso, N., Frank, D.A., Griffin, J.D. J. Exp. Med. (1996)
- Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes. Ouchi, T., Lee, S.W., Ouchi, M., Aaronson, S.A., Horvath, C.M. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. Li, X., Leung, S., Kerr, I.M., Stark, G.R. Mol. Cell. Biol. (1997)
- The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors. Pang, Q., Fagerlie, S., Christianson, T.A., Keeble, W., Faulkner, G., Diaz, J., Rathbun, R.K., Bagby, G.C. Mol. Cell. Biol. (2000)
- Construction of a novel oligonucleotide array-based transcription factor interaction assay platform and its uses for profiling STAT1 cofactors in mouse fibroblast cells. Zeng, L., Sun, Y., Xie, L., Wei, L., Ren, Y., Zhao, J., Qin, W., Mitchelson, K., Cheng, J. Proteomics. (2013)
- A Kaposi's sarcoma-associated herpesvirus-encoded cytokine homolog (vIL-6) activates signaling through the shared gp130 receptor subunit. Molden, J., Chang, Y., You, Y., Moore, P.S., Goldsmith, M.A. J. Biol. Chem. (1997)
- Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins. Shuai, K., Ziemiecki, A., Wilks, A.F., Harpur, A.G., Sadowski, H.B., Gilman, M.Z., Darnell, J.E. Nature (1993)
- Paramyxoviridae use distinct virus-specific mechanisms to circumvent the interferon response. Young, D.F., Didcock, L., Goodbourn, S., Randall, R.E. Virology (2000)
- Differential substrate recognition capabilities of Janus family protein tyrosine kinases within the interleukin 2 receptor (IL2R) system: Jak3 as a potential molecular target for treatment of leukemias with a hyperactive Jak-Stat signaling machinery. Witthuhn, B.A., Williams, M.D., Kerawalla, H., Uckun, F.M. Leuk. Lymphoma (1999)
- Cytokine signaling: STATS in plasma membrane rafts. Sehgal, P.B., Guo, G.G., Shah, M., Kumar, V., Patel, K. J. Biol. Chem. (2002)
- The C-terminal half-fragment of the Sendai virus C protein prevents the gamma-activated factor from binding to a gamma-activated sequence site. Gotoh, B., Komatsu, T., Takeuchi, K., Yokoo, J. Virology (2003)
- The presence of STAT1-positive tumor-associated macrophages and their relation to outcome in patients with follicular lymphoma. Alvaro, T., Lejeune, M., Camacho, F.I., Salvad??, M.T., S??nchez, L., Garc??a, J.F., Lopez, C., Ja??n, J., Bosch, R., Pons, L.E., Bellas, C., Piris, M.A. Haematologica (2006)
- PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity. Liu, B., Mink, S., Wong, K.A., Stein, N., Getman, C., Dempsey, P.W., Wu, H., Shuai, K. Nat. Immunol. (2004)
- Prolactin activates Stat1 but does not antagonize Stat1 activation and growth inhibition by type I interferons in human breast cancer cells. Schaber, J.D., Fang, H., Xu, J., Grimley, P.M., Rui, H. Cancer Res. (1998)
- Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation. Gerhartz, C., Heesel, B., Sasse, J., Hemmann, U., Landgraf, C., Schneider-Mergener, J., Horn, F., Heinrich, P.C., Graeve, L. J. Biol. Chem. (1996)
- Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiency. Dupuis, S., Jouanguy, E., Al-Hajjar, S., Fieschi, C., Al-Mohsen, I.Z., Al-Jumaah, S., Yang, K., Chapgier, A., Eidenschenk, C., Eid, P., Al Ghonaium, A., Tufenkeji, H., Frayha, H., Al-Gazlan, S., Al-Rayes, H., Schreiber, R.D., Gresser, I., Casanova, J.L. Nat. Genet. (2003)
- Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS. Hong, F., Jaruga, B., Kim, W.H., Radaeva, S., El-Assal, O.N., Tian, Z., Nguyen, V.A., Gao, B. J. Clin. Invest. (2002)
- Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes. Beadling, C., Guschin, D., Witthuhn, B.A., Ziemiecki, A., Ihle, J.N., Kerr, I.M., Cantrell, D.A. EMBO J. (1994)
- Inhibition of Stat1-mediated gene activation by PIAS1. Liu, B., Liao, J., Rao, X., Kushner, S.A., Chung, C.D., Chang, D.D., Shuai, K. Proc. Natl. Acad. Sci. U.S.A. (1998)
- The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma. Savage, K.J., Monti, S., Kutok, J.L., Cattoretti, G., Neuberg, D., De Leval, L., Kurtin, P., Dal Cin, P., Ladd, C., Feuerhake, F., Aguiar, R.C., Li, S., Salles, G., Berger, F., Jing, W., Pinkus, G.S., Habermann, T., Dalla-Favera, R., Harris, N.L., Aster, J.C., Golub, T.R., Shipp, M.A. Blood (2003)