Gene Review:
TACR3 - tachykinin receptor 3
Homo sapiens
Synonyms:
HH11, NK-3 receptor, NK-3R, NK3R, NKR, ...
Brylla,
Aust,
Geyer,
Uckermann,
Löffler,
Spanel-Borowski,
Sarau,
Griswold,
Potts,
Foley,
Schmidt,
Webb,
Martin,
Brawner,
Elshourbagy,
Medhurst,
Giardina,
Hay,
King,
Sanger,
Menzies,
McKee,
Corbett,
Sanger,
Janecka,
Poels,
Fichna,
Studzian,
Vanden Broeck,
De Schepper,
De Winter,
Seerden,
Herman,
Pelckmans,
De Man,
Krause,
Staveteig,
Mentzer,
Schmidt,
Tucker,
Brodbeck,
Bu,
Karpitskiy,
Mitolo-Chieppa,
Mansi,
Nacci,
De Salvia,
Montagnani,
Potenza,
Rinaldi,
Lerro,
Siro-Brigiani,
Mitolo,
Rinaldi,
Altomare,
Memeo,
- Idiopathic chronic constipation: tachykinins as cotransmitters in colonic contraction. Mitolo-Chieppa, D., Mansi, G., Nacci, C., De Salvia, M.A., Montagnani, M., Potenza, M.A., Rinaldi, R., Lerro, G., Siro-Brigiani, G., Mitolo, C.I., Rinaldi, M., Altomare, D.F., Memeo, V. Eur. J. Clin. Invest. (2001)
- Expression of NK-1 and NK-3 tachykinin receptors in pancreatic acinar cells after acute experimental pancreatitis in rats. Broccardo, M., Linari, G., Agostini, S., Amadoro, G., Carpino, F., Ciotti, M.T., Petrella, C., Petrozza, V., Severini, C., Improta, G. Am. J. Physiol. Gastrointest. Liver Physiol. (2006)
- Neurokinin NK1 and NK3 receptors as targets for drugs to treat gastrointestinal motility disorders and pain. Sanger, G.J. Br. J. Pharmacol. (2004)
- Effect of a selective and potent central nervous system penetrant, neurokinin-3 receptor antagonist (SB-222200), on cisplatin-induced emesis in the ferret. King, A.G., Sanger, G.J. Neurosci. Lett. (2005)
- Peripheral tachykinin receptors as potential therapeutic targets in visceral diseases. Lecci, A., Maggi, C.A. Expert Opin. Ther. Targets (2003)
- Neurokinin peptides and neurokinin receptors as potential therapeutic intervention targets of basal ganglia in the prevention and treatment of Parkinson's disease. Chen, L.W., Yung, K.K., Chan, Y.S. Current drug targets. (2004)
- Short-term rhythms in the performance of a simple motor task. Gopher, D., Lavie, P. Journal of motor behavior. (1980)
- Crystal structure of a lectin-like natural killer cell receptor bound to its MHC class I ligand. Tormo, J., Natarajan, K., Margulies, D.H., Mariuzza, R.A. Nature (1999)
- Different binding epitopes on the NK1 receptor for substance P and non-peptide antagonist. Gether, U., Johansen, T.E., Snider, R.M., Lowe, J.A., Nakanishi, S., Schwartz, T.W. Nature (1993)
- Enhancement of class II-restricted T cell responses by costimulatory NK receptors for class I MHC proteins. Mandelboim, O., Davis, D.M., Reyburn, H.T., Valés-Gómez, M., Sheu, E.G., Pazmany, L., Strominger, J.L. Science (1996)
- Structure of the Epstein-Barr virus gp42 protein bound to the MHC class II receptor HLA-DR1. Mullen, M.M., Haan, K.M., Longnecker, R., Jardetzky, T.S. Mol. Cell (2002)
- Intercellular transfer and supramolecular organization of human leukocyte antigen C at inhibitory natural killer cell immune synapses. Carlin, L.M., Eleme, K., McCann, F.E., Davis, D.M. J. Exp. Med. (2001)
- Functional expression of a novel human neurokinin-3 receptor homolog that binds [3H]senktide and [125I-MePhe7]neurokinin B, and is responsive to tachykinin peptide agonists. Krause, J.E., Staveteig, P.T., Mentzer, J.N., Schmidt, S.K., Tucker, J.B., Brodbeck, R.M., Bu, J.Y., Karpitskiy, V.V. Proc. Natl. Acad. Sci. U.S.A. (1997)
- The primary structure and gene organization of human substance P and neuromedin K receptors. Takahashi, K., Tanaka, A., Hara, M., Nakanishi, S. Eur. J. Biochem. (1992)
- Phylogeny of tachykinin receptor localization in the vertebrate central nervous system: apparent absence of neurokinin-2 and neurokinin-3 binding sites in the human brain. Dietl, M.M., Palacios, J.M. Brain Res. (1991)
- Structural motifs encoded by individual exons of the human neurokinin-1 receptor gene interact differentially with selective agonists and antagonists. Tian, Y., Wu, L.H., Pu, Y., Huang, C.C., Chung, F.Z. J. Neurochem. (1996)
- mRNA expression of tachykinins and tachykinin receptors in different human tissues. Pinto, F.M., Almeida, T.A., Hernandez, M., Devillier, P., Advenier, C., Candenas, M.L. Eur. J. Pharmacol. (2004)
- Substance P (SP) mediates production of stem cell factor and interleukin-1 in bone marrow stroma: potential autoregulatory role for these cytokines in SP receptor expression and induction. Rameshwar, P., Gascón, P. Blood (1995)
- Nonpeptide tachykinin receptor antagonists. II. Pharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potent and selective NK-3 receptor antagonist. Sarau, H.M., Griswold, D.E., Bush, B., Potts, W., Sandhu, P., Lundberg, D., Foley, J.J., Schmidt, D.B., Webb, E.F., Martin, L.D., Legos, J.J., Whitmore, R.G., Barone, F.C., Medhurst, A.D., Luttmann, M.A., Giardina, G.A., Hay, D.W. J. Pharmacol. Exp. Ther. (2000)
- Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist. Sarau, H.M., Griswold, D.E., Potts, W., Foley, J.J., Schmidt, D.B., Webb, E.F., Martin, L.D., Brawner, M.E., Elshourbagy, N.A., Medhurst, A.D., Giardina, G.A., Hay, D.W. J. Pharmacol. Exp. Ther. (1997)
- Coexpression of preprotachykinin A and B transcripts in the bovine corpus luteum and evidence for functional neurokinin receptor activity in luteal endothelial cells and ovarian macrophages. Brylla, E., Aust, G., Geyer, M., Uckermann, O., Löffler, S., Spanel-Borowski, K. Regul. Pept. (2005)
- Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 2. Identification of (S)-N-(1-phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide (SB 223412). Giardina, G.A., Raveglia, L.F., Grugni, M., Sarau, H.M., Farina, C., Medhurst, A.D., Graziani, D., Schmidt, D.B., Rigolio, R., Luttmann, M., Cavagnera, S., Foley, J.J., Vecchietti, V., Hay, D.W. J. Med. Chem. (1999)
- Stepwise modulation of neurokinin-3 and neurokinin-2 receptor affinity and selectivity in quinoline tachykinin receptor antagonists. Blaney, F.E., Raveglia, L.F., Artico, M., Cavagnera, S., Dartois, C., Farina, C., Grugni, M., Gagliardi, S., Luttmann, M.A., Martinelli, M., Nadler, G.M., Parini, C., Petrillo, P., Sarau, H.M., Scheideler, M.A., Hay, D.W., Giardina, G.A. J. Med. Chem. (2001)
- Characterization of NK3 receptors in rabbit isolated iris sphincter muscle. Medhurst, A.D., Parsons, A.A., Roberts, J.C., Hay, D.W. Br. J. Pharmacol. (1997)
- Molecular characterisation, expression and localisation of human neurokinin-3 receptor. Buell, G., Schulz, M.F., Arkinstall, S.J., Maury, K., Missotten, M., Adami, N., Talabot, F., Kawashima, E. FEBS Lett. (1992)
- Comparison of antagonist activity of spantide family at human neurokinin receptors measured by aequorin luminescence-based functional calcium assay. Janecka, A., Poels, J., Fichna, J., Studzian, K., Vanden Broeck, J. Regul. Pept. (2005)
- Differential alterations in tachykinin NK2 receptors in isolated colonic circular smooth muscle in inflammatory bowel disease and idiopathic chronic constipation. Menzies, J.R., McKee, R., Corbett, A.D. Regul. Pept. (2001)
- The role of tachykinins in circular muscle contractility of the murine ileum: a functional investigation. De Schepper, H.U., De Winter, B.Y., Seerden, T.C., Herman, A.G., Pelckmans, P.A., De Man, J.G. Autonomic neuroscience : basic & clinical. (2006)
- Substance P-induced cadherin expression and its signal transduction in a cloned human corneal epithelial cell line. Araki-Sasaki, K., Aizawa, S., Hiramoto, M., Nakamura, M., Iwase, O., Nakata, K., Sasaki, Y., Mano, T., Handa, H., Tano, Y. J. Cell. Physiol. (2000)
- Chromodacryorrhea and repetitive hind paw tapping: models of peripheral and central tachykinin NK1 receptor activation in gerbils. Bristow, L.J., Young, L. Eur. J. Pharmacol. (1994)
- Cobalt-mediated dimerization of the human natural killer cell inhibitory receptor. Fan, Q.R., Long, E.O., Wiley, D.C. J. Biol. Chem. (2000)
- Enhanced recognition of human NK receptors after influenza virus infection. Achdout, H., Arnon, T.I., Markel, G., Gonen-Gross, T., Katz, G., Lieberman, N., Gazit, R., Joseph, A., Kedar, E., Mandelboim, O. J. Immunol. (2003)