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TAF6  -  TAF6 RNA polymerase II, TATA box binding...

Homo sapiens

Synonyms: MGC:8964, RNA polymerase II TBP-associated factor subunit E, TAF(II)70, TAF(II)80, TAF2E, ...
 
 
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Disease relevance of TAF6

 

High impact information on TAF6

  • Furthermore, HFD-mediated interaction stimulated sequence-specific binding by TAF6 and TAF9 [2].
  • We also observed that N-CoR directly interacts with each of the basal factors, TFIIB and TAFII70, and can simultaneously interact with all three basal factors in a non-competitive manner [3].
  • Expression of TAFII70 RNA and protein during oogenesis and development of the amphibian Pleurodeles waltl [4].
  • TAFII70 protein, which is present in fertilized eggs and throughout development, progressively shows a lower level of expression starting from the neurula stage [4].
  • In this paper, we demonstrate that E2 proteins associate in vitro with several TAFs, in particular with TAFII250 and TAFII80 [5].
 

Biological context of TAF6

  • Both isoforms induce expression of the G2 arrest associated gene, GADD45a, but a novel protein-protein interaction was observed between TAFII70 (not TAFII80) and GADD45a, suggesting that this interaction is important for the observed growth arrest phenotype induced by the TAFII70 isoform [6].
  • TAFII70 protein can play a role in lampbrush transcription; alternatively TAFII70 can be considered a component in the subset of TFIID complexes that do not function during oogenesis, but are accumulated in the oocyte for later use during early development [7].
  • In spreads of GV content, anti-hTAFII70 monoclonal antibody (mAb) stained Cajal bodies (CBs) that were either attached to specific sites on the lampbrush chromosomes or free in the nucleoplasm [7].
 

Anatomical context of TAF6

  • The predominant forms found in normal and neoplastic breast epithelial cells are shown to be 72 kDa (TAFII70) and 78 kDa (TAFII80) [6].
  • GADD45a null cells are not subject to TAFII70 inhibition, further supporting the relevance of this interaction [6].
  • The localization of the TATA-binding protein (TBP) associated factor II70 (TAFII70) in the germinal vesicle (GV) of newt oocytes was investigated [7].
 

Analytical, diagnostic and therapeutic context of TAF6

References

  1. The downstream activation sequence of the strict late Herpes Simplex Virus Type 1 U(L)38 promoter interacts with hTAF(II)70, a component of TFIID. Petroski, M.D., Devi-Rao, G.B., Rice, M.K., Wagner, E.K. Virus Genes (2001) [Pubmed]
  2. Core promoter binding by histone-like TAF complexes. Shao, H., Revach, M., Moshonov, S., Tzuman, Y., Gazit, K., Albeck, S., Unger, T., Dikstein, R. Mol. Cell. Biol. (2005) [Pubmed]
  3. The corepressor N-CoR and its variants RIP13a and RIP13Delta1 directly interact with the basal transcription factors TFIIB, TAFII32 and TAFII70. Muscat, G.E., Burke, L.J., Downes, M. Nucleic Acids Res. (1998) [Pubmed]
  4. Expression of TAFII70 RNA and protein during oogenesis and development of the amphibian Pleurodeles waltl. Giani, L., Bucci, S., Ragghianti, M., Mancino, G. Mech. Dev. (2000) [Pubmed]
  5. Specific in vitro interaction between papillomavirus E2 proteins and TBP-associated factors. Carrillo, E., Garrido, E., Gariglio, P. Intervirology (2004) [Pubmed]
  6. TAFII70 isoform-specific growth suppression correlates with its ability to complex with the GADD45a protein. Wang, W., Nahta, R., Huper, G., Marks, J.R. Mol. Cancer Res. (2004) [Pubmed]
  7. TAFII70 protein in Cajal bodies of the amphibian germinal vesicle. Bucci, S., Giani, L., Mancino, G., Pellegrino, M., Ragghianti, M. Genome (2001) [Pubmed]
  8. Cloning and expression of Drosophila TAFII60 and human TAFII70 reveal conserved interactions with other subunits of TFIID. Weinzierl, R.O., Ruppert, S., Dynlacht, B.D., Tanese, N., Tjian, R. EMBO J. (1993) [Pubmed]
 
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