The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

TEAD4  -  TEA domain family member 4

Homo sapiens

Synonyms: EFTR-2, RTEF-1, RTEF1, TCF13L1, TEAD-4, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of TEAD4

  • Surface and intracardiac ECGs revealed prolongation of the PR, QRS, and AH intervals and the appearance of progressive atrial arrhythmias in RTEF-1 mice [1].
  • Acute toxicity was modest and more frequent among those receiving RTEF (P = .08) [2].
 

High impact information on TEAD4

 

Biological context of TEAD4

 

Anatomical context of TEAD4

 

Other interactions of TEAD4

  • This differential interaction also extended to the interaction of TEF-1 and RTEF-1 with TAZ in vivo, as assayed by a modified mammalian two-hybrid experiment [6].
  • Several of these genes, including IL-8, ET-1, ID1, HPTPeta and TEAD4 are reported to be involved in angiogenesis [7].
 

Analytical, diagnostic and therapeutic context of TEAD4

  • An anti-TEFR1 polyclonal antibody supershifted the muscle-specific M-CAT.A1 factor complex in gel mobility shift assays, suggesting that TEFR1 is a major component of this complex [3].
  • Disease free survival rates at five and ten years constituted: PS IA, 78.6% for both; PS IIA, 74.8% and 73.1% (P = .6); RTEF, 76.7% for both; RTIF, 73.3% and 66.7% (P = .7) [2].

References

  1. Transcription enhancer factor-1-related factor-transgenic mice develop cardiac conduction defects associated with altered connexin phosphorylation. Chen, H.H., Baty, C.J., Maeda, T., Brooks, S., Baker, L.C., Ueyama, T., Gursoy, E., Saba, S., Salama, G., London, B., Stewart, A.F. Circulation (2004) [Pubmed]
  2. Pathologic stages IA and IIA Hodgkin's disease: results of treatment with radiotherapy alone (1968-1980). Cornbleet, M.A., Vitolo, U., Ultmann, J.E., Golomb, H.M., Oleske, D., Griem, M.L., Ferguson, D.J., Miller, J.B. J. Clin. Oncol. (1985) [Pubmed]
  3. cDNA cloning and characterization of murine transcriptional enhancer factor-1-related protein 1, a transcription factor that binds to the M-CAT motif. Yockey, C.E., Smith, G., Izumo, S., Shimizu, N. J. Biol. Chem. (1996) [Pubmed]
  4. Regulation of the S100B gene by alpha 1-adrenergic stimulation in cardiac myocytes. Tsoporis, J.N., Marks, A., Van Eldik, L.J., O'Hanlon, D., Parker, T.G. Am. J. Physiol. Heart Circ. Physiol. (2003) [Pubmed]
  5. Cloning of human RTEF-1, a transcriptional enhancer factor-1-related gene preferentially expressed in skeletal muscle: evidence for an ancient multigene family. Stewart, A.F., Richard, C.W., Suzow, J., Stephan, D., Weremowicz, S., Morton, C.C., Adra, C.N. Genomics (1996) [Pubmed]
  6. The transcriptional co-activator TAZ interacts differentially with transcriptional enhancer factor-1 (TEF-1) family members. Mahoney, W.M., Hong, J.H., Yaffe, M.B., Farrance, I.K. Biochem. J. (2005) [Pubmed]
  7. ALK1 signalling analysis identifies angiogenesis related genes and reveals disparity between TGF-beta and constitutively active receptor induced gene expression. Lux, A., Salway, F., Dressman, H.K., Kröner-Lux, G., Hafner, M., Day, P.J., Marchuk, D.A., Garland, J. BMC cardiovascular disorders [electronic resource]. (2006) [Pubmed]
 
WikiGenes - Universities