Gene Review:
TFAM - transcription factor A, mitochondrial
Homo sapiens
Synonyms:
MTTF1, MTTFA, Mitochondrial transcription factor 1, MtTF1, TCF-6, ...
- Mitochondrial transcription factor A and its downstream targets are up-regulated in a rat hepatoma. Dong, X., Ghoshal, K., Majumder, S., Yadav, S.P., Jacob, S.T. J. Biol. Chem. (2002)
- Regulation of mitochondrial D-loops by transcription factor A and single-stranded DNA-binding protein. Takamatsu, C., Umeda, S., Ohsato, T., Ohno, T., Abe, Y., Fukuoh, A., Shinagawa, H., Hamasaki, N., Kang, D. EMBO Rep. (2002)
- Overexpression of mitochondrial transcription factor a ameliorates mitochondrial deficiencies and cardiac failure after myocardial infarction. Ikeuchi, M., Matsusaka, H., Kang, D., Matsushima, S., Ide, T., Kubota, T., Fujiwara, T., Hamasaki, N., Takeshita, A., Sunagawa, K., Tsutsui, H. Circulation (2005)
- Mitochondrial dysfunction in focal segmental glomerulosclerosis of puromycin aminonucleoside nephrosis. Hagiwara, M., Yamagata, K., Capaldi, R.A., Koyama, A. Kidney Int. (2006)
- Low levels of mitochondrial transcription factor A in mitochondrial DNA depletion. Larsson, N.G., Oldfors, A., Holme, E., Clayton, D.A. Biochem. Biophys. Res. Commun. (1994)
- Similarity of human mitochondrial transcription factor 1 to high mobility group proteins. Parisi, M.A., Clayton, D.A. Science (1991)
- Flexible recognition of rapidly evolving promoter sequences by mitochondrial transcription factor 1. Fisher, R.P., Parisi, M.A., Clayton, D.A. Genes Dev. (1989)
- Increased expression of mitochondrial-encoded genes in skeletal muscle of humans with diabetes mellitus. Antonetti, D.A., Reynet, C., Kahn, C.R. J. Clin. Invest. (1995)
- The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells. Gaspari, M., Falkenberg, M., Larsson, N.G., Gustafsson, C.M. EMBO J. (2004)
- Regulation of mitochondrial transcription factor A expression by high glucose. Choi, Y.S., Lee, K.U., Pak, Y.K. Ann. N. Y. Acad. Sci. (2004)
- Increased expression of mitochondrial transcription factor A and nuclear respiratory factor-1 in skeletal muscle from aged human subjects. Lezza, A.M., Pesce, V., Cormio, A., Fracasso, F., Vecchiet, J., Felzani, G., Cantatore, P., Gadaleta, M.N. FEBS Lett. (2001)
- Architectural role of mitochondrial transcription factor A in maintenance of human mitochondrial DNA. Kanki, T., Ohgaki, K., Gaspari, M., Gustafsson, C.M., Fukuoh, A., Sasaki, N., Hamasaki, N., Kang, D. Mol. Cell. Biol. (2004)
- Possible association of mitochondrial transcription factor A (TFAM) genotype with sporadic Alzheimer disease. Günther, C., von Hadeln, K., Müller-Thomsen, T., Alberici, A., Binetti, G., Hock, C., Nitsch, R.M., Stoppe, G., Reiss, J., Gal, A., Finckh, U. Neurosci. Lett. (2004)
- Plasticity of skeletal muscle mitochondria: structure and function. Hoppeler, H., Fluck, M. Medicine and science in sports and exercise. (2003)
- Transient overexpression of mitochondrial transcription factor A (TFAM) is sufficient to stimulate mitochondrial DNA transcription, but not sufficient to increase mtDNA copy number in cultured cells. Maniura-Weber, K., Goffart, S., Garstka, H.L., Montoya, J., Wiesner, R.J. Nucleic Acids Res. (2004)
- Review: Mitochondrial medicine--cardiomyopathy caused by defective oxidative phosphorylation. Fosslien, E. Ann. Clin. Lab. Sci. (2003)
- Import of mitochondrial transcription factor A (TFAM) into rat liver mitochondria stimulates transcription of mitochondrial DNA. Garstka, H.L., Schmitt, W.E., Schultz, J., Sogl, B., Silakowski, B., Pérez-Martos, A., Montoya, J., Wiesner, R.J. Nucleic Acids Res. (2003)
- Down-regulation of mitochondrial transcription factor A during spermatogenesis in humans. Larsson, N.G., Oldfors, A., Garman, J.D., Barsh, G.S., Clayton, D.A. Hum. Mol. Genet. (1997)
- P53 physically interacts with mitochondrial transcription factor A and differentially regulates binding to damaged DNA. Yoshida, Y., Izumi, H., Torigoe, T., Ishiguchi, H., Itoh, H., Kang, D., Kohno, K. Cancer Res. (2003)
- Tubular mitochondrial alterations in neonatal rats subjected to RAS inhibition. Lasaitiene, D., Chen, Y., Mildaziene, V., Nauciene, Z., Sundelin, B., Johansson, B.R., Yano, M., Friberg, P. Am. J. Physiol. Renal Physiol. (2006)
- Mitochondrial nucleoid and transcription factor A. Kanki, T., Nakayama, H., Sasaki, N., Takio, K., Alam, T.I., Hamasaki, N., Kang, D. Ann. N. Y. Acad. Sci. (2004)
- Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells. Pohjoism??ki, J.L., Wanrooij, S., Hyv??rinen, A.K., Goffart, S., Holt, I.J., Spelbrink, J.N., Jacobs, H.T. Nucleic Acids Res. (2006)
- Up-regulation of mitochondrial transcription factor 1 mRNA levels by GH in VSMC. Yoshioka, S., Okimura, Y., Takahashi, Y., Iida, K., Kaji, H., Matsuo, M., Chihara, K. Life Sci. (2004)
- Composition and dynamics of human mitochondrial nucleoids. Garrido, N., Griparic, L., Jokitalo, E., Wartiovaara, J., van der Bliek, A.M., Spelbrink, J.N. Mol. Biol. Cell (2003)
- Regulated mitochondrial DNA replication during oocyte maturation is essential for successful porcine embryonic development. Spikings, E.C., Alderson, J., John, J.C. Biol. Reprod. (2007)
- PDIP38 Associates with Proteins Constituting the Mitochondrial DNA Nucleoid. Cheng, X., Kanki, T., Fukuoh, A., Ohgaki, K., Takeya, R., Aoki, Y., Hamasaki, N., Kang, D. J. Biochem. (2005)
- Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: a potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis. Virbasius, J.V., Scarpulla, R.C. Proc. Natl. Acad. Sci. U.S.A. (1994)
- History of the Tfam gene in primates. D'Errico, I., Dinardo, M.M., Capozzi, O., De Virgilio, C., Gadaleta, G. Gene (2005)
- Familial mitochondrial DNA depletion in liver: haplotype analysis of candidate genes. Spelbrink, J.N., Van Galen, M.J., Zwart, R., Bakker, H.D., Rovio, A., Jacobs, H.T., Van den Bogert, C. Hum. Genet. (1998)
- Purification and characterization of human mitochondrial transcription factor 1. Fisher, R.P., Clayton, D.A. Mol. Cell. Biol. (1988)