Gene Review:
TP53 - tumor protein p53
Homo sapiens
Synonyms:
Antigen NY-CO-13, BCC7, Cellular tumor antigen p53, LFS1, P53, ...
Kelly D. F. Gonzalez,
Yaswen,
Campisi,
Chilakamarti V. Ramana,
Sreerama Shetty,
Praveenkumar Shetty,
Thirunavukkarasu Velusamy,
Yashodhar P. Bhandary,
Steven Idell,
Rashmi S. Shetty,
Stankovic,
Fletcher,
Stewart,
Bignell,
Cronin,
Hubank,
Austen,
Fegan,
Taylor,
Moss,
Alvi,
Weston,
Byrd,
Jonathan F. Lara,
Ann D. Thor,
Lynn G. Dressler,
Gloria Broadwater,
Ira J. Bleiweiss,
Susan Edgerton,
David Cowan,
Lori J. Goldstein,
Silvana Martino,
James N. Ingle,
I. Craig Henderson,
Larry Norton,
Eric P. Winer,
Clifford A. Hudis,
Matthew J. Ellis,
Donald A. Berry,
Daniel F. Hayes,
Bartz,
Oatley,
Guo,
Imakura,
Strulovici,
Zhang,
Friend,
Santini,
Ferrer,
Burchard,
Locco,
Needham,
Gordon,
Chung,
Smith,
Warrener,
Carleton,
Linsley,
Kunapuli,
Martin,
Jackson,
Palmieri,
Berns,
Devilee,
Inganäs,
van Staveren,
Look,
Meijer-van Gelder,
Claassen,
van Putten,
Cornelisse,
Foekens,
Henzen-Logmans,
Bakker,
Klijn,
Vossen,
Portengen,
- Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas. Kurose, K., Gilley, K., Matsumoto, S., Watson, P.H., Zhou, X.P., Eng, C. Nat. Genet. (2002)
- Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster. Dews, M., Homayouni, A., Yu, D., Murphy, D., Sevignani, C., Wentzel, E., Furth, E.E., Lee, W.M., Enders, G.H., Mendell, J.T., Thomas-Tikhonenko, A. Nat. Genet. (2006)
- Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Reilly, K.M., Loisel, D.A., Bronson, R.T., McLaughlin, M.E., Jacks, T. Nat. Genet. (2000)
- The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. Uziel, T., Zindy, F., Xie, S., Lee, Y., Forget, A., Magdaleno, S., Rehg, J.E., Calabrese, C., Solecki, D., Eberhart, C.G., Sherr, S.E., Plimmer, S., Clifford, S.C., Hatten, M.E., McKinnon, P.J., Gilbertson, R.J., Curran, T., Sherr, C.J., Roussel, M.F. Genes Dev. (2005)
- Hypoxia induces p53-dependent transactivation and Fas/CD95-dependent apoptosis. Liu, T., Laurell, C., Selivanova, G., Lundeberg, J., Nilsson, P., Wiman, K.G. Cell Death Differ. (2007)
- Negative regulation of chemokine receptor CXCR4 by tumor suppressor p53 in breast cancer cells: implications of p53 mutation or isoform expression on breast cancer cell invasion. Mehta, S.A., Christopherson, K.W., Bhat-Nakshatri, P., Goulet, R.J., Broxmeyer, H.E., Kopelovich, L., Nakshatri, H. Oncogene (2007)
- Estrogen receptor alpha inhibits p53-mediated transcriptional repression: implications for the regulation of apoptosis. Sayeed, A., Konduri, S.D., Liu, W., Bansal, S., Li, F., Das, G.M. Cancer Res. (2007)
- p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death. Krejci, O., Wunderlich, M., Geiger, H., Chou, F.S., Schleimer, D., Jansen, M., Andreassen, P.R., Mulloy, J.C. Blood (2008)
- p53 Arg72Pro and MDM2 T309G polymorphisms, histology, and esophageal cancer prognosis. Cescon, D.W., Bradbury, P.A., Asomaning, K., Hopkins, J., Zhai, R., Zhou, W., Wang, Z., Kulke, M., Su, L., Ma, C., Xu, W., Marshall, A.L., Heist, R.S., Wain, J.C., Lynch, T.J., Christiani, D.C., Liu, G. Clin. Cancer Res. (2009)
- Prognostic significance of p53 codon 72 polymorphism differs with race in colorectal adenocarcinoma. Katkoori, V.R., Jia, X., Shanmugam, C., Wan, W., Meleth, S., Bumpers, H., Grizzle, W.E., Manne, U. Clin. Cancer Res. (2009)
- High Frequency of p53/MDM2/p14ARF Pathway Abnormalities in Relapsed Neuroblastoma. Carr-Wilkinson, J., O'Toole, K., Wood, K.M., Challen, C.C., Baker, A.G., Board, J.R., Evans, L., Cole, M., Cheung, N.K., Boos, J., Köhler, G., Leuschner, I., Pearson, A.D., Lunec, J., Tweddle, D.A. Clin. Cancer Res. (2010)
- Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Bell, D.W., Varley, J.M., Szydlo, T.E., Kang, D.H., Wahrer, D.C., Shannon, K.E., Lubratovich, M., Verselis, S.J., Isselbacher, K.J., Fraumeni, J.F., Birch, J.M., Li, F.P., Garber, J.E., Haber, D.A. Science (1999)
- Beyond Li Fraumeni Syndrome: clinical characteristics of families with p53 germline mutations. Gonzalez, K.D., Noltner, K.A., Buzin, C.H., Gu, D., Wen-Fong, C.Y., Nguyen, V.Q., Han, J.H., Lowstuter, K., Longmate, J., Sommer, S.S., Weitzel, J.N. J. Clin. Oncol. (2009)
- A cancer family syndrome in twenty-four kindreds. Li, F.P., Fraumeni JF, J.r., Mulvihill, J.J., Blattner, W.A., Dreyfus, M.G., Tucker, M.A., Miller, R.W. Cancer. Res. (1988)
- P53 germline mutations in childhood cancers and cancer risk for carrier individuals. Chompret, A., Brugières, L., Ronsin, M., Gardes, M., Dessarps-Freichey, F., Abel, A., Hua, D., Ligot, L., Dondon, M.G., Bressac-de Paillerets, B., Frébourg, T., Lemerle, J., Bonaïti-Pellié, C., Feunteun, J. Br. J. Cancer. (2000)
- Sensitivity and predictive value of criteria for p53 germline mutation screening. Chompret, A., Abel, A., Stoppa-Lyonnet, D., Brugiéres, L., Pagés, S., Feunteun, J., Bonaïti-Pellié, C. J. Med. Genet. (2001)
- High frequency of de novo mutations in Li-Fraumeni syndrome. Gonzalez, K.D., Buzin, C.H., Noltner, K.A., Gu, D., Li, W., Malkin, D., Sommer, S.S. J. Med. Genet. (2009)
- Human papillomavirus type 16 and TP53 mutation in oral cancer: matched analysis of the IARC multicenter study. Dai, M., Clifford, G.M., le Calvez, F., Castellsagué, X., Snijders, P.J., Pawlita, M., Herrero, R., Hainaut, P., Franceschi, S. Cancer Res. (2004)
- Tumor suppressor gene TP53 is genetically associated with schizophrenia in the Chinese population. Yang, Y., Xiao, Z., Chen, W., Sang, H., Guan, Y., Peng, Y., Zhang, D., Gu, Z., Qian, M., He, G., Qin, W., Li, D., Gu, N., He, L. Neurosci. Lett. (2004)
- The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription. Steffan, J.S., Kazantsev, A., Spasic-Boskovic, O., Greenwald, M., Zhu, Y.Z., Gohler, H., Wanker, E.E., Bates, G.P., Housman, D.E., Thompson, L.M. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Synergistic and opposing regulation of the stress-responsive gene IEX-1 by p53, c-Myc, and multiple NF-kappaB/rel complexes. Huang, Y.H., Wu, J.Y., Zhang, Y., Wu, M.X. Oncogene (2002)
- Tauroursodeoxycholic acid modulates p53-mediated apoptosis in Alzheimer's disease mutant neuroblastoma cells. Ramalho, R.M., Borralho, P.M., Castro, R.E., Solá, S., Steer, C.J., Rodrigues, C.M. J. Neurochem. (2006)
- Oncogene-induced senescence pathways weave an intricate tapestry. Yaswen, P., Campisi, J. Cell (2007)
- Telomeres, p21 and the cancer-aging hypothesis. Bell, J.F., Sharpless, N.E. Nat. Genet. (2007)
- NEDD4-1 Is a Proto-Oncogenic Ubiquitin Ligase for PTEN. Wang, X., Trotman, L.C., Koppie, T., Alimonti, A., Chen, Z., Gao, Z., Wang, J., Erdjument-Bromage, H., Tempst, P., Cordon-Cardo, C., Pandolfi, P.P., Jiang, X. Cell (2007)
- PRAK Is Essential for ras-Induced Senescence and Tumor Suppression. Sun, P., Yoshizuka, N., New, L., Moser, B.A., Li, Y., Liao, R., Xie, C., Chen, J., Deng, Q., Yamout, M., Dong, M.Q., Frangou, C.G., Yates, J.R., Wright, P.E., Han, J. Cell (2007)
- A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Zhang, D., Zaugg, K., Mak, T.W., Elledge, S.J. Cell (2006)
- Determination of TP53 mutation is more relevant than microsatellite instability status for the prediction of disease-free survival in adjuvant-treated stage III colon cancer patients. Westra, J.L., Schaapveld, M., Hollema, H., de Boer, J.P., Kraak, M.M., de Jong, D., ter Elst, A., Mulder, N.H., Buys, C.H., Hofstra, R.M., Plukker, J.T. J. Clin. Oncol. (2005)
- Complete sequencing of TP53 predicts poor response to systemic therapy of advanced breast cancer. Berns, E.M., Foekens, J.A., Vossen, R., Look, M.P., Devilee, P., Henzen-Logmans, S.C., van Staveren, I.L., van Putten, W.L., Inganäs, M., Meijer-van Gelder, M.E., Cornelisse, C., Claassen, C.J., Portengen, H., Bakker, B., Klijn, J.G. Cancer Res. (2000)
- The p53 tumor suppressor network is a key responder to microenvironmental components of chronic inflammatory stress. Staib, F., Robles, A.I., Varticovski, L., Wang, X.W., Zeeberg, B.R., Sirotin, M., Zhurkin, V.B., Hofseth, L.J., Hussain, S.P., Weinstein, J.N., Galle, P.R., Harris, C.C. Cancer Res. (2005)
- Methylation of CpG dinucleotides and/or CCWGG motifs at the promoter of TP53 correlates with decreased gene expression in a subset of acute lymphoblastic leukemia patients. Agirre, X., Vizmanos, J.L., Calasanz, M.J., García-Delgado, M., Larráyoz, M.J., Novo, F.J. Oncogene (2003)
- Altered levels and regulation of stathmin in paclitaxel-resistant ovarian cancer cells. Balachandran, R., Welsh, M.J., Day, B.W. Oncogene (2003)
- Mutations truncating the EP300 acetylase in human cancers. Gayther, S.A., Batley, S.J., Linger, L., Bannister, A., Thorpe, K., Chin, S.F., Daigo, Y., Russell, P., Wilson, A., Sowter, H.M., Delhanty, J.D., Ponder, B.A., Kouzarides, T., Caldas, C. Nat. Genet. (2000)
- Evolution of neoplastic cell lineages in Barrett oesophagus. Barrett, M.T., Sanchez, C.A., Prevo, L.J., Wong, D.J., Galipeau, P.C., Paulson, T.G., Rabinovitch, P.S., Reid, B.J. Nat. Genet. (1999)
- Overcoming cellular senescence in human cancer pathogenesis. Yeager, T.R., DeVries, S., Jarrard, D.F., Kao, C., Nakada, S.Y., Moon, T.D., Bruskewitz, R., Stadler, W.M., Meisner, L.F., Gilchrist, K.W., Newton, M.A., Waldman, F.M., Reznikoff, C.A. Genes Dev. (1998)
- Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines. Liu, Y., Bodmer, W.F. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Microarray analysis reveals that TP53- and ATM-mutant B-CLLs share a defect in activating proapoptotic responses after DNA damage but are distinguished by major differences in activating prosurvival responses. Stankovic, T., Hubank, M., Cronin, D., Stewart, G.S., Fletcher, D., Bignell, C.R., Alvi, A.J., Austen, B., Weston, V.J., Fegan, C., Byrd, P.J., Moss, P.A., Taylor, A.M. Blood (2004)
- Small Interfering RNA Screens Reveal Enhanced Cisplatin Cytotoxicity in Tumor Cells Having both BRCA Network and TP53 Disruptions. Bartz, S.R., Zhang, Z., Burchard, J., Imakura, M., Martin, M., Palmieri, A., Needham, R., Guo, J., Gordon, M., Chung, N., Warrener, P., Jackson, A.L., Carleton, M., Oatley, M., Locco, L., Santini, F., Smith, T., Kunapuli, P., Ferrer, M., Strulovici, B., Friend, S.H., Linsley, P.S. Mol. Cell. Biol. (2006)
- Activation of nuclear factor kappaB in radioresistance of TP53-inactive human keratinocytes. Chen, X., Shen, B., Xia, L., Khaletzkiy, A., Chu, D., Wong, J.Y., Li, J.J. Cancer Res. (2002)
- TP53 and KRAS2 mutations in plasma DNA of healthy subjects and subsequent cancer occurrence: a prospective study. Gormally, E., Vineis, P., Matullo, G., Veglia, F., Caboux, E., Le Roux, E., Peluso, M., Garte, S., Guarrera, S., Munnia, A., Airoldi, L., Autrup, H., Malaveille, C., Dunning, A., Overvad, K., Tjønneland, A., Lund, E., Clavel-Chapelon, F., Boeing, H., Trichopoulou, A., Palli, D., Krogh, V., Tumino, R., Panico, S., Bueno-de-Mesquita, H.B., Peeters, P.H., Pera, G., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quirós, J.R., Hallmans, G., Day, N.E., Key, T.J., Saracci, R., Kaaks, R., Riboli, E., Hainaut, P. Cancer Res. (2006)
- The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Dumont, P., Leu, J.I., Della Pietra, A.C., George, D.L., Murphy, M. Nat. Genet. (2003)
- A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival. Alvi, A.J., Austen, B., Weston, V.J., Fegan, C., MacCallum, D., Gianella-Borradori, A., Lane, D.P., Hubank, M., Powell, J.E., Wei, W., Taylor, A.M., Moss, P.A., Stankovic, T. Blood (2005)
- Methylation-acetylation interplay activates p53 in response to DNA damage. Ivanov, G.S., Ivanova, T., Kurash, J., Ivanov, A., Chuikov, S., Gizatullin, F., Herrera-Medina, E.M., Rauscher, F., Reinberg, D., Barlev, N.A. Mol. Cell. Biol. (2007)
- PRIMA-1(MET) induces nucleolar accumulation of mutant p53 and PML nuclear body-associated proteins. Rökaeus, N., Klein, G., Wiman, K.G., Szekely, L., Mattsson, K. Oncogene (2007)
- Regulation of H-ras splice variant expression by cross talk between the p53 and nonsense-mediated mRNA decay pathways. Barbier, J., Dutertre, M., Bittencourt, D., Sanchez, G., Gratadou, L., de la Grange, P., Auboeuf, D. Mol. Cell. Biol. (2007)
- Inhibition of p53-murine double minute 2 interaction by nutlin-3A stabilizes p53 and induces cell cycle arrest and apoptosis in Hodgkin lymphoma. Drakos, E., Thomaides, A., Medeiros, L.J., Li, J., Leventaki, V., Konopleva, M., Andreeff, M., Rassidakis, G.Z. Clin. Cancer Res. (2007)
- p53 mediates senescence-like arrest induced by chronic replicational stress. Marusyk, A., Wheeler, L.J., Mathews, C.K., DeGregori, J. Mol. Cell. Biol. (2007)
- p53 is localized to a sub-nucleolar compartment after proteasomal inhibition in an energy-dependent manner. Karni-Schmidt, O., Zupnick, A., Castillo, M., Ahmed, A., Matos, T., Bouvet, P., Cordon-Cardo, C., Prives, C. J. Cell. Sci. (2008)
- Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5. Carter, B.Z., Mak, D.H., Schober, W.D., Dietrich, M.F., Pinilla, C., Vassilev, L.T., Reed, J.C., Andreeff, M. Blood (2008)
- p53 Expression in node-positive breast cancer patients: results from the Cancer and Leukemia Group B 9344 Trial (159905). Lara, J.F., Thor, A.D., Dressler, L.G., Broadwater, G., Bleiweiss, I.J., Edgerton, S., Cowan, D., Goldstein, L.J., Martino, S., Ingle, J.N., Henderson, I.C., Norton, L., Winer, E.P., Hudis, C.A., Ellis, M.J., Berry, D.A., Hayes, D.F. Clin. Cancer Res. (2011)
- Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis. Bernal, J.A., Luna, R., Espina, A., Lázaro, I., Ramos-Morales, F., Romero, F., Arias, C., Silva, A., Tortolero, M., Pintor-Toro, J.A. Nat. Genet. (2002)
- Role for c-Abl tyrosine kinase in growth arrest response to DNA damage. Yuan, Z.M., Huang, Y., Whang, Y., Sawyers, C., Weichselbaum, R., Kharbanda, S., Kufe, D. Nature (1996)
- Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Li, M., Chen, D., Shiloh, A., Luo, J., Nikolaev, A.Y., Qin, J., Gu, W. Nature (2002)
- Repression of p53-mediated transcription by MDM2: a dual mechanism. Thut, C.J., Goodrich, J.A., Tjian, R. Genes Dev. (1997)
- Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Chehab, N.H., Malikzay, A., Appel, M., Halazonetis, T.D. Genes Dev. (2000)
- HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. Sasaki, T., Gan, E.C., Wakeham, A., Kornbluth, S., Mak, T.W., Okada, H. Genes Dev. (2007)
- BLIMP1 regulates cell growth through repression of p53 transcription. Yan, J., Jiang, J., Lim, C.A., Wu, Q., Ng, H.H., Chin, K.C. Proc. Natl. Acad. Sci. U.S.A. (2007)
- MDM2 binding induces a conformational change in p53 that is opposed by heat-shock protein 90 and precedes p53 proteasomal degradation. Sasaki, M., Nie, L., Maki, C.G. J. Biol. Chem. (2007)
- Regulation of plasminogen activator inhibitor-1 expression by tumor suppressor protein p53. Shetty, S., Shetty, P., Idell, S., Velusamy, T., Bhandary, Y.P., Shetty, R.S. J. Biol. Chem. (2008)
- Modulation of the oligomerization state of p53 by differential binding of proteins of the S100 family to p53 monomers and tetramers. van Dieck, J., Fernandez-Fernandez, M.R., Veprintsev, D.B., Fersht, A.R. J. Biol. Chem. (2009)
- Insight into the structural basis of pro- and antiapoptotic p53 modulation by ASPP proteins. Ahn, J., Byeon, I.J., Byeon, C.H., Gronenborn, A.M. J. Biol. Chem. (2009)
- The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Shieh, S.Y., Ahn, J., Tamai, K., Taya, Y., Prives, C. Genes Dev. (2000)
- PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints. Lu, X., Nannenga, B., Donehower, L.A. Genes Dev. (2005)
- Involvement of PIAS1 in the sumoylation of tumor suppressor p53. Kahyo, T., Nishida, T., Yasuda, H. Mol. Cell (2001)
- p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner. Ko, L.J., Shieh, S.Y., Chen, X., Jayaraman, L., Tamai, K., Taya, Y., Prives, C., Pan, Z.Q. Mol. Cell. Biol. (1997)
- A new p21waf1/cip1 isoform is an early event of cell response to oxidative stress. Esposito, F., Cuccovillo, F., Russo, L., Casella, F., Russo, T., Cimino, F. Cell Death Differ. (1998)
- Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death. Lee, J.H., Kim, H.S., Lee, S.J., Kim, K.T. J. Cell. Sci. (2007)
- p53 Modulates the exonuclease activity of Werner syndrome protein. Brosh, R.M., Karmakar, P., Sommers, J.A., Yang, Q., Wang, X.W., Spillare, E.A., Harris, C.C., Bohr, V.A. J. Biol. Chem. (2001)
- The calcium-binding protein S100A2 interacts with p53 and modulates its transcriptional activity. Mueller, A., Schäfer, B.W., Ferrari, S., Weibel, M., Makek, M., Höchli, M., Heizmann, C.W. J. Biol. Chem. (2005)
- Accumulation of soluble and nucleolar-associated p53 proteins following cellular stress. Klibanov, S.A., O'Hagan, H.M., Ljungman, M. J. Cell. Sci. (2001)
- Interstitial chromatin alteration causes persistent p53 activation involved in the radiation-induced senescence-like growth arrest. Suzuki, M., Suzuki, K., Kodama, S., Watanabe, M. Biochem. Biophys. Res. Commun. (2006)
- Yin Yang 1 is a negative regulator of p53. Sui, G., Affar, e.l. .B., Shi, Y., Brignone, C., Wall, N.R., Yin, P., Donohoe, M., Luke, M.P., Calvo, D., Grossman, S.R., Shi, Y. Cell (2004)
- Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway. Rouault, J.P., Falette, N., Guéhenneux, F., Guillot, C., Rimokh, R., Wang, Q., Berthet, C., Moyret-Lalle, C., Savatier, P., Pain, B., Shaw, P., Berger, R., Samarut, J., Magaud, J.P., Ozturk, M., Samarut, C., Puisieux, A. Nat. Genet. (1996)
- iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human. Bergamaschi, D., Samuels, Y., O'Neil, N.J., Trigiante, G., Crook, T., Hsieh, J.K., O'Connor, D.J., Zhong, S., Campargue, I., Tomlinson, M.L., Kuwabara, P.E., Lu, X. Nat. Genet. (2003)
- The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Waga, S., Hannon, G.J., Beach, D., Stillman, B. Nature (1994)
- hAda3 regulates p14ARF-induced p53 acetylation and senescence. Sekaric, P., Shamanin, V.A., Luo, J., Androphy, E.J. Oncogene (2007)
- Mutations in the DNA-binding codons of TP53, which are associated with decreased expression of TRAILreceptor-2, predict for poor survival in diffuse large B-cell lymphoma. Young, K.H., Weisenburger, D.D., Dave, B.J., Smith, L., Sanger, W., Iqbal, J., Campo, E., Delabie, J., Gascoyne, R.D., Ott, G., Rimsza, L., Müller-Hermelink, H.K., Jaffe, E.S., Rosenwald, A., Staudt, L.M., Chan, W.C., Greiner, T.C. Blood (2007)
- Activated Notch1 interacts with p53 to inhibit its phosphorylation and transactivation. Kim, S.B., Chae, G.W., Lee, J., Park, J., Tak, H., Chung, J.H., Park, T.G., Ahn, J.K., Joe, C.O. Cell Death Differ. (2007)
- The MDM2 ubiquitination signal in the DNA-binding domain of p53 forms a docking site for calcium calmodulin kinase superfamily members. Craig, A.L., Chrystal, J.A., Fraser, J.A., Sphyris, N., Lin, Y., Harrison, B.J., Scott, M.T., Dornreiter, I., Hupp, T.R. Mol. Cell. Biol. (2007)
- Activation of p53 function by human transcriptional coactivator PC4: role of protein-protein interaction, DNA bending, and posttranslational modifications. Batta, K., Kundu, T.K. Mol. Cell. Biol. (2007)
- DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage. Taira, N., Nihira, K., Yamaguchi, T., Miki, Y., Yoshida, K. Mol. Cell (2007)
- Stabilization and activation of p53 are regulated independently by different phosphorylation events. Chernov, M.V., Ramana, C.V., Adler, V.V., Stark, G.R. Proc. Natl. Acad. Sci. U. S. A. (1998)
- An acetylation switch in p53 mediates holo-TFIID recruitment. Li, A.G., Piluso, L.G., Cai, X., Gadd, B.J., Ladurner, A.G., Liu, X. Mol. Cell (2007)
- P53 mRNA controls p53 activity by managing Mdm2 functions. Candeias, M.M., Malbert-Colas, L., Powell, D.J., Daskalogianni, C., Maslon, M.M., Naski, N., Bourougaa, K., Calvo, F., Fåhraeus, R. Nat. Cell Biol. (2008)
- A regulatory loop composed of RAP80-HDM2-p53 provides RAP80-enhanced p53 degradation by HDM2 in response to DNA damage. Yan, J., Menendez, D., Yang, X.P., Resnick, M.A., Jetten, A.M. J. Biol. Chem. (2009)
- A novel human p53 isoform is an essential element of the ATR-intra-S phase checkpoint. Rohaly, G., Chemnitz, J., Dehde, S., Nunez, A.M., Heukeshoven, J., Deppert, W., Dornreiter, I. Cell (2005)
- Use of human tissue to assess the oncogenic activity of melanoma-associated mutations. Chudnovsky, Y., Adams, A.E., Robbins, P.B., Lin, Q., Khavari, P.A. Nat. Genet. (2005)
- p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Dulić, V., Kaufmann, W.K., Wilson, S.J., Tlsty, T.D., Lees, E., Harper, J.W., Elledge, S.J., Reed, S.I. Cell (1994)
- CDK8 is a stimulus-specific positive coregulator of p53 target genes. Donner, A.J., Szostek, S., Hoover, J.M., Espinosa, J.M. Mol. Cell (2007)
- Flt3 Y591 duplication and Bcl-2 overexpression are detected in acute myeloid leukemia cells with high levels of phosphorylated wild-type p53. Irish, J.M., Anensen, N., Hovland, R., Skavland, J., Børresen-Dale, A.L., Bruserud, O., Nolan, G.P., Gjertsen, B.T. Blood (2007)
- Targeted repression of bone morphogenetic protein 7, a novel target of the p53 family, triggers proliferative defect in p53-deficient breast cancer cells. Yan, W., Chen, X. Cancer Res. (2007)
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