Gene Review:
TRAF1 - TNF receptor-associated factor 1
Homo sapiens
Synonyms:
EBI6, Epstein-Barr virus-induced protein 6, MGC:10353
- The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Mosialos, G., Birkenbach, M., Yalamanchili, R., VanArsdale, T., Ware, C., Kieff, E. Cell (1995)
- Tumor necrosis factor receptor-associated factor 1 is overexpressed in Reed-Sternberg cells of Hodgkin's disease and Epstein-Barr virus-transformed lymphoid cells. Dürkop, H., Foss, H.D., Demel, G., Klotzbach, H., Hahn, C., Stein, H. Blood (1999)
- Tumor necrosis factor receptor-associated factor 1 gene overexpression in B-cell chronic lymphocytic leukemia: analysis of NF-kappa B/Rel-regulated inhibitors of apoptosis. Munzert, G., Kirchner, D., Stobbe, H., Bergmann, L., Schmid, R.M., Döhner, H., Heimpel, H. Blood (2002)
- NF-kappaB2 mutation targets TRAF1 to induce lymphomagenesis. Zhang, B., Wang, Z., Li, T., Tsitsikov, E.N., Ding, H.F. Blood (2007)
- Tumor necrosis factor receptor and Fas signaling mechanisms. Wallach, D., Varfolomeev, E.E., Malinin, N.L., Goltsev, Y.V., Kovalenko, A.V., Boldin, M.P. Annu. Rev. Immunol. (1999)
- A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction. Park, Y.C., Ye, H., Hsia, C., Segal, D., Rich, R.L., Liou, H.C., Myszka, D.G., Wu, H. Cell (2000)
- The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Rothe, M., Pan, M.G., Henzel, W.J., Ayres, T.M., Goeddel, D.V. Cell (1995)
- TRAF6 is a signal transducer for interleukin-1. Cao, Z., Xiong, J., Takeuchi, M., Kurama, T., Goeddel, D.V. Nature (1996)
- CD40-mediated regulation of immune responses by TRAF-dependent and TRAF-independent signaling mechanisms. Grammer, A.C., Lipsky, P.E. Adv. Immunol. (2000)
- TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling. Ishida, T.K., Tojo, T., Aoki, T., Kobayashi, N., Ohishi, T., Watanabe, T., Yamamoto, T., Inoue, J. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Molecular characterization of CD40 signaling intermediates. Werneburg, B.G., Zoog, S.J., Dang, T.T., Kehry, M.R., Crute, J.J. J. Biol. Chem. (2001)
- TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis. Leo, E., Deveraux, Q.L., Buchholtz, C., Welsh, K., Matsuzawa, S., Stennicke, H.R., Salvesen, G.S., Reed, J.C. J. Biol. Chem. (2001)
- Organization of the human tumour necrosis factor receptor-associated factor 1 (TRAF1) gene and mapping to chromosome 9q33-34. Siemienski, K., Peters, N., Scheurich, P., Wajant, H. Gene (1997)
- CD30 induction of human immunodeficiency virus gene transcription is mediated by TRAF2. Tsitsikov, E.N., Wright, D.A., Geha, R.S. Proc. Natl. Acad. Sci. U.S.A. (1997)
- TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies. Zapata, J.M., Krajewska, M., Krajewski, S., Kitada, S., Welsh, K., Monks, A., McCloskey, N., Gordon, J., Kipps, T.J., Gascoyne, R.D., Shabaik, A., Reed, J.C. J. Immunol. (2000)
- TRAF1 is a critical regulator of JNK signaling by the TRAF-binding domain of the Epstein-Barr virus-encoded latent infection membrane protein 1 but not CD40. Eliopoulos, A.G., Waites, E.R., Blake, S.M., Davies, C., Murray, P., Young, L.S. J. Virol. (2003)
- Expression of the tumor necrosis factor receptor-associated factors (TRAFs) 1 and 2 is a characteristic feature of Hodgkin and Reed-Sternberg cells. Izban, K.F., Ergin, M., Martinez, R.L., Alkan, S. Mod. Pathol. (2000)
- Caspase-cleaved TRAF1 negatively regulates the antiapoptotic signals of TRAF2 during TNF-induced cell death. Jang, H.D., Chung, Y.M., Baik, J.H., Choi, Y.G., Park, I.S., Jung, Y.K., Lee, S.Y. Biochem. Biophys. Res. Commun. (2001)
- Regulation of phorbol ester-mediated TRAF1 induction in human colon cancer cells through a PKC/RAF/ERK/NF-kappaB-dependent pathway. Wang, X., Wang, Q., Hu, W., Evers, B.M. Oncogene (2004)
- A critical role for TNF receptor-associated factor 1 and Bim down-regulation in CD8 memory T cell survival. Sabbagh, L., Srokowski, C.C., Pulle, G., Snell, L.M., Sedgmen, B.J., Liu, Y., Tsitsikov, E.N., Watts, T.H. Proc. Natl. Acad. Sci. U.S.A. (2006)
- A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40. Sato, T., Irie, S., Reed, J.C. FEBS Lett. (1995)
- The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation. Song, H.Y., Rothe, M., Goeddel, D.V. Proc. Natl. Acad. Sci. U.S.A. (1996)
- CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins. Gedrich, R.W., Gilfillan, M.C., Duckett, C.S., Van Dongen, J.L., Thompson, C.B. J. Biol. Chem. (1996)
- Characterization of the roles of TNF receptor-associated factor 6 in CD40-mediated B lymphocyte effector functions. Jalukar, S.V., Hostager, B.S., Bishop, G.A. J. Immunol. (2000)
- Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas ligand-mediated apoptosis. Irmler, M., Steiner, V., Ruegg, C., Wajant, H., Tschopp, J. FEBS Lett. (2000)
- Tumor necrosis factor receptor-associated factor (TRAF) 1 regulates CD40-induced TRAF2-mediated NF-kappaB activation. Fotin-Mleczek, M., Henkler, F., Hausser, A., Glauner, H., Samel, D., Graness, A., Scheurich, P., Mauri, D., Wajant, H. J. Biol. Chem. (2004)
- CD40-mediated signaling in monocytic cells: up-regulation of tumor necrosis factor receptor-associated factor mRNAs and activation of mitogen-activated protein kinase signaling pathways. Pearson, L.L., Castle, B.E., Kehry, M.R. Int. Immunol. (2001)
- Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase. Kim, H.H., Lee, D.E., Shin, J.N., Lee, Y.S., Jeon, Y.M., Chung, C.H., Ni, J., Kwon, B.S., Lee, Z.H. FEBS Lett. (1999)
- Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein. Kaye, K.M., Devergne, O., Harada, J.N., Izumi, K.M., Yalamanchili, R., Kieff, E., Mosialos, G. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Differential requirements for tumor necrosis factor receptor-associated factor family proteins in CD40-mediated induction of NF-kappaB and Jun N-terminal kinase activation. Leo, E., Welsh, K., Matsuzawa, S., Zapata, J.M., Kitada, S., Mitchell, R.S., Ely, K.R., Reed, J.C. J. Biol. Chem. (1999)
- The human tumor necrosis factor (TNF) receptor-associated factor 1 gene (TRAF1) is up-regulated by cytokines of the TNF ligand family and modulates TNF-induced activation of NF-kappaB and c-Jun N-terminal kinase. Schwenzer, R., Siemienski, K., Liptay, S., Schubert, G., Peters, N., Scheurich, P., Schmid, R.M., Wajant, H. J. Biol. Chem. (1999)
- Cooperation between TNF Receptor-Associated Factors 1 and 2 in CD40 Signaling. Xie, P., Hostager, B.S., Munroe, M.E., Moore, C.R., Bishop, G.A. J. Immunol. (2006)