Gene Review:
TRAF5 - TNF receptor-associated factor 5
Homo sapiens
Synonyms:
MGC:39780, RING finger protein 84, RNF84
Nakano,
Sakon,
Koseki,
Takemori,
Tada,
Matsumoto,
Munechika,
Sakai,
Shirasawa,
Akiba,
Kobata,
Santee,
Ware,
Rennert,
Taniguchi,
Yagita,
Okumura,
Nakano,
Shindo,
Yamada,
Yoshida,
Santee,
Ware,
Jenkins,
Gilbert,
Yagita,
Copeland,
Okumura,
Hsu,
Solovyev,
Colombero,
Elliott,
Kelley,
Boyle,
Shirakata,
Imadome,
Okazaki,
Hirai,
- Activation of TRAF5 and TRAF6 signal cascades negatively regulates the latent replication origin of Epstein-Barr virus through p38 mitogen-activated protein kinase. Shirakata, M., Imadome, K.I., Okazaki, K., Hirai, K. J. Virol. (2001)
- Ethanol potentiates HIV-1 gp120-induced apoptosis in human neurons via both the death receptor and NMDA receptor pathways. Chen, W., Tang, Z., Fortina, P., Patel, P., Addya, S., Surrey, S., Acheampong, E.A., Mukhtar, M., Pomerantz, R.J. Virology (2005)
- Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif. Saha, S.K., Pietras, E.M., He, J.Q., Kang, J.R., Liu, S.Y., Oganesyan, G., Shahangian, A., Zarnegar, B., Shiba, T.L., Wang, Y., Cheng, G. EMBO J. (2006)
- Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation. Nakano, H., Sakon, S., Koseki, H., Takemori, T., Tada, K., Matsumoto, M., Munechika, E., Sakai, T., Shirasawa, T., Akiba, H., Kobata, T., Santee, S.M., Ware, C.F., Rennert, P.D., Taniguchi, M., Yagita, H., Okumura, K. Proc. Natl. Acad. Sci. U.S.A. (1999)
- TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling. Ishida, T.K., Tojo, T., Aoki, T., Kobayashi, N., Ohishi, T., Watanabe, T., Yamamoto, T., Inoue, J. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif. Darnay, B.G., Ni, J., Moore, P.A., Aggarwal, B.B. J. Biol. Chem. (1999)
- Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5). Mizushima, S., Fujita, M., Ishida, T., Azuma, S., Kato, K., Hirai, M., Otsuka, M., Yamamoto, T., Inoue, J. Gene (1998)
- Human TNF receptor-associated factor 5 (TRAF5): cDNA cloning, expression and assignment of the TRAF5 gene to chromosome 1q32. Nakano, H., Shindo, M., Yamada, K., Yoshida, M.C., Santee, S.M., Ware, C.F., Jenkins, N.A., Gilbert, D.J., Yagita, H., Copeland, N.C., Okumura, K. Genomics (1997)
- Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase. Kim, H.H., Lee, D.E., Shin, J.N., Lee, Y.S., Jeon, Y.M., Chung, C.H., Ni, J., Kwon, B.S., Lee, Z.H. FEBS Lett. (1999)
- Expression of the tumor necrosis factor receptor-associated factors (TRAFs) 1 and 2 is a characteristic feature of Hodgkin and Reed-Sternberg cells. Izban, K.F., Ergin, M., Martinez, R.L., Alkan, S. Mod. Pathol. (2000)
- Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation. Aizawa, S., Nakano, H., Ishida, T., Horie, R., Nagai, M., Ito, K., Yagita, H., Okumura, K., Inoue, J., Watanabe, T. J. Biol. Chem. (1997)
- Tumor necrosis factor receptor (TNFR)-associated factor 5 is a critical intermediate of costimulatory signaling pathways triggered by glucocorticoid-induced TNFR in T cells. Esparza, E.M., Lindsten, T., Stockhausen, J.M., Arch, R.H. J. Biol. Chem. (2006)
- Molecular study on chicken tumor necrosis factor receptor-II and tumor necrosis factor receptor-associated factor-5. Abdalla, S.A., Horiuchi, H., Furusawa, S., Matsuda, H. Vet. Immunol. Immunopathol. (2004)
- CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization. Pullen, S.S., Miller, H.G., Everdeen, D.S., Dang, T.T., Crute, J.J., Kehry, M.R. Biochemistry (1998)
- Physiological and molecular effects of Apo2L/TRAIL and cisplatin in ovarian carcinoma cell lines. Siervo-Sassi, R.R., Marrangoni, A.M., Feng, X., Naoumova, N., Winans, M., Edwards, R.P., Lokshin, A. Cancer Lett. (2003)
- Cytoplasmic aggregation of TRAF2 and TRAF5 proteins in the Hodgkin-Reed-Sternberg cells. Horie, R., Watanabe, T., Ito, K., Morisita, Y., Watanabe, M., Ishida, T., Higashihara, M., Kadin, M., Watanabe, T. Am. J. Pathol. (2002)
- The role of apoptosis signal-regulating kinase 1 in lymphotoxin-beta receptor-mediated cell death. Chen, M.C., Hwang, M.J., Chou, Y.C., Chen, W.H., Cheng, G., Nakano, H., Luh, T.Y., Mai, S.C., Hsieh, S.L. J. Biol. Chem. (2003)
- The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor. Wong, B.R., Josien, R., Lee, S.Y., Vologodskaia, M., Steinman, R.M., Choi, Y. J. Biol. Chem. (1998)
- Frequent expression of the variant CD30 in human malignant myeloid and lymphoid neoplasms. Horie, R., Gattei, V., Ito, K., Imajo-Ohmi, S., Tange, T., Miyauchi, J., Pinto, A., Degan, M., De Iuliis, A., Tassan Mazzocco, F., Rossi, F.M., Higashihara, M., Watanabe, T. Am. J. Pathol. (1999)
- ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5. Hsu, H., Solovyev, I., Colombero, A., Elliott, R., Kelley, M., Boyle, W.J. J. Biol. Chem. (1997)
- CD40-mediated signaling in monocytic cells: up-regulation of tumor necrosis factor receptor-associated factor mRNAs and activation of mitogen-activated protein kinase signaling pathways. Pearson, L.L., Castle, B.E., Kehry, M.R. Int. Immunol. (2001)