Gene Review:
TRHR - thyrotropin-releasing hormone receptor
Homo sapiens
Synonyms:
TRH-R, Thyroliberin receptor, Thyrotropin-releasing hormone receptor
- Real time visualization of agonist-mediated redistribution and internalization of a green fluorescent protein-tagged form of the thyrotropin-releasing hormone receptor. Drmota, T., Gould, G.W., Milligan, G. J. Biol. Chem. (1998)
- A novel transcript for the thyrotropin-releasing hormone receptor in human pituitary and pituitary tumors. Yamada, M., Hashimoto, K., Satoh, T., Shibusawa, N., Kohga, H., Ozawa, Y., Yamada, S., Mori, M. J. Clin. Endocrinol. Metab. (1997)
- Gene expression study of thyrotropin releasing hormone (TRH) receptor using RT-PCR: relationship to clinical and immunohistochemical phenotypes in a series of human pituitary adenomas. Igarashi-Migitaka, J., Yamada, S., Hara, M., Sano, T., Ozawa, Y., Ohtani-Kaneko, R., Hirata, K. Endocr. J. (2003)
- Somatotroph to thyrotroph cell transdifferentiation during experimental hypothyroidism - a light and electron-microscopy study. Radian, S., Coculescu, M., Morris, J.F. J. Cell. Mol. Med. (2003)
- Thyrotropin-releasing hormone receptor (TRHR) gene is associated with essential hypertension. García, S.I., Porto, P.I., Dieuzeide, G., Landa, M.S., Kirszner, T., Plotquin, Y., Gonzalez, C., Pirola, C.J. Hypertension (2001)
- Visualization of the thyrotropin-releasing hormone receptor and its ligand during endocytosis and recycling. Ashworth, R., Yu, R., Nelson, E.J., Dermer, S., Gershengorn, M.C., Hinkle, P.M. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Casein kinase II sites in the intracellular C-terminal domain of the thyrotropin-releasing hormone receptor and chimeric gonadotropin-releasing hormone receptors contribute to beta-arrestin-dependent internalization. Hanyaloglu, A.C., Vrecl, M., Kroeger, K.M., Miles, L.E., Qian, H., Thomas, W.G., Eidne, K.A. J. Biol. Chem. (2001)
- A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor. Cook, J.V., McGregor, A., Lee, T., Milligan, G., Eidne, K.A. Endocrinology (1996)
- Prolonged agonist stimulation does not alter the protein composition of membrane domains in spite of dramatic changes induced in a specific signaling cascade. Matousek, P., Novotny, J., Rudajev, V., Svoboda, P. Cell Biochem. Biophys. (2005)
- Resolution of G(s)alpha and G(q)alpha/G(11)alpha proteins in membrane domains by two-dimensional electrophoresis: the effect of long-term agonist stimulation. Matousek, P., Novotný, J., Svoboda, P. Physiological research / Academia Scientiarum Bohemoslovaca. (2004)
- Assignment of the gene encoding the human thyrotropin-releasing hormone receptor to 8q23 by fluorescence in situ hybridization. Morrison, N., Duthie, S.M., Boyd, E., Eidne, K.A., Connor, J.M. Hum. Genet. (1994)
- Molecular cloning of a functional human thyrotropin-releasing hormone receptor. Matre, V., Karlsen, H.E., Wright, M.S., Lundell, I., Fjeldheim, A.K., Gabrielsen, O.S., Larhammar, D., Gautvik, K.M. Biochem. Biophys. Res. Commun. (1993)
- The human neuroendocrine thyrotropin-releasing hormone receptor promoter is activated by the haematopoietic transcription factor c-Myb. Matre, V., Høvring, P.I., Fjeldheim, A.K., Helgeland, L., Orvain, C., Andersson, K.B., Gautvik, K.M., Gabrielsen, O.S. Biochem. J. (2003)
- The thyrotropin-releasing hormone-receptor complex and G11alpha are both internalised into clathrin-coated vesicles. Petrou, C., Tashjian, A.H. Cell. Signal. (1998)
- Production and characterization of an antiserum which recognizes the native receptor for thyrotropin-releasing hormone. Chen, F., Selinger, Z., Marks, P., Belinsky, G., Tashjian, A.H. Biochem. Biophys. Res. Commun. (2001)
- Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8. Yamada, M., Monden, T., Konaka, S., Mori, M. Somat. Cell Mol. Genet. (1993)
- Effect of cell type on the subcellular localization of the thyrotropin-releasing hormone receptor. Yu, R., Hinkle, P.M. Mol. Pharmacol. (1997)
- Thyrotropin-releasing hormone receptor processing: role of ubiquitination and proteasomal degradation. Cook, L.B., Zhu, C.C., Hinkle, P.M. Mol. Endocrinol. (2003)
- Thyrotropin-releasing hormone (TRH) receptor number determines the size of the TRH-responsive phosphoinositide pool. Demonstration using controlled expression of TRH receptors by adenovirus mediated gene transfer. Gershengorn, M.C., Heinflink, M., Nussenzveig, D.R., Hinkle, P.M., Falck-Pedersen, E. J. Biol. Chem. (1994)
- A model of inverse agonist action at thyrotropin-releasing hormone receptor type 1: role of a conserved tryptophan in helix 6. Lu, X., Huang, W., Worthington, S., Drabik, P., Osman, R., Gershengorn, M.C. Mol. Pharmacol. (2004)
- Thyrotropin releasing hormone inhibits tau phosphorylation by dual signaling pathways in hippocampal neurons. Luo, L., Stopa, E.G. J. Alzheimers Dis. (2004)
- Activation of MAPK by TRH requires clathrin-dependent endocytosis and PKC but not receptor interaction with beta-arrestin or receptor endocytosis. Smith, J., Yu, R., Hinkle, P.M. Mol. Endocrinol. (2001)
- Thyrotropin-releasing hormone and its receptors - A hypothesis for binding and receptor activation. Engel, S., Gershengorn, M.C. Pharmacol. Ther. (2007)
- Transcription of the human thyrotropin-releasing hormone receptor gene-analysis of basal promoter elements and glucocorticoid response elements. Høvring, P.I., Matre, V., Fjeldheim, A.K., Loseth, O.P., Gautvik, K.M. Biochem. Biophys. Res. Commun. (1999)
- Estrogens increase the number of thyrotropin-releasing hormone receptors on mammotropic cells in culture. Gershengorn, M.C., Marcus-Samuels, B.E., Geras, E. Endocrinology (1979)
- Low Affinity Analogs of Thyrotropin-releasing Hormone Are Super-agonists. Engel, S., Neumann, S., Kaur, N., Monga, V., Jain, R., Northup, J., Gershengorn, M.C. J. Biol. Chem. (2006)
- Kinetics and reversibility of thyrotropin-releasing hormone-stimulated guanine nucleotide exchange in membranes from GH4C1 cells. Brady, K.D., Han, B., Tashjian, A.H. Mol. Pharmacol. (1994)
- Screening of candidate oncogenes in human thyrotroph tumors: absence of activating mutations of the G alpha q, G alpha 11, G alpha s, or thyrotropin-releasing hormone receptor genes. Dong, Q., Brucker-Davis, F., Weintraub, B.D., Smallridge, R.C., Carr, F.E., Battey, J., Spiegel, A.M., Shenker, A. J. Clin. Endocrinol. Metab. (1996)
- Activation of the thyrotropin-releasing hormone (TRH) receptor by a direct precursor of TRH, TRH-Gly. Yamada, M., Iwasaki, T., Satoh, T., Monden, T., Konaka, S., Murakami, M., Iriuchijima, T., Mori, M. Neurosci. Lett. (1995)
- Human TRH receptor messenger ribonucleic acid levels in normal and adenomatous pituitary: analysis by the competitive reverse transcription polymerase chain reaction method. Kaji, H., Xu, Y., Takahashi, Y., Abe, H., Tamaki, N., Chihara, K. Clin. Endocrinol. (Oxf) (1995)
- The detection of thyrotropin-releasing hormone (TRH) and TRH receptor gene expression in Siberian hamster testes. Rao, J.N., Debeljuk, L., Bartke, A., Gao, Y.P., Wilber, J.F., Feng, P. Peptides (1997)
- TRH receptor on immune cells: in vitro and in vivo stimulation of human lymphocyte and rat splenocyte DNA synthesis by TRH. Raiden, S., Polack, E., Nahmod, V., Labeur, M., Holsboer, F., Arzt, E. J. Clin. Immunol. (1995)