Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

Gene: TRLP1 - tRNA leucine (AAG) pseudogene 1

Homo sapiens

Synonyms:

[edit this page]

O'Brien, T., van Barlingen, H.H., Pirtle, I.L., Stacpoole, P.W., Meyer, E.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text.

Ideally this entry shall become one comprehensive and continuous article. Bulleted lists, for instance, were only used because it is impossible to automatically integrate independent facts into a continuous text.

Much of the current information on this page has been automatically compiled from Pubmed.

This precompiled information serves as a substrate and matrix to embed your contributions, but it is by no means the final word - Homo sapiens can do much better!

WikiGenes is a non-profit and open access community project.

Disease relevance of TRLP1

The results provide evidence that the metabolism of intestinal TRLP is significantly different in normolipidemic women with angiographically proven CAD compared with individually matched controls without coronary disease [1].

High impact information on TRLP1

We conclude that 1) a high carbohydrate diet results in a decrease in total, LDL, and HDL cholesterol and a trend toward an increase in plasma triglycerides; 2) fasting TRLP and HDL apo composition was similar on a high-carbohydrate or a high-fat diet; and 3) on both diets, apo CII, CIII, and E transfer from HDL to TRLP postprandially [2].
Competition studies revealed that b-HS binding to TRLP was fully displaceable by lactoferrin but barely by heparan sulfate, dermatan sulfate, or chondroitin-4-sulfate [3].
The cell-free system that was used enabled us to identify the functions of apoC and apoE in the binding of TRLP to LPL and HSPG [3].
TRLP1 has three nucleotide variations (97% identity) from its cognate leucine tRNA(IAG), while TRMEP1 has a 78% identity with its cognate tRNA [4].
On the omega-6 diet, both subjects demonstrated four- to five-times normal rates of TRLP-TG production and glycerol biosynthesis, and striking decrements in the fractional catabolic rate (FCR) for TRLP-TG and TRLP-particles [5].

Biological context of TRLP1

A leucine tRNA(AAG) pseudogene (TRLP1) is 2.1-kb upstream and of opposite polarity to a methionine elongator tRNA(CAU) pseudogene (TRMEP1) [4].

Analytical, diagnostic and therapeutic context of TRLP1

TRLP, low density lipoproteins (LDL), and HDL were separated by fast protein liquid chromatography [2].

References

Abnormal postprandial apolipoprotein B-48 and triglyceride responses in normolipidemic women with greater than 70% stenotic coronary artery disease: a case-control study. Meyer, E., Westerveld, H.T., de Ruyter-Meijstek, F.C., van Greevenbroek, M.M., Rienks, R., van Rijn, H.J., Erkelens, D.W., de Bruin, T.W. Atherosclerosis (1996)
Lipoprotein compositional changes in the fasting and postprandial state on a high-carbohydrate low-fat and a high-fat diet in subjects with noninsulin-dependent diabetes mellitus. O'Brien, T., Nguyen, T.T., Buithieu, J., Kottke, B.A. J. Clin. Endocrinol. Metab. (1993)
Lipoprotein lipase-enhanced binding of human triglyceride-rich lipoproteins to heparan sulfate: modulation by apolipoprotein E and apolipoprotein C. van Barlingen, H.H., de Jong, H., Erkelens, D.W., de Bruin, T.W. J. Lipid Res. (1996)
A human DNA segment encompassing leucine and methionine tRNA pseudogenes localized on chromosome 6. Pirtle, I.L., Chang, Y.N., Lee, M.M., Yi, H.F., Wang, S.Y., McBride, O.W., Pirtle, R.M. Gene (1993)
Lipodystrophic diabetes mellitus. Investigations of lipoprotein metabolism and the effects of omega-3 fatty acid administration in two patients. Stacpoole, P.W., Alig, J., Kilgore, L.L., Ayala, C.M., Herbert, P.N., Zech, L.A., Fisher, W.R. Metab. Clin. Exp. (1988)