Gene Review:
TRPS1 - trichorhinophalangeal syndrome I
Homo sapiens
Synonyms:
GC79, LGCR, Tricho-rhino-phalangeal syndrome type I protein, Zinc finger protein GC79, Zinc finger transcription factor Trps1
Lüdecke,
Schmidt,
Nardmann,
von Holtum,
Meinecke,
Muenke,
Horsthemke,
Kaiser,
Lüdecke,
Weger,
Chang,
van den Bemd,
Jhamai,
Brinkmann,
Lüdecke,
Schaper,
Meinecke,
Momeni,
Gross,
von Holtum D,
Hirche,
Abramowicz,
Albrecht,
Apacik,
Christen,
Claussen,
Devriendt,
Fastnacht,
Forderer,
Friedrich,
Goodship,
Greiwe,
Hamm,
Hennekam,
Hinkel,
Hoeltzenbein,
Kayserili,
Majewski,
Mathieu,
McLeod,
Midro,
Moog,
Nagai,
Niikawa,
Orstavik,
Plöchl,
Seitz,
Schmidtke,
Tranebjaerg,
Tsukahara,
Wittwer,
Zabel,
Gillessen-Kaesbach,
Horsthemke,
Kobayashi,
Hino,
Shimodahira,
Iwakura,
Ishihara,
Ikekubo,
Ogawa,
Nakao,
Kurahachi,
Radvanyi,
Singh-Sandhu,
Gallichan,
Lovitt,
Pedyczak,
Mallo,
Gish,
Kwok,
Hanna,
Zubovits,
Armes,
Venter,
Hakimi,
Shortreed,
Donovan,
Parrington,
Dunn,
Oomen,
Tartaglia,
Berinstein,
Chang,
Jhamai,
van Weerden,
Jenster,
Brinkmann,
- A 4-megabase YAC contig that spans the Langer-Giedion syndrome region on human chromosome 8q24.1: use in refining the location of the trichorhinophalangeal syndrome and multiple exostoses genes (TRPS1 and EXT1). Hou, J., Parrish, J., Lüdecke, H.J., Sapru, M., Wang, Y., Chen, W., Hill, A., Siegel-Bartelt, J., Northrup, H., Elder, F.F. Genomics (1995)
- Expression and copy number analysis of TRPS1, EIF3S3 and MYC genes in breast and prostate cancer. Savinainen, K.J., Linja, M.J., Saramäki, O.R., Tammela, T.L., Chang, G.T., Brinkmann, A.O., Visakorpi, T. Br. J. Cancer (2004)
- The atypical GATA protein TRPS1 represses androgen-induced prostate-specific antigen expression in LNCaP prostate cancer cells. van den Bemd, G.J., Jhamai, M., Brinkmann, A.O., Chang, G.T. Biochem. Biophys. Res. Commun. (2003)
- Genes and chromosomal breakpoints in the Langer-Giedion syndrome region on human chromosome 8. Lüdecke, H.J., Schmidt, O., Nardmann, J., von Holtum, D., Meinecke, P., Muenke, M., Horsthemke, B. Hum. Genet. (1999)
- A 4 Mb cryptic deletion associated with inv(8)(q13.1q24.11) in a patient with trichorhinophalangeal syndrome type I. Sasaki, T., Tonoki, H., Soejima, H., Niikawa, N. J. Med. Genet. (1997)
- Mutations in a new gene, encoding a zinc-finger protein, cause tricho-rhino-phalangeal syndrome type I. Momeni, P., Glöckner, G., Schmidt, O., von Holtum, D., Albrecht, B., Gillessen-Kaesbach, G., Hennekam, R., Meinecke, P., Zabel, B., Rosenthal, A., Horsthemke, B., Lüdecke, H.J. Nat. Genet. (2000)
- Transcriptional repression and developmental functions of the atypical vertebrate GATA protein TRPS1. Malik, T.H., Shoichet, S.A., Latham, P., Kroll, T.G., Peters, L.L., Shivdasani, R.A. EMBO J. (2001)
- The gene associated with trichorhinophalangeal syndrome in humans is overexpressed in breast cancer. Radvanyi, L., Singh-Sandhu, D., Gallichan, S., Lovitt, C., Pedyczak, A., Mallo, G., Gish, K., Kwok, K., Hanna, W., Zubovits, J., Armes, J., Venter, D., Hakimi, J., Shortreed, J., Donovan, M., Parrington, M., Dunn, P., Oomen, R., Tartaglia, J., Berinstein, N.L. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Genotypic and phenotypic spectrum in tricho-rhino-phalangeal syndrome types I and III. Lüdecke, H.J., Schaper, J., Meinecke, P., Momeni, P., Gross, S., von Holtum D, n.u.l.l., Hirche, H., Abramowicz, M.J., Albrecht, B., Apacik, C., Christen, H.J., Claussen, U., Devriendt, K., Fastnacht, E., Forderer, A., Friedrich, U., Goodship, T.H., Greiwe, M., Hamm, H., Hennekam, R.C., Hinkel, G.K., Hoeltzenbein, M., Kayserili, H., Majewski, F., Mathieu, M., McLeod, R., Midro, A.T., Moog, U., Nagai, T., Niikawa, N., Orstavik, K.H., Plöchl, E., Seitz, C., Schmidtke, J., Tranebjaerg, L., Tsukahara, M., Wittwer, B., Zabel, B., Gillessen-Kaesbach, G., Horsthemke, B. Am. J. Hum. Genet. (2001)
- Missense mutation of TRPS1 in a family of tricho-rhino-phalangeal syndrome type III. Kobayashi, H., Hino, M., Shimodahira, M., Iwakura, T., Ishihara, T., Ikekubo, K., Ogawa, Y., Nakao, K., Kurahachi, H. Am. J. Med. Genet. (2002)
- Analysis of novel and recurrent mutations responsible for the tricho-rhino-phalangeal syndromes. Hilton, M.J., Sawyer, J.M., Gutiérrez, L., Hogart, A., Kung, T.C., Wells, D.E. J. Hum. Genet. (2002)
- Nuclear interaction of the dynein light chain LC8a with the TRPS1 transcription factor suppresses the transcriptional repression activity of TRPS1. Kaiser, F.J., Tavassoli, K., Van den Bemd, G.J., Chang, G.T., Horsthemke, B., Möröy, T., Lüdecke, H.J. Hum. Mol. Genet. (2003)
- Deletion of the GATA domain of TRPS1 causes an absence of facial hair and provides new insights into the bone disorder in inherited tricho-rhino-phalangeal syndromes. Malik, T.H., Von Stechow, D., Bronson, R.T., Shivdasani, R.A. Mol. Cell. Biol. (2002)
- The TRPS1 transcription factor: androgenic regulation in prostate cancer and high expression in breast cancer. Chang, G.T., Jhamai, M., van Weerden, W.M., Jenster, G., Brinkmann, A.O. Endocr. Relat. Cancer (2004)
- Novel missense mutations in the TRPS1 transcription factor define the nuclear localization signal. Kaiser, F.J., Brega, P., Raff, M.L., Byers, P.H., Gallati, S., Kay, T.T., de Almeida, S., Horsthemke, B., Lüdecke, H.J. Eur. J. Hum. Genet. (2004)
- SUMOylation modulates transcriptional repression by TRPS1. Kaiser, F.J., Lüdecke, H.J., Weger, S. Biol. Chem. (2007)
- Quantitative measurements of the changes in protein thiols in cervical intraepithelial neoplasia and in carcinoma of the human uterine cervix provide evidence for the existence of a biochemical field effect. Benedetto, C., Bajardi, F., Ghiringhello, B., Marozio, L., Nöhammer, G., Phitakpraiwan, P., Rojanapo, W., Schauenstein, E., Slater, T.F. Cancer Res. (1990)
- High-yield functional expression of human sodium/d-glucose cotransporter1 in Pichia pastoris and characterization of ligand-induced conformational changes as studied by tryptophan fluorescence. Tyagi, N.K., Goyal, P., Kumar, A., Pandey, D., Siess, W., Kinne, R.K. Biochemistry (2005)
- Neocarzinostatin: selective tryptophan oxidation and neocarzinostatin-chromophore binding to apo-neocarzinostatin. Edo, K., Saito, K., Matsuda, Y., Akiyama-Murai, Y., Mizugaki, M., Koide, Y., Ishida, N. Chem. Pharm. Bull. (1991)
- The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor. Kaiser, F.J., Möröy, T., Chang, G.T., Horsthemke, B., Lüdecke, H.J. J. Biol. Chem. (2003)
- Mutations and promoter SNPs in RUNX2, a transcriptional regulator of bone formation. Napierala, D., Garcia-Rojas, X., Sam, K., Wakui, K., Chen, C., Mendoza-Londono, R., Zhou, G., Zheng, Q., Lee, B. Mol. Genet. Metab. (2005)
- The EIF3S3 gene encoding the p40 subunit of the translation initiation factor eIF3 has eight exons and maps to the Langer-Giedion syndrome chromosome region on 8q24, but is not the TRPS1 gene. Schmidt, O., von Holtum, D., Gross, S., Horsthemke, B., Lüdecke, H.J. Hum. Genet. (1999)
- Structure and function of GC79/TRPS1, a novel androgen-repressible apoptosis gene. Chang, G.T., van den Bemd, G.J., Jhamai, M., Brinkmann, A.O. Apoptosis (2002)