Gene Review:
C5 - complement component 5
Homo sapiens
Synonyms:
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, C5D, C5a, C5b, CPAMD4, ...
- Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma. Hasegawa, K., Tamari, M., Shao, C., Shimizu, M., Takahashi, N., Mao, X.Q., Yamasaki, A., Kamada, F., Doi, S., Fujiwara, H., Miyatake, A., Fujita, K., Tamura, G., Matsubara, Y., Shirakawa, T., Suzuki, Y. Hum. Genet. (2004)
- Complement C5 in experimental autoimmune encephalomyelitis (EAE) facilitates remyelination and prevents gliosis. Weerth, S.H., Rus, H., Shin, M.L., Raine, C.S. Am. J. Pathol. (2003)
- Isolation and sequence analysis of a cDNA clone encoding the fifth complement component. Lundwall, A.B., Wetsel, R.A., Kristensen, T., Whitehead, A.S., Woods, D.E., Ogden, R.C., Colten, H.R., Tack, B.F. J. Biol. Chem. (1985)
- A protective role for the fifth complement component (c5) in allergic airway disease. Drouin, S.M., Sinha, M., Sfyroera, G., Lambris, J.D., Wetsel, R.A. Am. J. Respir. Crit. Care Med. (2006)
- Increased expression of proteasome subunits in skeletal muscle of cancer patients with weight loss. Khal, J., Hine, A.V., Fearon, K.C., Dejong, C.H., Tisdale, M.J. Int. J. Biochem. Cell Biol. (2005)
- Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. Hillebrandt, S., Wasmuth, H.E., Weiskirchen, R., Hellerbrand, C., Keppeler, H., Werth, A., Schirin-Sokhan, R., Wilkens, G., Geier, A., Lorenzen, J., Köhl, J., Gressner, A.M., Matern, S., Lammert, F. Nat. Genet. (2005)
- Myasthenia gravis. Study of humoral immune mechanisms by passive transfer to mice. Toyka, K.V., Drachman, D.B., Griffin, D.E., Pestronk, A., Winkelstein, J.A., Fishbeck, K.H., Kao, I. N. Engl. J. Med. (1977)
- Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma. Karp, C.L., Grupe, A., Schadt, E., Ewart, S.L., Keane-Moore, M., Cuomo, P.J., Köhl, J., Wahl, L., Kuperman, D., Germer, S., Aud, D., Peltz, G., Wills-Karp, M. Nat. Immunol. (2000)
- Trypsin-activated complex of human factor B with cobra venom factor (CVF), cleaving C3 and C5 and generating a lytic factor for unsensitized guinea pig erythrocytes. I. Generation of the activated complex. Miyama, A., Kato, T., Horai, S., Yokoo, J., Kashiba, S. Biken journal. (1975)
- Stereospecific elimination of hydrogen at C-10 in eicosapentaenoic acid during the conversion to leukotriene C5. Hammarström, S. J. Biol. Chem. (1983)
- Bacteriochlorophyll c formation via the C5 pathway of 5-aminolevulinic acid synthesis in Chloroflexus aurantiacus. Oh-hama, T., Santander, P.J., Stolowich, N.J., Scott, A.I. FEBS Lett. (1991)
- Intramedullary cystic teratoid tumor of the cervical spinal cord in association with a teratoma of the ovary. Cybulski, G.R., Von Roenn, K.A., Bailey, O.T. Surgical neurology. (1984)
- Hepatocyte nuclear factor 1alpha controls the expression of terminal complement genes. Pontoglio, M., Pausa, M., Doyen, A., Viollet, B., Yaniv, M., Tedesco, F. J. Exp. Med. (2001)
- Inhibition of C5a-induced inflammation with preserved C5b-9-mediated bactericidal activity in a human whole blood model of meningococcal sepsis. Sprong, T., Brandtzaeg, P., Fung, M., Pharo, A.M., Høiby, E.A., Michaelsen, T.E., Aase, A., van der Meer, J.W., van Deuren, M., Mollnes, T.E. Blood (2003)
- Evidence that C5b recognizes and mediates C8 incorporation into the cytolytic complex of complement. Stewart, J.L., Kolb, W.P., Sodetz, J.M. J. Immunol. (1987)
- Linking C5 deficiency to an exonic splicing enhancer mutation. Pfarr, N., Prawitt, D., Kirschfink, M., Schroff, C., Knuf, M., Habermehl, P., Mannhardt, W., Zepp, F., Fairbrother, W., Loos, M., Burge, C.B., Pohlenz, J. J. Immunol. (2005)
- rC5a directs the in vitro migration of human memory and naive tonsillar B lymphocytes: implications for B cell trafficking in secondary lymphoid tissues. Ottonello, L., Corcione, A., Tortolina, G., Airoldi, I., Albesiano, E., Favre, A., D'Agostino, R., Malavasi, F., Pistoia, V., Dallegri, F. J. Immunol. (1999)
- Hereditary C5 deficiency in man: genetic linkage studies. Rosenfeld, S.I., Weitkamp, L.R., Ward, F. J. Immunol. (1977)
- Complete cDNA sequence of human complement pro-C5. Evidence of truncated transcripts derived from a single copy gene. Haviland, D.L., Haviland, J.C., Fleischer, D.T., Hunt, A., Wetsel, R.A. J. Immunol. (1991)
- Expression and characterization of the C345C/NTR domains of complement components C3 and C5. Thai, C.T., Ogata, R.T. J. Immunol. (2003)
- Complement C3b interactions studied with surface plasmon resonance technique. Jokiranta, T.S., Westin, J., Nilsson, U.R., Nilsson, B., Hellwage, J., Löfås, S., Gordon, D.L., Ekdahl, K.N., Meri, S. Int. Immunopharmacol. (2001)
- Primary structural analysis of the polypeptide portion of human C5a anaphylatoxin. Polypeptide sequence determination and assignment of the oligosaccharide attachment site in C5a. Fernandez, H.N., Hugli, T.E. J. Biol. Chem. (1978)
- Complement components C5 and C7: recombinant factor I modules of C7 bind to the C345C domain of C5. Thai, C.T., Ogata, R.T. J. Immunol. (2004)
- Surface-dependent modulation by H of C5 cleavage by the cell-bound alternative pathway C5 convertase of human complement. Fischer, E., Kazatchkine, M.D. J. Immunol. (1983)
- Complement activation by myeloperoxidase products released from stimulated human polymorphonuclear leukocytes. Vogt, W. Immunobiology (1996)
- Formation and structure of the C5b-7 complex of the lytic pathway of complement. DiScipio, R.G. J. Biol. Chem. (1992)
- Metabolism of the fifth component of complement, and its relation to metabolism of the third component, in patients with complement activation. Sissons, J.G., Liebowitch, J., Amos, N., Peters, D.K. J. Clin. Invest. (1977)
- Inherited human complement C5 deficiency. Nonsense mutations in exons 1 (Gln1 to Stop) and 36 (Arg1458 to Stop) and compound heterozygosity in three African-American families. Wang, X., Fleischer, D.T., Whitehead, W.T., Haviland, D.L., Rosenfeld, S.I., Leddy, J.P., Snyderman, R., Wetsel, R.A. J. Immunol. (1995)
- Molecular analysis of human complement component C5: localization of the structural gene to chromosome 9. Wetsel, R.A., Lemons, R.S., Le Beau, M.M., Barnum, S.R., Noack, D., Tack, B.F. Biochemistry (1988)