Gene Review:
UBE2I - ubiquitin-conjugating enzyme E2I
Homo sapiens
Synonyms:
C358B7.1, P18, SUMO-conjugating enzyme UBC9, SUMO-protein ligase, UBC9, ...
- Functional Interaction between Human Herpesvirus 6 Immediate-Early 2 Protein and Ubiquitin-Conjugating Enzyme 9 in the Absence of Sumoylation. Tomoiu, A., Gravel, A., Tanguay, R.M., Flamand, L. J. Virol. (2006)
- Evaluation of interactions of human cytomegalovirus immediate-early IE2 regulatory protein with small ubiquitin-like modifiers and their conjugation enzyme Ubc9. Ahn, J.H., Xu, Y., Jang, W.J., Matunis, M.J., Hayward, G.S. J. Virol. (2001)
- Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer. Okamoto, A., Hussain, S.P., Hagiwara, K., Spillare, E.A., Rusin, M.R., Demetrick, D.J., Serrano, M., Hannon, G.J., Shiseki, M., Zariwala, M. Cancer Res. (1995)
- A role for Ubc9 in tumorigenesis. Mo, Y.Y., Yu, Y., Theodosiou, E., Rachel Ee, P.L., Beck, W.T. Oncogene (2005)
- Covalent modification of human immunodeficiency virus type 1 p6 by SUMO-1. Gurer, C., Berthoux, L., Luban, J. J. Virol. (2005)
- Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1. Bernier-Villamor, V., Sampson, D.A., Matunis, M.J., Lima, C.D. Cell (2002)
- Multiple activities contribute to Pc2 E3 function. Kagey, M.H., Melhuish, T.A., Powers, S.E., Wotton, D. EMBO J. (2005)
- PIASy mediates SUMO-2 conjugation of Topoisomerase-II on mitotic chromosomes. Azuma, Y., Arnaoutov, A., Anan, T., Dasso, M. EMBO J. (2005)
- Covalent modification of the androgen receptor by small ubiquitin-like modifier 1 (SUMO-1). Poukka, H., Karvonen, U., Janne, O.A., Palvimo, J.J. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Modulation of TEL transcription activity by interaction with the ubiquitin-conjugating enzyme UBC9. Chakrabarti, S.R., Sood, R., Ganguly, S., Bohlander, S., Shen, Z., Nucifora, G. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Induction of anti-gp160 cytotoxic T cells cross-reacting with various V3 loop P18 peptides in human immunodeficiency virus type 1 envelope-immunized individuals. Achour, A., Bex, F., Hermans, P., Burny, A., Zagury, D. J. Virol. (1996)
- Cloning, expression, and mapping of UBE2I, a novel gene encoding a human homologue of yeast ubiquitin-conjugating enzymes which are critical for regulating the cell cycle. Watanabe, T.K., Fujiwara, T., Kawai, A., Shimizu, F., Takami, S., Hirano, H., Okuno, S., Ozaki, K., Takeda, S., Shimada, Y., Nagata, M., Takaichi, A., Takahashi, E., Nakamura, Y., Shin, S. Cytogenet. Cell Genet. (1996)
- Identification of a substrate recognition site on Ubc9. Lin, D., Tatham, M.H., Yu, B., Kim, S., Hay, R.T., Chen, Y. J. Biol. Chem. (2002)
- Ubc9-induced inhibition of diadenosine triphosphate hydrolase activity of the putative tumor suppressor protein Fhit. Golebiowski, F., Szulc, A., Szutowicz, A., Pawelczyk, T. Arch. Biochem. Biophys. (2004)
- Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex. Zhang, H., Saitoh, H., Matunis, M.J. Mol. Cell. Biol. (2002)
- Association of activating transcription factor 2 (ATF2) with the ubiquitin-conjugating enzyme hUBC9. Implication of the ubiquitin/proteasome pathway in regulation of ATF2 in T cells. Firestein, R., Feuerstein, N. J. Biol. Chem. (1998)
- Ubc9 and Protein Inhibitor of Activated STAT 1 Activate Chicken Ovalbumin Upstream Promoter-Transcription Factor I-mediated Human CYP11B2 Gene Transcription. Kurihara, I., Shibata, H., Kobayashi, S., Suda, N., Ikeda, Y., Yokota, K., Murai, A., Saito, I., Rainey, W.E., Saruta, T. J. Biol. Chem. (2005)
- Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358. Saitoh, H., Pizzi, M.D., Wang, J. J. Biol. Chem. (2002)
- Regulation of microphthalmia-associated transcription factor MITF protein levels by association with the ubiquitin-conjugating enzyme hUBC9. Xu, W., Gong, L., Haddad, M.M., Bischof, O., Campisi, J., Yeh, E.T., Medrano, E.E. Exp. Cell Res. (2000)
- Overexpression of a dominant-negative mutant Ubc9 is associated with increased sensitivity to anticancer drugs. Mo, Y.Y., Yu, Y., Ee, P.L., Beck, W.T. Cancer Res. (2004)
- A Kruppel zinc finger of ZNF 146 interacts with the SUMO-1 conjugating enzyme UBC9 and is sumoylated in vivo. Antoine, K., Prosperi, M.T., Ferbus, D., Boule, C., Goubin, G. Mol. Cell. Biochem. (2005)
- Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection. Tatham, M.H., Kim, S., Jaffray, E., Song, J., Chen, Y., Hay, R.T. Nat. Struct. Mol. Biol. (2005)
- Solution structure of human SUMO-3 C47S and its binding surface for Ubc9. Ding, H., Xu, Y., Chen, Q., Dai, H., Tang, Y., Wu, J., Shi, Y. Biochemistry (2005)
- The homeodomain-interacting kinase PKM (HIPK-2) modifies ND10 through both its kinase domain and a SUMO-1 interaction motif and alters the posttranslational modification of PML. Engelhardt, O.G., Boutell, C., Orr, A., Ullrich, E., Haller, O., Everett, R.D. Exp. Cell Res. (2003)
- Ubc9 interacts with SOX4 and represses its transcriptional activity. Pan, X., Li, H., Zhang, P., Jin, B., Man, J., Tian, L., Su, G., Zhao, J., Li, W., Liu, H., Gong, W., Zhou, T., Zhang, X. Biochem. Biophys. Res. Commun. (2006)
- Association of FHIT (fragile histidine triad), a candidate tumour suppressor gene, with the ubiquitin-conjugating enzyme hUBC9. Shi, Y., Zou, M., Farid, N.R., Paterson, M.C. Biochem. J. (2000)
- SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4. Lin, X., Liang, M., Liang, Y.Y., Brunicardi, F.C., Feng, X.H. J. Biol. Chem. (2003)
- Differential modulation of androgen receptor action by deoxyribonucleic acid response elements. Geserick, C., Meyer, H.A., Barbulescu, K., Haendler, B. Mol. Endocrinol. (2003)
- Suppression of ARG kinase activity by STI571 induces cell cycle arrest through up-regulation of CDK inhibitor p18/INK4c. Nishimura, N., Furukawa, Y., Sutheesophon, K., Nakamura, M., Kishi, K., Okuda, K., Sato, Y., Kano, Y. Oncogene (2003)
- SUMO-1 modification activates the transcriptional response of p53. Rodriguez, M.S., Desterro, J.M., Lain, S., Midgley, C.A., Lane, D.P., Hay, R.T. EMBO J. (1999)
- Sterol regulatory element-binding proteins are negatively regulated through SUMO-1 modification independent of the ubiquitin/26 S proteasome pathway. Hirano, Y., Murata, S., Tanaka, K., Shimizu, M., Sato, R. J. Biol. Chem. (2003)
- The DNA topoisomerase I binding protein topors as a novel cellular target for SUMO-1 modification: characterization of domains necessary for subcellular localization and sumolation. Weger, S., Hammer, E., Engstler, M. Exp. Cell Res. (2003)
- Interaction of the developmental regulator SALL1 with UBE2I and SUMO-1. Netzer, C., Bohlander, S.K., Rieger, L., Müller, S., Kohlhase, J. Biochem. Biophys. Res. Commun. (2002)
- Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation. Tatham, M.H., Kim, S., Yu, B., Jaffray, E., Song, J., Zheng, J., Rodriguez, M.S., Hay, R.T., Chen, Y. Biochemistry (2003)
- Analysis of the cyclin-dependent kinase inhibitors p18 and p19 in mantle-cell lymphoma and chronic lymphocytic leukemia. Williams, M.E., Whitefield, M., Swerdlow, S.H. Ann. Oncol. (1997)
- Nucleus-encoded histone H1-like proteins are associated with kinetoplast DNA in the trypanosomatid Crithidia fasciculata. Xu, C.W., Hines, J.C., Engel, M.L., Russell, D.G., Ray, D.S. Mol. Cell. Biol. (1996)
- Kaposi's sarcoma-associated herpesvirus K-bZIP represses gene transcription via SUMO modification. Izumiya, Y., Ellison, T.J., Yeh, E.T., Jung, J.U., Luciw, P.A., Kung, H.J. J. Virol. (2005)
- Regulation of bcl-2 expression by Ubc9. Lu, Z., Wu, H., Mo, Y.Y. Exp. Cell Res. (2006)