The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

UBE2V2  -  ubiquitin-conjugating enzyme E2 variant 2

Homo sapiens

Synonyms: DDVIT1, DDVit 1, DDVit-1, EDAF-1, EDPF-1, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of UBE2V2

 

High impact information on UBE2V2

  • The MMS2-encoded UEV protein has been genetically implicated in error-free postreplicative DNA repair in Saccharomyces cerevisiae [3].
  • Aurora-A in a complex with UBE2N/MMS2 catalyses polyubiquitination of IkappaBalpha in vitro and in vivo [4].
  • Both RWLeu-4 and JMRD3 express similar vitamin D3 receptors and vitamin D3-inducible enzyme activities [5].
  • Ang II induced MMS2 expression in a dose-dependent manner, reaching a peak after 4 h of stimulation, and this effect was enhanced with AT(1) receptor blocker, valsartan, but inhibited by AT(2) receptor blocker PD123319 [6].
  • These results provide a new insight into the contribution of AT(2) receptor stimulation to neural differentiation via transactivation of MMS2 expression involving the association of ATIP and SHP-1 [6].
 

Chemical compound and disease context of UBE2V2

  • Comparisons of their sensitivities to the bifunctional alkylating agents cis-platinum (II) diammine dichloride, mitomycin C and melphalan reveals marked phenotypic diversity, with only one mutant, designated MMS-2, exhibiting appreciable hypersensitivity to all of these agents [7].
 

Biological context of UBE2V2

  • To ask whether a similar mechanism contributes to abasic site-induced immunoglobulin gene conversion, and to ascertain the role of UBE2V2 in the vertebrate DNA damage response we created a ube2v2 mutant of the chicken cell line DT40 [1].
  • The hMMS2 and CROC-1 genes are able to functionally complement the yeast mms2 defects with regard to sensitivity to DNA damaging agents and spontaneous mutagenesis [8].
  • Using the rapid amplification of cDNA Ends (RACE)-PCR we got a transcript (DDVit 1) of a length of 1251 bp containing an open reading frame that encodes a putative 16,5 kD protein [9].
  • Conversely, both MMS2 and hMMS2 were able to transactivate a c- fos - CAT reporter gene in Rat-1 cells in a transient co-transfection assay [8].
  • A mutation in genes of either the MMS2 or the REV3 branch does not result in extreme sensitivity to DNA-damaging agents; however, deletion of both subpathways of PRR results in a synergistic phenotype [10].
 

Anatomical context of UBE2V2

 

Associations of UBE2V2 with chemical compounds

 

Other interactions of UBE2V2

  • The microarray showed that the most strongly up-regulated gene by 5-FU was vitamin D3 up-regulated protein 1 (VDUP1), an interesting stress response gene, which was originally reported as a vitamin D3 inducible gene in HL-60 [13].

References

  1. UBE2V2 (MMS2) is not required for effective immunoglobulin gene conversion or DNA damage tolerance in DT40. Simpson, L.J., Sale, J.E. DNA Repair (Amst.) (2005) [Pubmed]
  2. Bedside multimarker testing for risk stratification in chest pain units: The chest pain evaluation by creatine kinase-MB, myoglobin, and troponin I (CHECKMATE) study. Newby, L.K., Storrow, A.B., Gibler, W.B., Garvey, J.L., Tucker, J.F., Kaplan, A.L., Schreiber, D.H., Tuttle, R.H., McNulty, S.E., Ohman, E.M. Circulation (2001) [Pubmed]
  3. Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. Hofmann, R.M., Pickart, C.M. Cell (1999) [Pubmed]
  4. The N-terminal domain of the Aurora-A Phe-31 variant encodes an E3 ubiquitin ligase and mediates ubiquitination of I{kappa}B{alpha}. Briassouli, P., Chan, F., Linardopoulos, S. Hum. Mol. Genet. (2006) [Pubmed]
  5. Characterization of a vitamin D3-resistant human chronic myelogenous leukemia cell line. Lasky, S.R., Posner, M.R., Iwata, K., Santos-Moore, A., Yen, A., Samuel, V., Clark, J., Maizel, A.L. Blood (1994) [Pubmed]
  6. Angiotensin II-Induced Neural Differentiation via Angiotensin II Type 2 (AT2) Receptor-MMS2 Cascade Involving Interaction between AT2 Receptor-Interacting Protein and Src Homology 2 Domain-Containing Protein-Tyrosine Phosphatase 1. Li, J.M., Mogi, M., Tsukuda, K., Tomochika, H., Iwanami, J., Min, L.J., Nahmias, C., Iwai, M., Horiuchi, M. Mol. Endocrinol. (2007) [Pubmed]
  7. Isolation of alkylating agent-sensitive Chinese hamster ovary cell lines. Robson, C.N., Hickson, I.D. Carcinogenesis (1987) [Pubmed]
  8. The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family. Xiao, W., Lin, S.L., Broomfield, S., Chow, B.L., Wei, Y.F. Nucleic Acids Res. (1998) [Pubmed]
  9. Molecular cloning of a 1alpha,25-dihydroxyvitamin D3-inducible transcript (DDVit 1) in human blood monocytes. Fritsche, J., Rehli, M., Krause, S.W., Andreesen, R., Kreutz, M. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  10. DNA damage checkpoints are involved in postreplication repair. Barbour, L., Ball, L.G., Zhang, K., Xiao, W. Genetics (2006) [Pubmed]
  11. C2-ceramide induces apoptosis in a human squamous cell carcinoma cell line. Sugiki, H., Hozumi, Y., Maeshima, H., Katagata, Y., Mitsuhashi, Y., Kondo, S. Br. J. Dermatol. (2000) [Pubmed]
  12. Differential effects on cell killing in metallothionein overexpressing CHO mutant cell lines. Lohrer, H., Robson, T., Grindley, H., Foster, S., Hall, A. Carcinogenesis (1990) [Pubmed]
  13. Up-regulation of vitamin D3 up-regulated protein 1 gene in response to 5-fluorouracil in colon carcinoma SW620. Takahashi, Y., Nagata, T., Ishii, Y., Ikarashi, M., Ishikawa, K., Asai, S. Oncol. Rep. (2002) [Pubmed]
 
WikiGenes - Universities