Gene Review:
SLC35A2 - solute carrier family 35 (UDP-galactose...
Homo sapiens
Synonyms:
CDG2M, CDGX, Solute carrier family 35 member A2, UDP-Gal-Tr, UDP-galactose translocator, ...
- Increased expression of UDP-galactose transporter messenger RNA in human colon cancer tissues and its implication in synthesis of Thomsen-Friedenreich antigen and sialyl Lewis A/X determinants. Kumamoto, K., Goto, Y., Sekikawa, K., Takenoshita, S., Ishida, N., Kawakita, M., Kannagi, R. Cancer Res. (2001)
- Correction of the UDP-glucuronosyltransferase gene defect in the gunn rat model of crigler-najjar syndrome type I with a chimeric oligonucleotide. Kren, B.T., Parashar, B., Bandyopadhyay, P., Chowdhury, N.R., Chowdhury, J.R., Steer, C.J. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Crigler-Najjar syndrome type II is inherited both as a dominant and as a recessive trait. Koiwai, O., Aono, S., Adachi, Y., Kamisako, T., Yasui, Y., Nishizawa, M., Sato, H. Hum. Mol. Genet. (1996)
- Potential genoprotective role for UDP-glucuronosyltransferases in chemical carcinogenesis: initiation of micronuclei by benzo(a)pyrene and benzo(e)pyrene in UDP-glucuronosyltransferase-deficient cultured rat skin fibroblasts. Vienneau, D.S., DeBoni, U., Wells, P.G. Cancer Res. (1995)
- Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 and association with breast cancer among African Americans. Guillemette, C., Millikan, R.C., Newman, B., Housman, D.E. Cancer Res. (2000)
- Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Tukey, R.H., Strassburg, C.P. Annu. Rev. Pharmacol. Toxicol. (2000)
- Identification of a genetic alteration in the code for bilirubin UDP-glucuronosyltransferase in the UGT1 gene complex of a Crigler-Najjar type I patient. Ritter, J.K., Yeatman, M.T., Ferreira, P., Owens, I.S. J. Clin. Invest. (1992)
- UDP-glucuronosyltransferase activity in human liver and colon. Strassburg, C.P., Nguyen, N., Manns, M.P., Tukey, R.H. Gastroenterology (1999)
- Analysis of genes for bilirubin UDP-glucuronosyltransferase in Gilbert's syndrome. Aono, S., Adachi, Y., Uyama, E., Yamada, Y., Keino, H., Nanno, T., Koiwai, O., Sato, H. Lancet (1995)
- Gilbert's disease and atazanavir: From phenotype to UDP-glucuronosyltransferase haplotype. Lankisch, T.O., Moebius, U., Wehmeier, M., Behrens, G., Manns, M.P., Schmidt, R.E., Strassburg, C.P. Hepatology (2006)
- Regulation of steroid glucuronosyltransferase activities and transcripts by androgen in the human prostatic cancer LNCaP cell line. Guillemette, C., Hum, D.W., Bélanger, A. Endocrinology (1996)
- Estrogen regulation of the glucuronidation enzyme UGT2B15 in estrogen receptor-positive breast cancer cells. Harrington, W.R., Sengupta, S., Katzenellenbogen, B.S. Endocrinology (2006)
- Glucuronidation as a mechanism of intrinsic drug resistance in colon cancer cells: contribution of drug transport proteins. Cummings, J., Zelcer, N., Allen, J.D., Yao, D., Boyd, G., Maliepaard, M., Friedberg, T.H., Smyth, J.F., Jodrell, D.I. Biochem. Pharmacol. (2004)
- Galactose is needed only for expression of co-receptors used by Theiler's murine encephalomyelitis virus as the virus does not directly bind galactose or use the UDP-galactose transporter as a receptor. Reddi, H.V., Kallio, P., Lipton, H.L. J. Gen. Virol. (2003)
- Substrate recognition by UDP-galactose and CMP-sialic acid transporters. Different sets of transmembrane helices are utilized for the specific recognition of UDP-galactose and CMP-sialic acid. Aoki, K., Ishida, N., Kawakita, M. J. Biol. Chem. (2001)
- Molecular cloning of the hamster CMP-sialic acid transporter. Eckhardt, M., Gerardy-Schahn, R. Eur. J. Biochem. (1997)
- Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family. Ishida, N., Miura, N., Yoshioka, S., Kawakita, M. J. Biochem. (1996)
- Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. Mackenzie, P.I., Walter Bock, K., Burchell, B., Guillemette, C., Ikushiro, S., Iyanagi, T., Miners, J.O., Owens, I.S., Nebert, D.W. Pharmacogenet. Genomics (2005)
- Expression of the human UDP-galactose transporter in the Golgi membranes of murine Had-1 cells that lack the endogenous transporter. Yoshioka, S., Sun-Wada, G.H., Ishida, N., Kawakita, M. J. Biochem. (1997)
- Association of the Golgi UDP-galactose transporter with UDP-galactose:ceramide galactosyltransferase allows UDP-galactose import in the endoplasmic reticulum. Sprong, H., Degroote, S., Nilsson, T., Kawakita, M., Ishida, N., van der Sluijs, P., van Meer, G. Mol. Biol. Cell (2003)
- Molecular and functional characterization of microsomal UDP-glucuronic acid uptake by members of the nucleotide sugar transporter (NST) family. Kobayashi, T., Sleeman, J.E., Coughtrie, M.W., Burchell, B. Biochem. J. (2006)
- Substrate recognition by nucleotide sugar transporters: further characterization of substrate recognition regions by analyses of UDP-galactose/CMP-sialic acid transporter chimeras and biochemical analysis of the substrate specificity of parental and chimeric transporters. Aoki, K., Ishida, N., Kawakita, M. J. Biol. Chem. (2003)
- Genetic defects at the UGT1 locus associated with Crigler-Najjar type I disease, including a prenatal diagnosis. Ciotti, M., Obaray, R., Martín, M.G., Owens, I.S. Am. J. Med. Genet. (1997)
- The human gene CGT encoding the UDP-galactose ceramide galactosyl transferase (cerebroside synthase): cloning, characterization, and assignment to human chromosome 4, band q26. Bosio, A., Binczek, E., Le Beau, M.M., Fernald, A.A., Stoffel, W. Genomics (1996)
- UDP-galactose:ceramide galactosyltransferase is a class I integral membrane protein of the endoplasmic reticulum. Sprong, H., Kruithof, B., Leijendekker, R., Slot, J.W., van Meer, G., van der Sluijs, P. J. Biol. Chem. (1998)