Gene Review:
UGT2B4 - UDP glucuronosyltransferase 2 family,...
Homo sapiens
Synonyms:
HLUG25, Hyodeoxycholic acid-specific UDPGT, UDP-glucuronosyltransferase 2B4, UDPGT 2B4, UDPGT2B4, ...
Collier,
Ganley,
Tingle,
Blumenstein,
Marvin,
Paxton,
Mitchell,
Keelan,
Radominska-Pandya,
Little,
Pandya,
Tephly,
King,
Barone,
Raufman,
Mackenzie,
Little,
Radominska-Pandya,
Strassburg,
Strassburg,
Kneip,
Barut,
Tukey,
Rodeck,
Manns,
- Peroxisome proliferator-activated receptor alpha induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzyme. Barbier, O., Duran-Sandoval, D., Pineda-Torra, I., Kosykh, V., Fruchart, J.C., Staels, B. J. Biol. Chem. (2003)
- FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity. Barbier, O., Torra, I.P., Sirvent, A., Claudel, T., Blanquart, C., Duran-Sandoval, D., Kuipers, F., Kosykh, V., Fruchart, J.C., Staels, B. Gastroenterology (2003)
- Glucuronidation of hyodeoxycholic acid in human liver. Evidence for a selective role of UDP-glucuronosyltransferase 2B4. Pillot, T., Ouzzine, M., Fournel-Gigleux, S., Lafaurie, C., Radominska, A., Burchell, B., Siest, G., Magdalou, J. J. Biol. Chem. (1993)
- Immunochemical analysis of uridine diphosphate-glucuronosyltransferase in four patients with the Crigler-Najjar syndrome type I. van Es, H.H., Goldhoorn, B.G., Paul-Abrahamse, M., Elferink, R.P., Jansen, P.L. J. Clin. Invest. (1990)
- Role of hydrophilic bile acids and of sterols on cholelithiasis in the hamster. Singhal, A.K., Cohen, B.I., Finver-Sadowsky, J., McSherry, C.K., Mosbach, E.H. J. Lipid Res. (1984)
- Gene therapy with bilirubin-UDP-glucuronosyltransferase in the Gunn rat model of Crigler-Najjar syndrome type 1. Li, Q., Murphree, S.S., Willer, S.S., Bolli, R., French, B.A. Hum. Gene Ther. (1998)
- Hyodeoxycholic acid: a new approach to gallstone prevention. McSherry, C.K., Mosbach, E.H., Cohen, B.I., Une, M., Stenger, R.J., Singhal, A.K. Am. J. Surg. (1985)
- Characterization and substrate specificity of UGT2B4 (E458): a UDP-glucuronosyltransferase encoded by a polymorphic gene. Lévesque, E., Beaulieu, M., Hum, D.W., Bélanger, A. Pharmacogenetics (1999)
- Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13. Monaghan, G., Clarke, D.J., Povey, S., See, C.G., Boxer, M., Burchell, B. Genomics (1994)
- Prominent but reverse stereoselectivity in propranolol glucuronidation by human UDP-glucuronosyltransferases 1A9 and 1A10. Sten, T., Qvisen, S., Uutela, P., Luukkanen, L., Kostiainen, R., Finel, M. Drug Metab. Dispos. (2006)
- Single nucleotide polymorphisms and haplotype frequencies of UGT2B4 and UGT2B7 in a Japanese population. Saeki, M., Saito, Y., Jinno, H., Tanaka-Kagawa, T., Ohno, A., Ozawa, S., Ueno, K., Kamakura, S., Kamatani, N., Komamura, K., Kitakaze, M., Sawada, J. Drug Metab. Dispos. (2004)
- UDP-glucuronosyltransferase activity, expression and cellular localization in human placenta at term. Collier, A.C., Ganley, N.A., Tingle, M.D., Blumenstein, M., Marvin, K.W., Paxton, J.W., Mitchell, M.D., Keelan, J.A. Biochem. Pharmacol. (2002)
- UDPGT cDNA expression and UDPGT1 in human liver. Sheen, Y.Y., Owens, I.S., Kim, S.S., Kim, J.E. The Journal of toxicological sciences. (1998)
- Reduction and glucuronidation of naftazone by human and rat liver microsomes. Herber, R., Hercelin, B., Van Cantfort, J., De Graeve, J., Fournel-Gigleux, S., Taguchi, T., Magdalou, J. Drug Metab. Dispos. (1995)
- Stable expression of two human UDP-glucuronosyltransferase cDNAs in V79 cell cultures. Fournel-Gigleux, S., Sutherland, L., Sabolovic, N., Burchell, B., Siest, G. Mol. Pharmacol. (1991)
- Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members. Turgeon, D., Carrier, J.S., Lévesque, E., Hum, D.W., Bélanger, A. Endocrinology (2001)
- UDP-glucuronosyltransferases in human intestinal mucosa. Radominska-Pandya, A., Little, J.M., Pandya, J.T., Tephly, T.R., King, C.D., Barone, G.W., Raufman, J.P. Biochim. Biophys. Acta (1998)
- Glucosidation of hyodeoxycholic acid by UDP-glucuronosyltransferase 2B7. Mackenzie, P., Little, J.M., Radominska-Pandya, A. Biochem. Pharmacol. (2003)
- Developmental aspects of human hepatic drug glucuronidation in young children and adults. Strassburg, C.P., Strassburg, A., Kneip, S., Barut, A., Tukey, R.H., Rodeck, B., Manns, M.P. Gut (2002)
- UDP glucuronosyltransferase mRNA levels in human liver disease. Congiu, M., Mashford, M.L., Slavin, J.L., Desmond, P.V. Drug Metab. Dispos. (2002)
- Expression of a human liver cDNA encoding a UDP-glucuronosyltransferase catalysing the glucuronidation of hyodeoxycholic acid in cell culture. Fournel-Gigleux, S., Jackson, M.R., Wooster, R., Burchell, B. FEBS Lett. (1989)
- Evidence that tacrolimus augments the bioavailability of mycophenolate mofetil through the inhibition of mycophenolic acid glucuronidation. Zucker, K., Tsaroucha, A., Olson, L., Esquenazi, V., Tzakis, A., Miller, J. Therapeutic drug monitoring. (1999)
- Isolation and characterization of hyodeoxycholic-acid: UDP-glucuronosyltransferase from human liver. Matern, H., Lappas, N., Matern, S. Eur. J. Biochem. (1991)