Gene Review:
VAV2 - vav 2 guanine nucleotide exchange factor
Homo sapiens
Synonyms:
Guanine nucleotide exchange factor VAV2, VAV-2
- Activation of Vav/Rho GTPase signaling by CXCL12 controls membrane-type matrix metalloproteinase-dependent melanoma cell invasion. Bartolomé, R.A., Molina-Ortiz, I., Samaniego, R., Sánchez-Mateos, P., Bustelo, X.R., Teixidó, J. Cancer Res. (2006)
- The P2Y2 nucleotide receptor interacts with alphav integrins to activate Go and induce cell migration. Bagchi, S., Liao, Z., Gonzalez, F.A., Chorna, N.E., Seye, C.I., Weisman, G.A., Erb, L. J. Biol. Chem. (2005)
- VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin. Gavard, J., Gutkind, J.S. Nat. Cell Biol. (2006)
- Vav3 is regulated during the cell cycle and effects cell division. Fujikawa, K., Inoue, Y., Sakai, M., Koyama, Y., Nishi, S., Funada, R., Alt, F.W., Swat, W. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Critical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformation. Booden, M.A., Campbell, S.L., Der, C.J. Mol. Cell. Biol. (2002)
- Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, but neither is required for regulation of phospholipase C. Pearce, A.C., Wilde, J.I., Doody, G.M., Best, D., Inoue, O., Vigorito, E., Tybulewicz, V.L., Turner, M., Watson, S.P. Blood (2002)
- Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins. Liu, B.P., Burridge, K. Mol. Cell. Biol. (2000)
- Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth. Bourguignon, L.Y., Zhu, H., Zhou, B., Diedrich, F., Singleton, P.A., Hung, M.C. J. Biol. Chem. (2001)
- Vav2 activates c-fos serum response element and CD69 expression but negatively regulates nuclear factor of activated T cells and interleukin-2 gene activation in T lymphocyte. Tartare-Deckert, S., Monthouel, M.N., Charvet, C., Foucault, I., Van Obberghen, E., Bernard, A., Altman, A., Deckert, M. J. Biol. Chem. (2001)
- Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1. Henske, E.P., Short, M.P., Jozwiak, S., Bovey, C.M., Ramlakhan, S., Haines, J.L., Kwiatkowski, D.J. Ann. Hum. Genet. (1995)
- Vav proteins, masters of the world of cytoskeleton organization. Hornstein, I., Alcover, A., Katzav, S. Cell. Signal. (2004)
- Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor. Miller, S.L., DeMaria, J.E., Freier, D.O., Riegel, A.M., Clevenger, C.V. Mol. Endocrinol. (2005)
- PTP-PEST Couples Membrane Protrusion and Tail Retraction via VAV2 and p190RhoGAP. Sastry, S.K., Rajfur, Z., Liu, B.P., Cote, J.F., Tremblay, M.L., Burridge, K. J. Biol. Chem. (2006)
- Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac. Tamás, P., Solti, Z., Bauer, P., Illés, A., Sipeki, S., Bauer, A., Faragó, A., Downward, J., Buday, L. J. Biol. Chem. (2003)
- Membrane-targeting is critical for the phosphorylation of Vav2 by activated EGF receptor. Tamás, P., Solti, Z., Buday, L. Cell. Signal. (2001)
- Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors. Trenkle, T., McClelland, M., Adlkofer, K., Welsh, J. Gene (2000)