Disease relevance of Errfi1

• Our results provide insight into the mechanism of osteoarthritis by showing that loss of Mig-6 leads to early onset of this disease, implying that this gene or its pathway is important in normal joint maintenance [1].
• Targeted disruption of Mig-6 in the mouse genome leads to early onset degenerative joint disease [1].
• Moreover, germline disruption of Mig-6 in mice leads to the development of animals with epithelial hyperplasia, adenoma, and adenocarcinoma in organs like the lung, gallbladder, and bile duct [2].
• Gene 33/RALT is induced by hypoxia in cardiomyocytes, where it promotes cell death by suppressing phosphatidylinositol 3-kinase and extracellular signal-regulated kinase survival signaling [3].

High impact information on Errfi1

• Carcinogen-induced tumors displayed by Errfi1(-/-) mice were highly sensitive to gefitinib [4].

Analytical, diagnostic and therapeutic context of Errfi1

• Because of the striking similarity of osteoarthritis in humans and mice, the Mig-6 mutant mouse should provide a useful animal model for studying the mechanism of this disease and for testing drugs or therapies for treating osteoarthritis [1].

References