Gene Review:
Pik3cb - phosphatidylinositol 3-kinase, catalytic,...
Mus musculus
Synonyms:
1110001J02Rik, AI447572, PI3-kinase subunit beta, PI3K-beta, PI3Kbeta, ...
Webb,
Vigorito,
Wymann,
Hirsch,
Turner,
Jackson,
Schoenwaelder,
Goncalves,
Nesbitt,
Yap,
Wright,
Kenche,
Anderson,
Dopheide,
Yuan,
Sturgeon,
Prabaharan,
Thompson,
Smith,
Shepherd,
Daniele,
Kulkarni,
Abbott,
Saylik,
Jones,
Lu,
Giuliano,
Hughan,
Angus,
Robertson,
Salem,
Jackson,
Schoenwaelder,
Vogt,
Bader,
Kang,
Zhao,
Liu,
Wang,
Shin,
Loda,
Roberts,
Asano,
Kanda,
Katagiri,
Nawano,
Ogihara,
Inukai,
Anai,
Fukushima,
Yazaki,
Kikuchi,
Hooshmand-Rad,
Heldin,
Oka,
Funaki,
- Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice. Brachmann, S.M., Ueki, K., Engelman, J.A., Kahn, R.C., Cantley, L.C. Mol. Cell. Biol. (2005)
- A specific function for phosphatidylinositol 3-kinase alpha (p85alpha-p110alpha) in cell survival and for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in de novo DNA synthesis of human colon carcinoma cells. Bénistant, C., Chapuis, H., Roche, S. Oncogene (2000)
- Type I phosphoinositide 3-kinases: potential antithrombotic targets? Jackson, S.F., Schoenwaelder, S.M. Cell. Mol. Life Sci. (2006)
- Anaphylactic shock depends on PI3K and eNOS-derived NO. Cauwels, A., Janssen, B., Buys, E., Sips, P., Brouckaert, P. J. Clin. Invest. (2006)
- The phosphoinositide 3-kinase/Akt pathway: a new target in human renal cell carcinoma therapy. Sourbier, C., Lindner, V., Lang, H., Agouni, A., Schordan, E., Danilin, S., Rothhut, S., Jacqmin, D., Helwig, J.J., Massfelder, T. Cancer Res. (2006)
- A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Knight, Z.A., Gonzalez, B., Feldman, M.E., Zunder, E.R., Goldenberg, D.D., Williams, O., Loewith, R., Stokoe, D., Balla, A., Toth, B., Balla, T., Weiss, W.A., Williams, R.L., Shokat, K.M. Cell (2006)
- Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Terauchi, Y., Tsuji, Y., Satoh, S., Minoura, H., Murakami, K., Okuno, A., Inukai, K., Asano, T., Kaburagi, Y., Ueki, K., Nakajima, H., Hanafusa, T., Matsuzawa, Y., Sekihara, H., Yin, Y., Barrett, J.C., Oda, H., Ishikawa, T., Akanuma, Y., Komuro, I., Suzuki, M., Yamamura, K., Kodama, T., Suzuki, H., Yamamura, K., Kodama, T., Suzuki, H., Koyasu, S., Aizawa, S., Tobe, K., Fukui, Y., Yazaki, Y., Kadowaki, T. Nat. Genet. (1999)
- PI 3-kinase p110beta: a new target for antithrombotic therapy. Jackson, S.P., Schoenwaelder, S.M., Goncalves, I., Nesbitt, W.S., Yap, C.L., Wright, C.E., Kenche, V., Anderson, K.E., Dopheide, S.M., Yuan, Y., Sturgeon, S.A., Prabaharan, H., Thompson, P.E., Smith, G.D., Shepherd, P.R., Daniele, N., Kulkarni, S., Abbott, B., Saylik, D., Jones, C., Lu, L., Giuliano, S., Hughan, S.C., Angus, J.A., Robertson, A.D., Salem, H.H. Nat. Med. (2005)
- Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice. Fukao, T., Yamada, T., Tanabe, M., Terauchi, Y., Ota, T., Takayama, T., Asano, T., Takeuchi, T., Kadowaki, T., Hata Ji, J., Koyasu, S. Nat. Immunol. (2002)
- Blockade of inflammation and airway hyperresponsiveness in immune-sensitized mice by dominant-negative phosphoinositide 3-kinase-TAT. Myou, S., Leff, A.R., Myo, S., Boetticher, E., Tong, J., Meliton, A.Y., Liu, J., Munoz, N.M., Zhu, X. J. Exp. Med. (2003)
- Phosphoinositide 3-kinase in nitric oxide synthesis in macrophage: critical dimerization of inducible nitric-oxide synthase. Sakai, K., Suzuki, H., Oda, H., Akaike, T., Azuma, Y., Murakami, T., Sugi, K., Ito, T., Ichinose, H., Koyasu, S., Shirai, M. J. Biol. Chem. (2006)
- Significance of Akt phosphorylation on tumor growth and vascular endothelial growth factor expression in human gastric carcinoma. Kobayashi, I., Semba, S., Matsuda, Y., Kuroda, Y., Yokozaki, H. Pathobiology (2006)
- Intracellular segregation of phosphatidylinositol-3,4,5-trisphosphate by insulin-dependent actin remodeling in L6 skeletal muscle cells. Patel, N., Rudich, A., Khayat, Z.A., Garg, R., Klip, A. Mol. Cell. Biol. (2003)
- Class I phosphoinositide 3-kinase p110beta is required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by macrophages. Leverrier, Y., Okkenhaug, K., Sawyer, C., Bilancio, A., Vanhaesebroeck, B., Ridley, A.J. J. Biol. Chem. (2003)
- The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells. Zhao, J.J., Liu, Z., Wang, L., Shin, E., Loda, M.F., Roberts, T.M. Proc. Natl. Acad. Sci. U.S.A. (2005)
- P110delta, a novel phosphoinositide 3-kinase in leukocytes. Vanhaesebroeck, B., Welham, M.J., Kotani, K., Stein, R., Warne, P.H., Zvelebil, M.J., Higashi, K., Volinia, S., Downward, J., Waterfield, M.D. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Cutting edge: T cell development requires the combined activities of the p110gamma and p110delta catalytic isoforms of phosphatidylinositol 3-kinase. Webb, L.M., Vigorito, E., Wymann, M.P., Hirsch, E., Turner, M. J. Immunol. (2005)
- Actin filaments participate in the relocalization of phosphatidylinositol3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes. Wang, Q., Bilan, P.J., Tsakiridis, T., Hinek, A., Klip, A. Biochem. J. (1998)
- Oncogenic Kit signaling and therapeutic intervention in a mouse model of gastrointestinal stromal tumor. Rossi, F., Ehlers, I., Agosti, V., Socci, N.D., Viale, A., Sommer, G., Yozgat, Y., Manova, K., Antonescu, C.R., Besmer, P. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Signaling in lipopolysaccharide-induced stabilization of formyl Peptide receptor 1 mRNA in mouse peritoneal macrophages. Mandal, P., Hamilton, T. J. Immunol. (2007)
- A novel role for phosphatidylinositol 3-kinase beta in signaling from G protein-coupled receptors to Akt. Murga, C., Fukuhara, S., Gutkind, J.S. J. Biol. Chem. (2000)
- p110beta is up-regulated during differentiation of 3T3-L1 cells and contributes to the highly insulin-responsive glucose transport activity. Asano, T., Kanda, A., Katagiri, H., Nawano, M., Ogihara, T., Inukai, K., Anai, M., Fukushima, Y., Yazaki, Y., Kikuchi, M., Hooshmand-Rad, R., Heldin, C.H., Oka, Y., Funaki, M. J. Biol. Chem. (2000)
- A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid. Yart, A., Roche, S., Wetzker, R., Laffargue, M., Tonks, N., Mayeux, P., Chap, H., Raynal, P. J. Biol. Chem. (2002)
- p85/p110-type phosphatidylinositol kinase phosphorylates not only the D-3, but also the D-4 position of the inositol ring. Funaki, M., Katagiri, H., Kanda, A., Anai, M., Nawano, M., Ogihara, T., Inukai, K., Fukushima, Y., Ono, H., Yazaki, Y., Kikuchi, M., Oka, Y., Asano, T. J. Biol. Chem. (1999)
- Phosphatidylinositide 3-kinase localizes to cytoplasmic lipid bodies in human polymorphonuclear leukocytes and other myeloid-derived cells. Yu, W., Cassara, J., Weller, P.F. Blood (2000)
- Region-specific mRNA expression of phosphatidylinositol 3-kinase regulatory isoforms in the central nervous system of C57BL/6J mice. Hörsch, D., Kahn, C.R. J. Comp. Neurol. (1999)
- A function for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in fibroblasts during mitogenesis: requirement for insulin- and lysophosphatidic acid-mediated signal transduction. Roche, S., Downward, J., Raynal, P., Courtneidge, S.A. Mol. Cell. Biol. (1998)
- An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model. Duan, W., Aguinaldo Datiles, A.M., Leung, B.P., Vlahos, C.J., Wong, W.S. Int. Immunopharmacol. (2005)
- PI 3-kinases: hidden potentials revealed. Vogt, P.K., Bader, A.G., Kang, S. Cell Cycle (2006)