Gene Review:
XRCC2 - X-ray repair complementing defective...
Homo sapiens
Synonyms:
DNA repair protein XRCC2, X-ray repair cross-complementing protein 2
Hunter,
Urbin,
Hunter,
Tsomondo,
Colditz,
Liu,
Sarasin,
Hinz,
Thompson,
Popanda,
Bouchardy,
Rodríguez-López,
Schild,
Zhang,
Benítez,
Tuimala,
Sautter-Bihl,
Haase,
Caldés,
Collins,
Samson,
Wenz,
Tebbs,
Sale,
Ambrosone,
Takata,
Kropp,
Liu,
Schild,
Dayer,
Benhamou,
De La Hoya,
Thelen,
De Vivo,
Schild,
Lim,
Osorio,
Chang-Claude,
Neuberger,
von Fournier,
Hirvonen,
Helmbold,
Collins,
Barroso,
Chen,
Hankinson,
Lio,
Calandrini,
Takeda,
Schmezer,
Han,
Wiese,
Thompson,
Han,
Sánchez-Pulido,
Nham,
Tan,
- Evidence for simultaneous protein interactions between human Rad51 paralogs. Schild, D., Lio, Y.C., Collins, D.W., Tsomondo, T., Chen, D.J. J. Biol. Chem. (2000)
- Variants in DNA double-strand break repair genes and breast cancer susceptibility. Kuschel, B., Auranen, A., McBride, S., Novik, K.L., Antoniou, A., Lipscombe, J.M., Day, N.E., Easton, D.F., Ponder, B.A., Pharoah, P.D., Dunning, A. Hum. Mol. Genet. (2002)
- A naturally occurring genetic variant of human XRCC2 (R188H) confers increased resistance to cisplatin-induced DNA damage. Danoy, P., Sonoda, E., Lathrop, M., Takeda, S., Matsuda, F. Biochem. Biophys. Res. Commun. (2007)
- Polymorphisms in DNA double-strand break repair genes and skin cancer risk. Han, J., Colditz, G.A., Samson, L.D., Hunter, D.J. Cancer Res. (2004)
- DNA repair gene XRCC2 and XRCC3 polymorphisms and susceptibility to cancers of the upper aerodigestive tract. Benhamou, S., Tuimala, J., Bouchardy, C., Dayer, P., Sarasin, A., Hirvonen, A. Int. J. Cancer (2004)
- XRCC2 and XRCC3 gene polymorphism and risk of pancreatic cancer. Jiao, L., Hassan, M.M., Bondy, M.L., Wolff, R.A., Evans, D.B., Abbruzzese, J.L., Li, D. Am. J. Gastroenterol. (2008)
- Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation. Sale, J.E., Calandrini, D.M., Takata, M., Takeda, S., Neuberger, M.S. Nature (2001)
- Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination. Johnson, R.D., Liu, N., Jasin, M. Nature (1999)
- Interaction between genetic variations in DNA repair genes and plasma folate on breast cancer risk. Han, J., Hankinson, S.E., Zhang, S.M., De Vivo, I., Hunter, D.J. Cancer Epidemiol. Biomarkers Prev. (2004)
- XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages. Liu, N., Lamerdin, J.E., Tebbs, R.S., Schild, D., Tucker, J.D., Shen, M.R., Brookman, K.W., Siciliano, M.J., Walter, C.A., Fan, W., Narayana, L.S., Zhou, Z.Q., Adamson, A.W., Sorensen, K.J., Chen, D.J., Jones, N.J., Thompson, L.H. Mol. Cell (1998)
- Defining the roles of nucleotide excision repair and recombination in the repair of DNA interstrand cross-links in mammalian cells. De Silva, I.U., McHugh, P.J., Clingen, P.H., Hartley, J.A. Mol. Cell. Biol. (2000)
- The RAD51 family member, RAD51L3, is a DNA-stimulated ATPase that forms a complex with XRCC2. Braybrooke, J.P., Spink, K.G., Thacker, J., Hickson, I.D. J. Biol. Chem. (2000)
- Homologous recombination as a potential target for caffeine radiosensitization in mammalian cells: reduced caffeine radiosensitization in XRCC2 and XRCC3 mutants. Asaad, N.A., Zeng, Z.C., Guan, J., Thacker, J., Iliakis, G. Oncogene (2000)
- XRCC3 ATPase activity is required for normal XRCC3-Rad51C complex dynamics and homologous recombination. Yamada, N.A., Hinz, J.M., Kopf, V.L., Segalle, K.D., Thompson, L.H. J. Biol. Chem. (2004)
- Genetic interactions between RAD51 and its paralogues for centrosome fragmentation and ploidy control, independently of the sensitivity to genotoxic stresses. Daboussi, F., Thacker, J., Lopez, B.S. Oncogene (2005)
- The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family. Cartwright, R., Tambini, C.E., Simpson, P.J., Thacker, J. Nucleic Acids Res. (1998)
- A tumour-derived mutant allele of XRCC2 preferentially suppresses homologous recombination at DNA replication forks. Mohindra, A., Bolderson, E., Stone, J., Wells, M., Helleday, T., Meuth, M. Hum. Mol. Genet. (2004)
- Differential roles of XRCC2 in homologous recombinational repair of stalled replication forks. Liu, N., Lim, C.S. J. Cell. Biochem. (2005)
- hXRCC2 enhances ADP/ATP processing and strand exchange by hRAD51. Shim, K.S., Schmutte, C., Tombline, G., Heinen, C.D., Fishel, R. J. Biol. Chem. (2004)
- Disparate requirements for the Walker A and B ATPase motifs of human RAD51D in homologous recombination. Wiese, C., Hinz, J.M., Tebbs, R.S., Nham, P.B., Urbin, S.S., Collins, D.W., Thompson, L.H., Schild, D. Nucleic Acids Res. (2006)
- Sws1 is a conserved regulator of homologous recombination in eukaryotic cells. Martín, V., Chahwan, C., Gao, H., Blais, V., Wohlschlegel, J., Yates, J.R., McGowan, C.H., Russell, P. EMBO J. (2006)
- Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells. Wiese, C., Collins, D.W., Albala, J.S., Thompson, L.H., Kronenberg, A., Schild, D. Nucleic Acids Res. (2002)
- No mutations in the XRCC2 gene in BRCA1/2-negative high-risk breast cancer families. Rodríguez-López, R., Osorio, A., Sánchez-Pulido, L., De La Hoya, M., Barroso, A., Caldés, T., Benítez, J. Int. J. Cancer (2003)
- Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells. Liu, N., Schild, D., Thelen, M.P., Thompson, L.H. Nucleic Acids Res. (2002)
- A potential role for the XRCC2 R188H polymorphic site in DNA-damage repair and breast cancer. Rafii, S., O'Regan, P., Xinarianos, G., Azmy, I., Stephenson, T., Reed, M., Meuth, M., Thacker, J., Cox, A. Hum. Mol. Genet. (2002)
- Genetic polymorphisms in the DNA double-strand break repair genes XRCC3, XRCC2, and NBS1 are not associated with acute side effects of radiotherapy in breast cancer patients. Popanda, O., Tan, X.L., Ambrosone, C.B., Kropp, S., Helmbold, I., von Fournier, D., Haase, W., Sautter-Bihl, M.L., Wenz, F., Schmezer, P., Chang-Claude, J. Cancer Epidemiol. Biomarkers Prev. (2006)