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ZNF10  -  zinc finger protein 10

Homo sapiens

Synonyms: KOX1, Zinc finger protein 10, Zinc finger protein KOX1
 
 
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Disease relevance of ZNF10

 

High impact information on ZNF10

  • Further, the genomic clones were cross-hybridized with a set of 30 zinc finger-encoding cDNAs (Kox1-Kox30) isolated from a human T-cell cDNA library [2].
  • Using purified components, a combination of biochemical and biophysical analyses has revealed that the KRAB domain from the KOX1 protein is predominantly a monomer and that the KAP-1 protein is predominantly a trimer in solution [3].
  • The KRAB domain from ZNF136, containing only subdomain A, is a considerable weaker suppression domain; however, when fused to the heterologous KRAB B subdomain of ZNF10 (KOX1) the two subdomains from a KRAB domain which induces repression as potently as previously reported KRAB domains [4].
  • The KRAB domain of human Kox1, a member of the KRAB C2H2 zinc finger family, confers strong transcriptional repressor activities even to remote promoter positions [5].
  • Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a Krüppel-type zinc finger factor [6].
 

Anatomical context of ZNF10

  • Analysis of cKox1 demonstrated that Kox1 is a single-copy gene that is expressed in a variety of hematopoietic and nonhaematopoietic cell lines. cKox1 encodes 11 zinc fingers that were shown to bind zinc when expressed as a beta-gal-Kox1 fusion protein [7].
 

Physical interactions of ZNF10

  • Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1 [8].

References

  1. Repression of the human immunodeficiency virus type 1 promoter by the human KRAB domain results in inhibition of virus production. Herchenröder, O., Hahne, J.C., Meyer, W.K., Thiesen, H.J., Schneider, J. Biochim. Biophys. Acta (1999) [Pubmed]
  2. Characterization and mapping of human genes encoding zinc finger proteins. Bray, P., Lichter, P., Thiesen, H.J., Ward, D.C., Dawid, I.B. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  3. Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain. Peng, H., Begg, G.E., Harper, S.L., Friedman, J.R., Speicher, D.W., Rauscher, F.J. J. Biol. Chem. (2000) [Pubmed]
  4. Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins. Vissing, H., Meyer, W.K., Aagaard, L., Tommerup, N., Thiesen, H.J. FEBS Lett. (1995) [Pubmed]
  5. Transcriptional repression mediated by the KRAB domain of the human C2H2 zinc finger protein Kox1/ZNF10 does not require histone deacetylation. Lorenz, P., Koczan, D., Thiesen, H.J. Biol. Chem. (2001) [Pubmed]
  6. Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a Krüppel-type zinc finger factor. Moosmann, P., Georgiev, O., Thiesen, H.J., Hagmann, M., Schaffner, W. Biol. Chem. (1997) [Pubmed]
  7. Multiple genes encoding zinc finger domains are expressed in human T cells. Thiesen, H.J. New Biol. (1990) [Pubmed]
  8. Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1. Moosmann, P., Georgiev, O., Le Douarin, B., Bourquin, J.P., Schaffner, W. Nucleic Acids Res. (1996) [Pubmed]
 
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