Gene Review:
CA2 - carbonic anhydrase II
Homo sapiens
Synonyms:
CA-II, CAC, CAII, Car2, Carbonate dehydratase II, ...
Ho,
Bondar,
Purohit,
Tatishchev,
Abuladze,
Fedotoff,
Potter,
Gross,
Thiyagarajan,
Holger M. Becker,
Joachim W. Deitmer,
Sutcliffe,
Ngyuen,
Lee,
Fishkind,
Acharya,
Newman,
Reed,
Woo,
Christianson,
Rosenblatt,
Alper,
Kurtz,
Cox,
Pushkin,
Azimov,
Lloyd,
- Carbonic anhydrase isozymes IV and II in urinary membranes from carbonic anhydrase II-deficient patients. Sato, S., Zhu, X.L., Sly, W.S. Proc. Natl. Acad. Sci. U.S.A. (1990)
- Carbonic anhydrase II deficiency: diagnosis and carrier detection using differential enzyme inhibition and inactivation. Sundaram, V., Rumbolo, P., Grubb, J., Strisciuglio, P., Sly, W.S. Am. J. Hum. Genet. (1986)
- Catalysis and inhibition of human carbonic anhydrase IV. Baird, T.T., Waheed, A., Okuyama, T., Sly, W.S., Fierke, C.A. Biochemistry (1997)
- Carbonic anhydrase II in the cerebrospinal fluid: its value as a disease marker. Parkkila, A.K., Parkkila, S., Reunanen, M., Niemelä, O., Tuisku, S., Rautakorpi, I., Rajaniemi, H. Eur. J. Clin. Invest. (1997)
- Evaluation of carbonic anhydrase isozymes in disorders involving osteopetrosis and/or renal tubular acidosis. Sly, W.S., Sato, S., Zhu, X.L. Clin. Biochem. (1991)
- Carbonic anhydrase II in the endothelium of glial tumors: a potential target for therapy. Haapasalo, J., Nordfors, K., Järvelä, S., Bragge, H., Rantala, I., Parkkila, A.K., Haapasalo, H., Parkkila, S. Neuro-oncology (2007)
- Quantitative study of neurofibrillary tangles in subdivisions of the hippocampus. CA2 as a special area in normal aging and senile dementia of the Alzheimer type. Mizutani, T., Shimada, H. Acta Pathol. Jpn. (1991)
- Differential hippocampal expression of glutamic acid decarboxylase 65 and 67 messenger RNA in bipolar disorder and schizophrenia. Heckers, S., Stone, D., Walsh, J., Shick, J., Koul, P., Benes, F.M. Arch. Gen. Psychiatry (2002)
- Hippocampal connectivity and Alzheimer's dementia: effects of synapse loss and tangle frequency in a two-component model. Samuel, W., Masliah, E., Hill, L.R., Butters, N., Terry, R. Neurology (1994)
- Bilateral lesions of CA1 and CA2 fields of the hippocampus are sufficient to cause a severe amnesic syndrome in humans. Kartsounis, L.D., Rudge, P., Stevens, J.M. J. Neurol. Neurosurg. Psychiatr. (1995)
- Genetic diseases of acid-base transporters. Alper, S.L. Annu. Rev. Physiol. (2002)
- Catalysis by metal-activated hydroxide in zinc and manganese metalloenzymes. Christianson, D.W., Cox, J.D. Annu. Rev. Biochem. (1999)
- Carbonic anhydrase II deficiency in 12 families with the autosomal recessive syndrome of osteopetrosis with renal tubular acidosis and cerebral calcification. Sly, W.S., Whyte, M.P., Sundaram, V., Tashian, R.E., Hewett-Emmett, D., Guibaud, P., Vainsel, M., Baluarte, H.J., Gruskin, A., Al-Mosawi, M. N. Engl. J. Med. (1985)
- The functional and physical relationship between the DRA bicarbonate transporter and carbonic anhydrase II. Sterling, D., Brown, N.J., Supuran, C.T., Casey, J.R. Am. J. Physiol., Cell Physiol. (2002)
- Neuroprotective properties of the novel antiepileptic lamotrigine in a gerbil model of global cerebral ischemia. Wiard, R.P., Dickerson, M.C., Beek, O., Norton, R., Cooper, B.R. Stroke (1995)
- Ischemia-induced neuronal cell loss is associated with loss of atypical angiotensin type-1 receptor expression in the gerbil hippocampal formation. Häuser, W., Jöhren, O., de Oliveira, A.M., Shibata, S., Saavedra, J.M. Brain Res. (1999)
- Effects of memantine on synaptic transmission in the hippocampus in vitro. Dimpfel, W. Arzneimittel-Forschung. (1995)
- Inhibition by anions of human red cell carbonic anhydrase B: physiological and biochemical implications. Maren, T.H., Rayburn, C.S., Liddell, N.E. Science (1976)
- The gene for human carbonic anhydrase II (CA2) is located at chromosome 8q22. Nakai, H., Byers, M.G., Venta, P.J., Tashian, R.E., Shows, T.B. Cytogenet. Cell Genet. (1987)
- Proficiency in interscalene anesthesia-how many blocks are necessary? Rosenblatt, M.A., Fishkind, D. Journal of clinical anesthesia. (2003)
- A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers. Sterling, D., Reithmeier, R.A., Casey, J.R. J. Biol. Chem. (2001)
- Amount and distribution of carbonic anhydrases CA I and CA II in the gastrointestinal tract. Lönnerholm, G., Selking, O., Wistrand, P.J. Gastroenterology (1985)
- Membrane-bound carbonic anhydrase IV is expressed in the luminal plasma membrane of the human gallbladder epithelium. Parkkila, S., Parkkila, A.K., Juvonen, T., Waheed, A., Sly, W.S., Saarnio, J., Kaunisto, K., Kellokumpu, S., Rajaniemi, H. Hepatology (1996)
- Carbonic anhydrase inhibitors: anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties. Masereel, B., Rolin, S., Abbate, F., Scozzafava, A., Supuran, C.T. J. Med. Chem. (2002)
- Nonenzymatic proton handling by carbonic anhydrase II during H+-lactate cotransport via monocarboxylate transporter 1. Becker, H.M., Deitmer, J.W. J. Biol. Chem. (2008)
- Structural aspects of isozyme selectivity in the binding of inhibitors to carbonic anhydrases II and IV. Kim, C.Y., Whittington, D.A., Chang, J.S., Liao, J., May, J.A., Christianson, D.W. J. Med. Chem. (2002)
- First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors. Lloyd, M.D., Thiyagarajan, N., Ho, Y.T., Woo, L.W., Sutcliffe, O.B., Purohit, A., Reed, M.J., Acharya, K.R., Potter, B.V. Biochemistry (2005)
- A novel carbonic anhydrase II binding site regulates NHE1 activity. Li, X., Liu, Y., Alvarez, B.V., Casey, J.R., Fliegel, L. Biochemistry (2006)
- Molecular mechanism of kNBC1-carbonic anhydrase II interaction in proximal tubule cells. Pushkin, A., Abuladze, N., Gross, E., Newman, D., Tatishchev, S., Lee, I., Fedotoff, O., Bondar, G., Azimov, R., Ngyuen, M., Kurtz, I. J. Physiol. (Lond.) (2004)
- Direct extracellular interaction between carbonic anhydrase IV and the human NBC1 sodium/bicarbonate co-transporter. Alvarez, B.V., Loiselle, F.B., Supuran, C.T., Schwartz, G.J., Casey, J.R. Biochemistry (2003)
- Carbonic anhydrase II binds to and enhances activity of the Na+/H+ exchanger. Li, X., Alvarez, B., Casey, J.R., Reithmeier, R.A., Fliegel, L. J. Biol. Chem. (2002)
- Preincubation of Candida albicans strains with amphotericin B reduces tumor necrosis factor alpha and interleukin-6 release by human monocytes. Raponi, G., Ghezzi, M.C., Mancini, C., Filadoro, F. Antimicrob. Agents Chemother. (1993)
- Differentiation of pancreatic ductal carcinoma cells associated with selective expression of protein kinase C isoforms. Franz, M.G., Norman, J.G., Fabri, P.J., Gower, W.R. Ann. Surg. Oncol. (1996)
- A widespread silent polymorphism of human carbonic anhydrase III (31 Ile in equilibrium Val): implications for evolutionary genetics. Hewett-Emmett, D., Welty, R.J., Tashian, R.E. Genetics (1983)
- Microtubule-associated protein 2 (MAP2)--a promising approach to diagnosis of forensic types of hypoxia-ischemia. Kühn, J., Meissner, C., Oehmichen, M. Acta Neuropathol. (2005)
- Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds. Puccetti, L., Fasolis, G., Cecchi, A., Winum, J.Y., Gamberi, A., Montero, J.L., Scozzafava, A., Supuran, C.T. Bioorg. Med. Chem. Lett. (2005)
- DNA polymorphism in the 5' flanking region of the human carbonic anhydrase II gene on chromosome 8. Lee, B.L., Venta, P.J., Tashian, R.E. Hum. Genet. (1985)
- Carbonic anhydrase isoenzyme II is located in corticotrophs of the human pituitary gland. Parkkila, A.K., Parkkila, S., Rajaniemi, H. J. Histochem. Cytochem. (1996)
- Gene expression for carbonic anhydrase isoenzymes in human nasal mucosa. Tarun, A.S., Bryant, B., Zhai, W., Solomon, C., Shusterman, D. Chem. Senses (2003)