Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

ZNF133 - zinc finger protein 133

Homo sapiens

Synonyms: ZNF150, Zinc finger protein 133, Zinc finger protein 150, pHZ-13, pHZ-66

Tommerup, N. et al., Ehringer, M.A. et al., Heiskanen, M.A. et al., Vissing, H. et al.

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Disease relevance of ZNF133

ZNF133 was localized to 20p11.2, close to, but probably distinct from, the region deleted in Alagille syndrome [1].
In addition to the detection of the known amplifications, we identified a novel amplified gene, ZNF133, in the neuroblastoma cell line NGP [2].

High impact information on ZNF133

We report the characterization of three novel members of the KRAB-domain containing C2-H2 zinc finger family (ZNF133, 136 and 140) [3].
We have isolated and chromosomally fine-mapped 16 novel genes belonging to the human zinc finger Krüppel family (ZNF131-140, 142, 143, 148, 151, 154, and 155), including 1 of the GLI type (ZNF143) and 3 containing a KRAB (Krüppel-associated box) segment (ZNF133, 136, and 140) [1].
PCR products were obtained for the protein coding region of ZNF133 using human genomic DNA and directly sequenced using automated sequencers [4].

References

Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. Tommerup, N., Vissing, H. Genomics (1995) [Pubmed]
Detection of gene amplification by genomic hybridization to cDNA microarrays. Heiskanen, M.A., Bittner, M.L., Chen, Y., Khan, J., Adler, K.E., Trent, J.M., Meltzer, P.S. Cancer Res. (2000) [Pubmed]
Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins. Vissing, H., Meyer, W.K., Aagaard, L., Tommerup, N., Thiesen, H.J. FEBS Lett. (1995) [Pubmed]
Human alcoholism studies of genes identified through mouse quantitative trait locus analysis. Ehringer, M.A., Thompson, J., Conroy, O., Goldman, D., Smith, T.L., Schuckit, M.A., Sikela, J.M. Addiction biology. (2002) [Pubmed]

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