Gene Review:
CXCR4 - chemokine (C-X-C motif) receptor 4
Homo sapiens
Synonyms:
C-X-C chemokine receptor type 4, CD184, CXC-R4, CXCR-4, D2S201E, ...
Clemetson,
Richardson,
Semenza,
Abbot,
Trkola,
Power,
Snyderman,
Horuk,
Peiper,
Hoxie,
Clemetson,
Yamamoto,
Sinai,
Tsuneyoshi,
Schols,
Price,
De Clercq,
Yokoyama,
Cayabyab,
Tamiya,
Siccardi,
Proudfoot,
Van Damme,
Sironi,
Sata,
Vercelli,
Wyatt,
Lee,
Dettin,
Vaday,
Okuyama,
Farzan,
Keane,
Halks-Miller,
Choe,
Zhu,
Taub,
Jordan,
French,
Nair,
Wells,
Zucker,
Mirzabekov,
Hua,
Baggiolini,
Lusso,
Struyf,
Petraki,
Pauling,
DelVecchio,
Henson,
Gerard,
Moore,
Krishnamachary,
Esté,
Mahajan,
Gorry,
Ali,
Kolson,
Foda,
Pasquato,
Polzer,
Yee,
Lawrence,
Schreiber,
Schwartz,
Gray,
Di Bello,
Hewitt,
Dragic,
Hesselgesser,
Sodroski,
Matsuda,
Tokunaga,
Lin,
Verani,
Zagzag,
Chiriboga,
Melamed,
Gerard,
Whitney,
Oda,
Kolios,
Tanaka,
Iwamoto,
Peehl,
Kolchinsky,
Marjoram,
Thordsen,
Thompson,
Westwick,
- Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry. Farzan, M., Mirzabekov, T., Kolchinsky, P., Wyatt, R., Cayabyab, M., Gerard, N.P., Gerard, C., Sodroski, J., Choe, H. Cell (1999)
- CD4-independent infection by HIV-2 is mediated by fusin/CXCR4. Endres, M.J., Clapham, P.R., Marsh, M., Ahuja, M., Turner, J.D., McKnight, A., Thomas, J.F., Stoebenau-Haggarty, B., Choe, S., Vance, P.J., Wells, T.N., Power, C.A., Sutterwala, S.S., Doms, R.W., Landau, N.R., Hoxie, J.A. Cell (1996)
- HIV coreceptor downregulation as antiviral principle: SDF-1alpha-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication. Amara, A., Gall, S.L., Schwartz, O., Salamero, J., Montes, M., Loetscher, P., Baggiolini, M., Virelizier, J.L., Arenzana-Seisdedos, F. J. Exp. Med. (1997)
- The B-oligomer of pertussis toxin deactivates CC chemokine receptor 5 and blocks entry of M-tropic HIV-1 strains. Alfano, M., Schmidtmayerova, H., Amella, C.A., Pushkarsky, T., Bukrinsky, M. J. Exp. Med. (1999)
- HIV type I envelope determinants for use of the CCR2b, CCR3, STRL33, and APJ coreceptors. Hoffman, T.L., Stephens, E.B., Narayan, O., Doms, R.W. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Immunoimaging of CXCR4 expression in brain tumor xenografts using SPECT/CT. Nimmagadda, S., Pullambhatla, M., Pomper, M.G. J. Nucl. Med. (2009)
- Characterization of chemokine receptors expressed in primitive blood cells during human hematopoietic ontogeny. Rosu-Myles, M., Khandaker, M., Wu, D.M., Keeney, M., Foley, S.R., Howson-Jan, K., Yee, I.C., Fellows, F., Kelvin, D., Bhatia, M. Stem Cells (2000)
- Immunohistochemical analysis of CCR2, CCR3, CCR5, and CXCR4 in the human brain: potential mechanisms for HIV dementia. van der Meer, P., Ulrich, A.M., Gonźalez-Scarano, F., Lavi, E. Exp. Mol. Pathol. (2000)
- Brief Report: CXCR4 or CCR5 Tropism of Human Immunodeficiency Virus Type 1 Isolates Does Not Determine the Immunological Milieu in Patients Responding to Antiretroviral Therapy. Price, P., Keane, N., Gray, L., Lee, S., Gorry, P.R., French, M.A. Viral Immunol. (2006)
- Association of drug abuse with inhibition of HIV-1 immune responses: studies with long-term of HIV-1 non-progressors. Nair, M.P., Mahajan, S., Hewitt, R., Whitney, Z.R., Schwartz, S.A. J. Neuroimmunol. (2004)
- Infection of cells expressing CXCR4 mutants lacking N-glycosylation at the N-terminal extracellular domain is enhanced for R5X4-dualtropic human immunodeficiency virus type-1. Thordsen, I., Polzer, S., Schreiber, M. BMC Infect. Dis. (2002)
- Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease. Hernandez, P.A., Gorlin, R.J., Lukens, J.N., Taniuchi, S., Bohinjec, J., Francois, F., Klotman, M.E., Diaz, G.A. Nat. Genet. (2003)
- A CXCR4/CD4 pseudotype rhabdovirus that selectively infects HIV-1 envelope protein-expressing cells. Mebatsion, T., Finke, S., Weiland, F., Conzelmann, K.K. Cell (1997)
- Construction of a novel virus that targets HIV-1-infected cells and controls HIV-1 infection. Schnell, M.J., Johnson, J.E., Buonocore, L., Rose, J.K. Cell (1997)
- A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Doranz, B.J., Rucker, J., Yi, Y., Smyth, R.J., Samson, M., Peiper, S.C., Parmentier, M., Collman, R.G., Doms, R.W. Cell (1996)
- CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons. Hesselgesser, J., Halks-Miller, M., DelVecchio, V., Peiper, S.C., Hoxie, J., Kolson, D.L., Taub, D., Horuk, R. Curr. Biol. (1997)
- Expression of functional chemokine receptors CXCR3 and CXCR4 on human melanoma cells. Robledo, M.M., Bartolome, R.A., Longo, N., Rodríguez-Frade, J.M., Mellado, M., Longo, I., van Muijen, G.N., Sánchez-Mateos, P., Teixidó, J. J. Biol. Chem. (2001)
- Inhibition of CXCR4-tropic HIV-1 infection by lipopolysaccharide: evidence of different mechanisms in macrophages and T lymphocytes. Verani, A., Sironi, F., Siccardi, A.G., Lusso, P., Vercelli, D. J. Immunol. (2002)
- Interleukin-8-mediated heterologous receptor internalization provides resistance to HIV-1 infectivity. Role of signal strength and receptor desensitization. Richardson, R.M., Tokunaga, K., Marjoram, R., Sata, T., Snyderman, R. J. Biol. Chem. (2003)
- Human melanoma metastases express functional CXCR4. Scala, S., Giuliano, P., Ascierto, P.A., Ieranò, C., Franco, R., Napolitano, M., Ottaiano, A., Lombardi, M.L., Luongo, M., Simeone, E., Castiglia, D., Mauro, F., De Michele, I., Calemma, R., Botti, G., Caracò, C., Nicoletti, G., Satriano, R.A., Castello, G. Clin. Cancer Res. (2006)
- A small molecule CXCR4 inhibitor that blocks T cell line-tropic HIV-1 infection. Murakami, T., Nakajima, T., Koyanagi, Y., Tachibana, K., Fujii, N., Tamamura, H., Yoshida, N., Waki, M., Matsumoto, A., Yoshie, O., Kishimoto, T., Yamamoto, N., Nagasawa, T. J. Exp. Med. (1997)
- Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells. Jordan, N.J., Kolios, G., Abbot, S.E., Sinai, M.A., Thompson, D.A., Petraki, K., Westwick, J. J. Clin. Invest. (1999)
- Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis. Kaul, M., Lipton, S.A. Proc. Natl. Acad. Sci. U.S.A. (1999)
- CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion. Libura, J., Drukala, J., Majka, M., Tomescu, O., Navenot, J.M., Kucia, M., Marquez, L., Peiper, S.C., Barr, F.G., Janowska-Wieczorek, A., Ratajczak, M.Z. Blood (2002)
- Janus kinase 2 is involved in stromal cell-derived factor-1alpha-induced tyrosine phosphorylation of focal adhesion proteins and migration of hematopoietic progenitor cells. Zhang, X.F., Wang, J.F., Matczak, E., Proper, J.A., Groopman, J.E. Blood (2001)
- In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression. Scarlatti, G., Tresoldi, E., Björndal, A., Fredriksson, R., Colognesi, C., Deng, H.K., Malnati, M.S., Plebani, A., Siccardi, A.G., Littman, D.R., Fenyö, E.M., Lusso, P. Nat. Med. (1997)
- Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4. Schols, D., Struyf, S., Van Damme, J., Esté, J.A., Henson, G., De Clercq, E. J. Exp. Med. (1997)
- Co-receptors for HIV-1 entry. Moore, J.P., Trkola, A., Dragic, T. Curr. Opin. Immunol. (1997)
- Redox regulation of chemokine receptor expression. Saccani, A., Saccani, S., Orlando, S., Sironi, M., Bernasconi, S., Ghezzi, P., Mantovani, A., Sica, A. Proc. Natl. Acad. Sci. U.S.A. (2000)
- CXCR4 and CXCL12 (SDF-1) in prostate cancer: inhibitory effects of human single chain Fv antibodies. Vaday, G.G., Hua, S.B., Peehl, D.M., Pauling, M.H., Lin, Y.H., Zhu, L., Lawrence, D.M., Foda, H.D., Zucker, S. Clin. Cancer Res. (2004)
- Identification of the cytoplasmic domains of CXCR4 involved in Jak2 and STAT3 phosphorylation. Ahr, B., Denizot, M., Robert-Hebmann, V., Brelot, A., Biard-Piechaczyk, M. J. Biol. Chem. (2005)
- Synthetic peptides for AIDS research. Di Bello, C., Pasquato, A., Dettin, M. Curr. Protein Pept. Sci. (2004)
- Transcriptional down-regulation of CXC chemokine receptor 4 induced by impaired association of transcription regulator YY1 with c-Myc in human herpesvirus 6-infected cells. Hasegawa, A., Yasukawa, M., Sakai, I., Fujita, S. J. Immunol. (2001)
- NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4. Helbig, G., Christopherson, K.W., Bhat-Nakshatri, P., Kumar, S., Kishimoto, H., Miller, K.D., Broxmeyer, H.E., Nakshatri, H. J. Biol. Chem. (2003)
- The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway. Vila-Coro, A.J., Rodríguez-Frade, J.M., Martín De Ana, A., Moreno-Ortíz, M.C., Martínez-A, C., Mellado, M. FASEB J. (1999)
- Syndecan-4 is a signaling molecule for stromal cell-derived factor-1 (SDF-1)/ CXCL12. Charnaux, N., Brule, S., Hamon, M., Chaigneau, T., Saffar, L., Prost, C., Lievre, N., Gattegno, L. FEBS J. (2005)
- Comodulation of CXCR4 and CD26 in human lymphocytes. Herrera, C., Morimoto, C., Blanco, J., Mallol, J., Arenzana, F., Lluis, C., Franco, R. J. Biol. Chem. (2001)
- The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Oberlin, E., Amara, A., Bachelerie, F., Bessia, C., Virelizier, J.L., Arenzana-Seisdedos, F., Schwartz, O., Heard, J.M., Clark-Lewis, I., Legler, D.F., Loetscher, M., Baggiolini, M., Moser, B. Nature (1996)
- Cloning and analysis of the promoter region of CXCR4, a coreceptor for HIV-1 entry. Moriuchi, M., Moriuchi, H., Turner, W., Fauci, A.S. J. Immunol. (1997)
- Differential regulation of CXCR4 and CCR5 endocytosis. Signoret, N., Rosenkilde, M.M., Klasse, P.J., Schwartz, T.W., Malim, M.H., Hoxie, J.A., Marsh, M. J. Cell. Sci. (1998)
- CXCR4 and VEGF expression in the primary site and the metastatic site of human osteosarcoma: analysis within a group of patients, all of whom developed lung metastasis. Oda, Y., Yamamoto, H., Tamiya, S., Matsuda, S., Tanaka, K., Yokoyama, R., Iwamoto, Y., Tsuneyoshi, M. Mod. Pathol. (2006)
- Arrestin-2 interacts with the ubiquitin-protein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4. Bhandari, D., Trejo, J., Benovic, J.L., Marchese, A. J. Biol. Chem. (2007)
- Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation. Mines, M.A., Goodwin, J.S., Limbird, L.E., Cui, F.F., Fan, G.H. J. Biol. Chem. (2009)
- Regulation of CXCR3 and CXCR4 expression during terminal differentiation of memory B cells into plasma cells. Muehlinghaus, G., Cigliano, L., Huehn, S., Peddinghaus, A., Leyendeckers, H., Hauser, A.E., Hiepe, F., Radbruch, A., Arce, S., Manz, R.A. Blood (2005)
- Functional expression of CCR1, CCR3, CCR4, and CXCR4 chemokine receptors on human platelets. Clemetson, K.J., Clemetson, J.M., Proudfoot, A.E., Power, C.A., Baggiolini, M., Wells, T.N. Blood (2000)
- Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling. Balabanian, K., Levoye, A., Klemm, L., Lagane, B., Hermine, O., Harriague, J., Baleux, F., Arenzana-Seisdedos, F., Bachelerie, F. J. Clin. Invest. (2008)
- Bone marrow CD34(+) cells and megakaryoblasts secrete beta-chemokines that block infection of hematopoietic cells by M-tropic R5 HIV. Majka, M., Rozmyslowicz, T., Lee, B., Murphy, S.L., Pietrzkowski, Z., Gaulton, G.N., Silberstein, L., Ratajczak, M.Z. J. Clin. Invest. (1999)
- WHIM syndrome myelokathexis reproduced in the NOD/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with C-terminus-truncated CXCR4. Kawai, T., Choi, U., Cardwell, L., Deravin, S.S., Naumann, N., Whiting-Theobald, N.L., Linton, G.F., Moon, J., Murphy, P.M., Malech, H.L. Blood (2007)
- Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor. Zagzag, D., Krishnamachary, B., Yee, H., Okuyama, H., Chiriboga, L., Ali, M.A., Melamed, J., Semenza, G.L. Cancer Res. (2005)