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Gene: FTO  -  fat mass and obesity associated

Homo sapiens

Synonyms: Fat mass and obesity-associated protein, fatso, KIAA1752, MGC5149, Protein fatso
 
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Disease relevance of FTO

  • CONCLUSIONS: A minimum of three intervals of FTO is necessary to determine whether an amblyopia patient will be unresponsive to occlusion therapy [1].
  • In contrast, HBV ccc DNA, HBV precore/core and X mRNAs, and replicative intermediates were not demonstrable in FTO 2B rat hepatoma cells infected in the same manner in parallel experiments [2].
 

High impact information on FTO

  • Of the 44 occlusion trials consisting of two FTO intervals without improvement, visual acuity improved after the third FTO interval in 12 (27%) of the trials [1].
  • Several typical bone proteins, including collagen I, osteocalcin, alkaline phosphatase and FATSO, were also expressed at significantly higher levels in teeth than in bone, probably due to the extreme growth rate of rat incisors [3].
  • The role of the conducting glass substrate (fluorine-doped tin oxide, FTO) in the back reaction of electrons with tri-iodide ions in dye-sensitized nanocrystalline solar cells (DSCs) has been investigated using thin-layer electrochemical cells that are analogues of the DSCs [4].
 

Biological context of FTO

References

  1. The minimum occlusion trial for the treatment of amblyopia. Keech, R.V., Ottar, W., Zhang, L. Ophthalmology (2002)
  2. Hepatitis B virus infection in microcarrier-attached immortalized human hepatocytes cultured in molecularporous membrane bags: a model for long-term episomal replication of HBV. Gong, Z.J., De Meyer, S., Roskams, T., van Pelt, J.F., Soumillion, A., Crabbé, T., Yap, S.H. J. Viral Hepat. (1998)
  3. Expression of phosphoproteins and amelotin in teeth. Trueb, B., Taeschler, S., Schild, C., Lang, N.P. Int. J. Mol. Med. (2007)
  4. How important is the back reaction of electrons via the substrate in dye-sensitized nanocrystalline solar cells? Cameron, P.J., Peter, L.M., Hore, S. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical. (2005)
 
 
 
 
 
 
 
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