The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

WDR77  -  WD repeat domain 77

Homo sapiens

Synonyms: Androgen receptor cofactor p44, HKMT1069, MEP-50, MEP50, Methylosome protein 50, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on WDR77

  • PRMT5 and its cofactor MEP50 were identified as specific MBD2/NuRD interactors [1].
  • As the PMRT5/MEP50 complex is involved in ribonucleoprotein complex assembly, we hypothesize that the Vls complex may play a similar function in assembling the nuage in nurse cells and the polar granules in the oocyte [2].
  • We show that MEP50 is important for methylosome activity and binds to JBP1 and to a subset of Sm proteins [3].
  • Here, we describe a novel component of the methylosome, a 50-kilodalton WD repeat protein termed methylosome protein 50 (MEP50) [3].
 

Other interactions of WDR77

  • Because WD repeat proteins provide a platform for multiple protein interactions, MEP50 may function to mediate the interaction of multiple substrates with the methylosome [3].

References

  1. MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties. Le Guezennec, X., Vermeulen, M., Brinkman, A.B., Hoeijmakers, W.A., Cohen, A., Lasonder, E., Stunnenberg, H.G. Mol. Cell. Biol. (2006) [Pubmed]
  2. Valois, a component of the nuage and pole plasm, is involved in assembly of these structures, and binds to Tudor and the methyltransferase Capsuléen. Anne, J., Mechler, B.M. Development (2005) [Pubmed]
  3. A novel WD repeat protein component of the methylosome binds Sm proteins. Friesen, W.J., Wyce, A., Paushkin, S., Abel, L., Rappsilber, J., Mann, M., Dreyfuss, G. J. Biol. Chem. (2002) [Pubmed]
 
WikiGenes - Universities