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Gene Review

DEK  -  DEK proto-oncogene

Homo sapiens

Synonyms: D6S231E, Protein DEK
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Disease relevance of DEK


High impact information on DEK


Biological context of DEK


Anatomical context of DEK

  • Significantly, DEK remains bound to the exon-product RNA after splicing, and this association requires the prior formation of a spliceosome [5].
  • We demonstrate the ability of recombinant DEK to bind specifically to the pets site using the electrophoretic mobility shift assay (EMSA) and DNase I footprinting. "Supershift" EMSA further confirms that DEK is the dominant protein binding to the pets site in T cell extracts [2].
  • Cervical cancer cell senescence was partially overcome by DEK overexpression, and DEK overexpression was sufficient for extending the life span of primary keratinocytes, supporting critical roles for this molecule as a senescence regulator [9].
  • We report here the specific repression of DEK message and protein levels in senescing human papillomavirus type 16- (HPV16-) and HPV18-positive cancer cell lines as well as in primary cells undergoing replicative senescence [9].
  • We demonstrate here that DEK is actively secreted by macrophages and is also found in synovial fluid samples from patients with juvenile arthritis [10].

Associations of DEK with chemical compounds


Physical interactions of DEK

  • Finally, electrophoretic mobility shift assays suggested that DEK enhances the DNA-binding activity of AP-2alpha [7].
  • These results indicate that several nonameric peptides derived from the DEK protein can bind to HLA-A 0201 and suggest that the complexes formed may be able to stimulate CD8+ T cells in patients with Pauciarticular Juvenile Arthritis [14].
  • Measurement of the apparent dissociation constants demonstrated a two- to fivefold difference in DEK binding to the DQA1 Y-box sequence in comparison with other class II MHC Y-box sequences [15].

Other interactions of DEK

  • Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek [16].
  • SNP-based association studies of the region identified a 4-marker haplotype in the DEK gene that was significantly associated with RA (P = 0.009) [17].
  • The remaining 20 (26%) samples showed gains only at some loci, most often including E2F3 and DEK in 6p22 [3].
  • The t(6;9)(p23;q34) is a recurrent chromosomal abnormality observed in 1% of acute myelogenous leukemia (AML), which generates a fusion transcript between DEK and CAN/NUP214 genes [18].
  • Most of the DEK protein was found to be released by DNase treatment of nuclei, and only a small amount by treatment with RNase [11].

Analytical, diagnostic and therapeutic context of DEK


  1. Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis. Larramendy, M.L., Niini, T., Elonen, E., Nagy, B., Ollila, J., Vihinen, M., Knuutila, S. Haematologica (2002) [Pubmed]
  2. DEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancer. Fu, G.K., Grosveld, G., Markovitz, D.M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  3. Gains and overexpression identify DEK and E2F3 as targets of chromosome 6p gains in retinoblastoma. Grasemann, C., Gratias, S., Stephan, H., Schüler, A., Schramm, A., Klein-Hitpass, L., Rieder, H., Schneider, S., Kappes, F., Eggert, A., Lohmann, D.R. Oncogene (2005) [Pubmed]
  4. The protein encoded by the proto-oncogene DEK changes the topology of chromatin and reduces the efficiency of DNA replication in a chromatin-specific manner. Alexiadis, V., Waldmann, T., Andersen, J., Mann, M., Knippers, R., Gruss, C. Genes Dev. (2000) [Pubmed]
  5. The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes. McGarvey, T., Rosonina, E., McCracken, S., Li, Q., Arnaout, R., Mientjes, E., Nickerson, J.A., Awrey, D., Greenblatt, J., Grosveld, G., Blencowe, B.J. J. Cell Biol. (2000) [Pubmed]
  6. YY1 and NF-Y binding sites regulate the transcriptional activity of the dek and dek-can promoter. Sitwala, K.V., Adams, K., Markovitz, D.M. Oncogene (2002) [Pubmed]
  7. Transcriptional activation by AP-2alpha is modulated by the oncogene DEK. Campillos, M., García, M.A., Valdivieso, F., Vázquez, J. Nucleic Acids Res. (2003) [Pubmed]
  8. Functional domains of the ubiquitous chromatin protein DEK. Kappes, F., Scholten, I., Richter, N., Gruss, C., Waldmann, T. Mol. Cell. Biol. (2004) [Pubmed]
  9. The human DEK proto-oncogene is a senescence inhibitor and an upregulated target of high-risk human papillomavirus E7. Wise-Draper, T.M., Allen, H.V., Thobe, M.N., Jones, E.E., Habash, K.B., Münger, K., Wells, S.I. J. Virol. (2005) [Pubmed]
  10. The DEK Nuclear Autoantigen Is a Secreted Chemotactic Factor. Mor-Vaknin, N., Punturieri, A., Sitwala, K., Faulkner, N., Legendre, M., Khodadoust, M.S., Kappes, F., Ruth, J.H., Koch, A., Glass, D., Petruzzelli, L., Adams, B.S., Markovitz, D.M. Mol. Cell. Biol. (2006) [Pubmed]
  11. Subcellular localization of the human proto-oncogene protein DEK. Kappes, F., Burger, K., Baack, M., Fackelmayer, F.O., Gruss, C. J. Biol. Chem. (2001) [Pubmed]
  12. Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomes. Krithivas, A., Fujimuro, M., Weidner, M., Young, D.B., Hayward, S.D. J. Virol. (2002) [Pubmed]
  13. The oncogene DEK promotes leukemic cell survival and is downregulated by both Nutlin-3 and chlorambucil in B-chronic lymphocytic leukemic cells. Secchiero, P., Voltan, R., di Iasio, M.G., Melloni, E., Tiribelli, M., Zauli, G. Clin. Cancer Res. (2010) [Pubmed]
  14. Juvenile arthritis, HLA-A2 and binding of DEK oncogene-peptides. Forero, L., Zwirner, N.W., Fink, C.W., Fernández-Viña, M.A., Stastny, P. Hum. Immunol. (1998) [Pubmed]
  15. DEK binding to class II MHC Y-box sequences is gene- and allele-specific. Adams, B.S., Cha, H.C., Cleary, J., Haiying, T., Wang, H., Sitwala, K., Markovitz, D.M. Arthritis Res. Ther. (2003) [Pubmed]
  16. Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek. Hollenbach, A.D., McPherson, C.J., Mientjes, E.J., Iyengar, R., Grosveld, G. J. Cell. Sci. (2002) [Pubmed]
  17. Evidence for a novel rheumatoid arthritis susceptibility locus on chromosome 6p. Brintnell, W., Zeggini, E., Barton, A., Thomson, W., Eyre, S., Hinks, A., Silman, A.J., Worthington, J. Arthritis Rheum. (2004) [Pubmed]
  18. DEK-CAN molecular monitoring of myeloid malignancies could aid therapeutic stratification. Garçon, L., Libura, M., Delabesse, E., Valensi, F., Asnafi, V., Berger, C., Schmitt, C., Leblanc, T., Buzyn, A., Macintyre, E. Leukemia (2005) [Pubmed]
  19. The ubiquitous chromatin protein DEK alters the structure of DNA by introducing positive supercoils. Waldmann, T., Eckerich, C., Baack, M., Gruss, C. J. Biol. Chem. (2002) [Pubmed]
  20. Expression analysis of 6p22 genomic gain in retinoblastoma. Orlic, M., Spencer, C.E., Wang, L., Gallie, B.L. Genes Chromosomes Cancer (2006) [Pubmed]
  21. Identification of the p33(ING1)-regulated genes that include cyclin B1 and proto-oncogene DEK by using cDNA microarray in a mouse mammary epithelial cell line NMuMG. Takahashi, M., Seki, N., Ozaki, T., Kato, M., Kuno, T., Nakagawa, T., Watanabe, K., Miyazaki, K., Ohira, M., Hayashi, S., Hosoda, M., Tokita, H., Mizuguchi, H., Hayakawa, T., Todo, S., Nakagawara, A. Cancer Res. (2002) [Pubmed]
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