The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Rab27b  -  RAB27B, member RAS oncogene family

Mus musculus

Synonyms: 2310021G14Rik, B130064M09Rik, Ras-related protein Rab-27B
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Rab27b

 

Associations of Rab27b with chemical compounds

  • In vitro assays demonstrated impaired aggregation with collagen and U46619 and reduced secretion of dense granules in both Rab27b and double KO strains [3].
 

Biological context of Rab27b

  • Normal expression of Rab27b is especially increased with terminal megakaryocyte differentiation and dependent on nuclear factor-erythroid 2 (NF-E2), a transcription factor required for thrombopoiesis [4].
  • These findings indicate that Rab27b is involved in pituitary hormone secretion, which further supports the idea that members of the Rab27 subfamily regulate the exocytosis of dense core granules containing peptide hormones in endocrine cells [5].
  • The mouse Rab27b cDNA shows 95% identity with the human cDNA at the protein level and maps to mouse chromosome 18 [6].
 

Anatomical context of Rab27b

 

Other interactions of Rab27b

References

  1. Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome. Barral, D.C., Ramalho, J.S., Anders, R., Hume, A.N., Knapton, H.J., Tolmachova, T., Collinson, L.M., Goulding, D., Authi, K.S., Seabra, M.C. J. Clin. Invest. (2002) [Pubmed]
  2. Rab27b is associated with fusiform vesicles and may be involved in targeting uroplakins to urothelial apical membranes. Chen, Y., Guo, X., Deng, F.M., Liang, F.X., Sun, W., Ren, M., Izumi, T., Sabatini, D.D., Sun, T.T., Kreibich, G. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. Rab27b regulates number and secretion of platelet dense granules. Tolmachova, T., Abrink, M., Futter, C.E., Authi, K.S., Seabra, M.C. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  4. A role for Rab27b in NF-E2-dependent pathways of platelet formation. Tiwari, S., Italiano, J.E., Barral, D.C., Mules, E.H., Novak, E.K., Swank, R.T., Seabra, M.C., Shivdasani, R.A. Blood (2003) [Pubmed]
  5. Involvement of Rab27b in the regulated secretion of pituitary hormones. Zhao, S., Torii, S., Yokota-Hashimoto, H., Takeuchi, T., Izumi, T. Endocrinology (2002) [Pubmed]
  6. Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene. Ramalho, J.S., Tolmachova, T., Hume, A.N., McGuigan, A., Gregory-Evans, C.Y., Huxley, C., Seabra, M.C. BMC Genet. (2001) [Pubmed]
  7. Rab27b association with melanosomes: dominant negative mutants disrupt melanosomal movement. Chen, Y., Samaraweera, P., Sun, T.T., Kreibich, G., Orlow, S.J. J. Invest. Dermatol. (2002) [Pubmed]
 
WikiGenes - Universities