The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

TMX1  -  thioredoxin-related transmembrane protein 1

Homo sapiens

Synonyms: PDIA11, PSEC0085, TMX, TXNDC, TXNDC1, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of TXNDC1

  • Synthetic iron(II) porphyrin (FeP) is equivalently incorporated into recombinant Thermotoga maritima xylanase B (TMX; family F/10 of glycoside hydrolase), producing a heat-resistant artificial hemoprotein (TMX-FeP) that can bind and release oxygen (O(2)) in aqueous medium (pH 7.3, 25 degrees C) in the same manner as hemoglobin and myoglobin [1].
  • CONCLUSION: Sequence-dependent administration of RAL in combination with 5-FU/TMX can act against TMX toxicity in human bone marrow, while not affecting the maximum inhibitory effect of TMX in breast cancer [2].
 

Psychiatry related information on TXNDC1

  • These findings suggest that work satisfaction is explained largely by job characteristics (through empowerment) but that LMX and TMX combine with job characteristics and empowerment to explain variation in organizational commitment and job performance [3].
 

High impact information on TXNDC1

 

Biological context of TXNDC1

 

Anatomical context of TXNDC1

  • The TMX transcript is widely expressed in normal human tissues, and subcellular fractionation and immunostaining for an epitope-tagged TMX protein suggest that TMX is predominantly localized in the endoplasmic reticulum (ER) [5].
  • Moreover, post-TCT proportions of all and CD8+ lymphocytes as well as absolute numbers of all and CD4+ and CD8+ lymphocytes in TMX patients were significantly increased in comparison to the same parameters in control post-TCT patients, although there was no difference between the two subgroups before TCT [8].
  • At the other hand, granulocyte ingestion was decreased in post-TCT TMX patients compared to post-TCT values in control patients and NK cell activity showed a similar, although statistically not significant, tendency [8].
  • RESULTS: The growth rate in MCF-7 in late RAL was 34.75 +/- 4.79% of the control, whereas in bone marrow the same drug combination exhibits a significant protection against TMX cytotoxicity with late RAL yielding 51.25 +/- 4.43% of the control [2].
  • A total of thirty-nine patients with coronary artery disease and positive TMX results in 1988 was studied [9].
 

Associations of TXNDC1 with chemical compounds

  • The design permitted confirmation of most of the partial results in various experimental settings and contributed new data on the metabolic disposition of TMX, with specific reference to main dimethylxanthine metabolite found in plasma, paraxanthine (1,7-dimethylxanthine) [6].
  • In addition to providing a comprehensive profile of TMS disposition in the healthy adult, the results indicate tha TMX exhibits dose-independent kinetics at the levels at which man normally takes TMX [6].
  • It seems that TMX helps recovery of lymphocyte populations decreased by radiotherapy, probably by stimulation of cells carrying estrogen receptors, but its effects on phagocytic functions and probably NK cell activity seemed to be rather inhibitory than stimulatory [8].
  • This was achieved by introduction of siRNA targeting exon 3 to a Tamoxifen-selected MCF-7 variant, TMX 2-11, expressing approximately equal amount of full-length ER and ERDelta3 proteins [10].
  • The aim of this study was to evaluate RAL in combination with 5-fluorouracil (5-FU)/trimetrexate (TMX) to determine the most effective regimes and cellular mechanism of action to mitigate trimetrexate cytotoxicity in human bone marrow cells [2].
 

Analytical, diagnostic and therapeutic context of TXNDC1

  • Here we report the molecular cloning and characterization of one of these genes, designated TMX, that encodes a novel protein of 280 amino acid residues [5].
  • TMX and its metabolites were analyzed in plasma and urine by high-pressure liquid chromatography [6].
  • In control group, proportion of all lymphocytes and CD8+ cells as well as absolute number of all lymphocytes, CD4+, CD8+, CD16+ and B lymphocytes were decreased following TCT in comparison to their pre-TCT values, while in TMX group only absolute number of all lymphocytes remained decreased following TCT [8].
  • The results of treadmill exercise stress test (TMX) for ischaemia is based on ST-segment depression [9].

References

  1. Heat-resistant oxygen-carrying hemoproteins consist of recombinant xylanases and synthetic iron(II) porphyrin. Komatsu, T., Ishihara, S., Tsuchida, E., Nishide, H., Morokuma, C., Nakamura, S. Biomacromolecules (2005) [Pubmed]
  2. The protection against trimetrexate cytotoxicity in human bone marrow by sequence-dependent administration of raloxifene, 5-fluorouracil/trimetrexate. Das, J.R., Fryar, E.B., Green, S., Southerland, W.M., Bowen, D. Anticancer Res. (2006) [Pubmed]
  3. An examination of the mediating role of psychological empowerment on the relations between the job, interpersonal relationships, and work outcomes. Liden, R.C., Wayne, S.J., Sparrowe, R.T. The Journal of applied psychology. (2000) [Pubmed]
  4. Identification and characterization of a novel thioredoxin-related transmembrane protein of the endoplasmic reticulum. Haugstetter, J., Blicher, T., Ellgaard, L. J. Biol. Chem. (2005) [Pubmed]
  5. Identification of a novel thioredoxin-related transmembrane protein. Matsuo, Y., Akiyama, N., Nakamura, H., Yodoi, J., Noda, M., Kizaka-Kondoh, S. J. Biol. Chem. (2001) [Pubmed]
  6. Caffeine disposition after oral doses. Bonati, M., Latini, R., Galletti, F., Young, J.F., Tognoni, G., Garattini, S. Clin. Pharmacol. Ther. (1982) [Pubmed]
  7. TMX, a human transmembrane oxidoreductase of the thioredoxin family: the possible role in disulfide-linked protein folding in the endoplasmic reticulum. Matsuo, Y., Nishinaka, Y., Suzuki, S., Kojima, M., Kizaka-Kondoh, S., Kondo, N., Son, A., Sakakura-Nishiyama, J., Yamaguchi, Y., Masutani, H., Ishii, Y., Yodoi, J. Arch. Biochem. Biophys. (2004) [Pubmed]
  8. Natural killer cell activity, phagocytosis, and number of peripheral blood cells in breast cancer patients treated with tamoxifen. Lukac, J., Kusić, Z., Kordić, D., Koncar, M., Bolanca, A. Breast Cancer Res. Treat. (1994) [Pubmed]
  9. Silent myocardial ischaemia: the Tan Tock Seng experience. Mak, K.H., Tan, E.K., Chew, L., Gan, S.H., Chan, A.L. Singapore medical journal. (1991) [Pubmed]
  10. Gene regulation in an MCF-7 cell line that naturally expresses an estrogen receptor unable to directly bind DNA. Pentecost, B.T., Bradley, L.M., Gierthy, J.F., Ding, Y., Fasco, M.J. Mol. Cell. Endocrinol. (2005) [Pubmed]
 
WikiGenes - Universities