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Gene Review

PDRG1  -  p53 and DNA-damage regulated 1

Homo sapiens

Synonyms: C20orf126, PDRG, dJ310O13.3, p53 and DNA damage-regulated protein 1
 
 
 
 
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High impact information on PDRG1

  • Human PDRG is predominantly expressed in normal testis and exhibits reduced but detectable expression in other organs [1].
  • The human and mouse PDRG sequences are highly homologous and contain open reading frames of 133 amino acids each with molecular masses of 15.5 and 15.3 kDa, respectively [1].
  • Indeed, UV as well as exogenous Oct-1 independently increased PDRG promoter activity, suggesting that UV could mediate PDRG upregulation via Oct-1 [1].
 

Analytical, diagnostic and therapeutic context of PDRG1

  • Cloning and sequence analysis of PDRG promoter revealed the presence of Oct-1-binding element and a putative head-to-tail-type p53-binding site [1].

References

 
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