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ABH1  -  nuclear cap-binding protein subunit 1

Arabidopsis thaliana

Synonyms: ABA HYPERSENSITIVE 1, ATCBP80, CAP-BINDING PROTEIN 80, CBP80, ENS, ...
 
 
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Disease relevance of ABH1

  • Moreover, expression of a 35SAtPP2CA cDNA fusion in abh1 partially suppresses abh1 hypersensitivity, and the data further suggest that additional mechanisms contribute to ABA hypersensitivity of abh1 [1].
 

High impact information on ABH1

 

Biological context of ABH1

 

Anatomical context of ABH1

  • Complemented abh1 lines expressing a green fluorescent protein-ABH1 fusion protein demonstrate that ABH1 mainly localizes in guard cell nuclei [6].
  • The second subunit of the Arabidopsis cap-binding complex, AtCBP80, shows 28% identity and 50% similarity to its homologue from HeLa cells [7].
 

Associations of ABH1 with chemical compounds

  • Molecular analysis showed that the mutations are caused by lesions in the gene encoding the large subunit of the nuclear mRNA cap-binding protein, ABH1 (ABA hypersensitive1) [8].
 

Regulatory relationships of ABH1

 

Other interactions of ABH1

 

Analytical, diagnostic and therapeutic context of ABH1

  • DNA chip analyses show that only a few transcripts are down-regulated in abh1, several of which are implicated in ABA signaling [2].

References

  1. The protein phosphatase AtPP2CA negatively regulates abscisic acid signal transduction in Arabidopsis, and effects of abh1 on AtPP2CA mRNA. Kuhn, J.M., Boisson-Dernier, A., Dizon, M.B., Maktabi, M.H., Schroeder, J.I. Plant Physiol. (2006) [Pubmed]
  2. An mRNA cap binding protein, ABH1, modulates early abscisic acid signal transduction in Arabidopsis. Hugouvieux, V., Kwak, J.M., Schroeder, J.I. Cell (2001) [Pubmed]
  3. Mitogen-activated protein kinase signaling in postgermination arrest of development by abscisic acid. Lu, C., Han, M.H., Guevara-Garcia, A., Fedoroff, N.V. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  4. Mutation of SAD2, an importin beta-domain protein in Arabidopsis, alters abscisic acid sensitivity. Verslues, P.E., Guo, Y., Dong, C.H., Ma, W., Zhu, J.K. Plant J. (2006) [Pubmed]
  5. Enhancement of abscisic acid sensitivity and reduction of water consumption in Arabidopsis by combined inactivation of the protein phosphatases type 2C ABI1 and HAB1. Saez, A., Robert, N., Maktabi, M.H., Schroeder, J.I., Serrano, R., Rodriguez, P.L. Plant Physiol. (2006) [Pubmed]
  6. Localization, ion channel regulation, and genetic interactions during abscisic acid signaling of the nuclear mRNA cap-binding protein, ABH1. Hugouvieux, V., Murata, Y., Young, J.J., Kwak, J.M., Mackesy, D.Z., Schroeder, J.I. Plant Physiol. (2002) [Pubmed]
  7. Cloning and characterization of two subunits of Arabidopsis thaliana nuclear cap-binding complex. Kmieciak, M., Simpson, C.G., Lewandowska, D., Brown, J.W., Jarmolowski, A. Gene (2002) [Pubmed]
  8. Lesions in the mRNA cap-binding gene ABA HYPERSENSITIVE 1 suppress FRIGIDA-mediated delayed flowering in Arabidopsis. Bezerra, I.C., Michaels, S.D., Schomburg, F.M., Amasino, R.M. Plant J. (2004) [Pubmed]
  9. Analysis of ABA hypersensitive germination2 revealed the pivotal functions of PARN in stress response in Arabidopsis. Nishimura, N., Kitahata, N., Seki, M., Narusaka, Y., Narusaka, M., Kuromori, T., Asami, T., Shinozaki, K., Hirayama, T. Plant J. (2005) [Pubmed]
  10. Gain-of-function and loss-of-function phenotypes of the protein phosphatase 2C HAB1 reveal its role as a negative regulator of abscisic acid signalling. Saez, A., Apostolova, N., Gonzalez-Guzman, M., Gonzalez-Garcia, M.P., Nicolas, C., Lorenzo, O., Rodriguez, P.L. Plant J. (2004) [Pubmed]
 
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