The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

MSH2  -  DNA mismatch repair protein Msh2

Arabidopsis thaliana

Synonyms: ATMSH2, MUTS homolog 2
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on MSH2

 

Associations of MSH2 with chemical compounds

  • The Arabidopsis thaliana MSH2 (AtMSH2) gene encodes a protein that belongs to a family of highly conserved proteins (MutS homologues (MSH)) involved in DNA mismatch repair [4].
 

Other interactions of MSH2

  • Comparative analysis of the AtMSH2 Landsberg erecta genomic sequence (reported here) and the previously described AtMSH2 Columbia allele revealed several polymorphisms, including the presence of a small, transposon-like element in the 3' untranscribed region of the former allele [3].
 

Analytical, diagnostic and therapeutic context of MSH2

  • Sequence analysis strongly suggests that this single copy gene is indeed a homologue of MSH2, a gene known to play a central role in eukaryotic mismatch repair [4].
  • Second, gel retardation assays revealed that the AtMSH2 protein has a 10-fold greater affinity for DNA containing a single pair of mismatched nucleotides versus perfectly matched DNA [4].

References

  1. The role of AtMSH2 in homologous recombination in Arabidopsis thaliana. Emmanuel, E., Yehuda, E., Melamed-Bessudo, C., Avivi-Ragolsky, N., Levy, A.A. EMBO Rep. (2006) [Pubmed]
  2. Reduction of stability of arabidopsis genomic and transgenic DNA-repeat sequences (microsatellites) by inactivation of AtMSH2 mismatch-repair function. Leonard, J.M., Bollmann, S.R., Hays, J.B. Plant Physiol. (2003) [Pubmed]
  3. Four mismatch repair paralogues coexist in Arabidopsis thaliana: AtMSH2, AtMSH3, AtMSH6-1 and AtMSH6-2. Adé, J., Belzile, F., Philippe, H., Doutriaux, M.P. Mol. Gen. Genet. (1999) [Pubmed]
  4. Functional analysis of the Arabidopsis thaliana mismatch repair gene MSH2. Adé, J., Haffani, Y., Beizile, F.J. Genome (2001) [Pubmed]
 
WikiGenes - Universities