Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

TPS5 - alpha,alpha-trehalose-phosphate synthase...

Arabidopsis thaliana

Synonyms: ATTPS5, At4g17770, AtTPS5, DL4920W, FCAALL.9, ...

Harthill, J.E. et al., Schluepmann, H. et al.

Schluepmann, van Dijken, Aghdasi, Wobbes, Paul, Smeekens,

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High impact information on ATTPS5

2-deoxyglucose stimulated Thr49 phosphorylation of endogenous TPS5 in Arabidopsis cells, whereas phenformin did not [1].
Expression analysis of genes from the Arabidopsis trehalose metabolism further supports this: Suc rapidly induces expression of trehalose phosphate synthase homolog AtTPS5 to high levels [2].

Analytical, diagnostic and therapeutic context of ATTPS5

In this paper, we show that TPS5, 6 and 7 are phosphoproteins that bind to 14-3-3 proteins, by using 14-3-3 affinity chromatography, 14-3-3 overlay assays, and by co-immunoprecipitating TPS5 and 14-3-3 isoforms from cell extracts [1].

References

Phosphorylation and 14-3-3 binding of Arabidopsis trehalose-phosphate synthase 5 in response to 2-deoxyglucose. Harthill, J.E., Meek, S.E., Morrice, N., Peggie, M.W., Borch, J., Wong, B.H., Mackintosh, C. Plant J. (2006) [Pubmed]
Trehalose mediated growth inhibition of Arabidopsis seedlings is due to trehalose-6-phosphate accumulation. Schluepmann, H., van Dijken, A., Aghdasi, M., Wobbes, B., Paul, M., Smeekens, S. Plant Physiol. (2004) [Pubmed]

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