Gene Review:
AXIN2 - axin 2
Homo sapiens
Synonyms:
AXIL, Axil, Axin-2, Axin-like protein, Axis inhibition protein 2, ...
- Colorectal cancer and genetic alterations in the Wnt pathway. Segditsas, S., Tomlinson, I. Oncogene (2006)
- Mutations and elevated transcriptional activity of conductin (AXIN2) in hepatoblastomas. Koch, A., Weber, N., Waha, A., Hartmann, W., Denkhaus, D., Behrens, J., Birchmeier, W., von Schweinitz, D., Pietsch, T. J. Pathol. (2004)
- Genomic structure, chromosome mapping and expression analysis of the human AXIN2 gene. Dong, X., Seelan, R.S., Qian, C., Mai, M., Liu, W. Cytogenet. Cell Genet. (2001)
- Single nucleotide polymorphism of the AXIN2 gene is preferentially associated with human lung cancer risk in a Japanese population. Kanzaki, H., Ouchida, M., Hanafusa, H., Yano, M., Suzuki, H., Aoe, M., Imai, K., Shimizu, N., Nakachi, K., Shimizu, K. Int. J. Mol. Med. (2006)
- Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling. Liu, W., Dong, X., Mai, M., Seelan, R.S., Taniguchi, K., Krishnadath, K.K., Halling, K.C., Cunningham, J.M., Boardman, L.A., Qian, C., Christensen, E., Schmidt, S.S., Roche, P.C., Smith, D.I., Thibodeau, S.N. Nat. Genet. (2000)
- Regulation of gene expression by alternative untranslated regions. Hughes, T.A. Trends Genet. (2006)
- Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancer. Hadjihannas, M.V., Brückner, M., Jerchow, B., Birchmeier, W., Dietmaier, W., Behrens, J. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Genetic and epigenetic changes of components affecting the WNT pathway in colorectal carcinomas stratified by microsatellite instability. Thorstensen, L., Lind, G.E., Løvig, T., Diep, C.B., Meling, G.I., Rognum, T.O., Lothe, R.A. Neoplasia (2005)
- Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. Lammi, L., Arte, S., Somer, M., Jarvinen, H., Lahermo, P., Thesleff, I., Pirinen, S., Nieminen, P. Am. J. Hum. Genet. (2004)
- Epigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instability. Koinuma, K., Yamashita, Y., Liu, W., Hatanaka, H., Kurashina, K., Wada, T., Takada, S., Kaneda, R., Choi, Y.L., Fujiwara, S.I., Miyakura, Y., Nagai, H., Mano, H. Oncogene (2006)
- Control of beta-catenin signaling in tumor development. Behrens, J. Ann. N. Y. Acad. Sci. (2000)
- Craniosynostosis caused by Axin2 deficiency is mediated through distinct functions of beta-catenin in proliferation and differentiation. Liu, B., Yu, H.M., Hsu, W. Dev. Biol. (2007)
- Microsatellite instability in multifocal urothelial carcinoma and effect on BAX and AXIN2. Walsh, A.M., Bailly, G.G., Bell, D.G., Norman, R.W., Gupta, R., Zayed, E., Nassar, B.A. The Canadian journal of urology. (2003)
- Distribution of breeding and control of the filariasis vector Aedes samoanus in leaf axils of Pandanus in Samoa. Samarawickrema, W.A., Sone, F., Self, L.S., Cummings, R.F., Paulson, G.S. Med. Vet. Entomol. (1992)
- Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins. Liu, X., Rubin, J.S., Kimmel, A.R. Curr. Biol. (2005)
- Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling. Leung, J.Y., Kolligs, F.T., Wu, R., Zhai, Y., Kuick, R., Hanash, S., Cho, K.R., Fearon, E.R. J. Biol. Chem. (2002)
- Cross-talk between pRb/E2F and Wnt/beta-catenin pathways: E2F1 induces axin2 leading to repression of Wnt signalling and to increased cell death. Hughes, T.A., Brady, H.J. Exp. Cell Res. (2005)
- Axis inhibition protein 2 (AXIN2) polymorphisms may be a risk factor for selective tooth agenesis. Mostowska, A., Biedziak, B., Jagodzinski, P.P. J. Hum. Genet. (2006)
- E2F1 up-regulates the expression of the tumour suppressor axin2 both by activation of transcription and by mRNA stabilisation. Hughes, T.A., Brady, H.J. Biochem. Biophys. Res. Commun. (2005)
- Low frequency of AXIN2 mutations and high frequency of MUTYH mutations in patients with multiple polyposis. Lejeune, S., Guillemot, F., Triboulet, J.P., Cattan, S., Mouton, C., Porchet, N., Manouvrier, S., Buisine, M.P. Hum. Mutat. (2006)