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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

PCDH11Y  -  protocadherin 11 Y-linked

Homo sapiens

Synonyms: PCDH-PC, PCDH22, PCDHX, PCDHY
 
 
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High impact information on PCDH11Y

  • This indicates that PCDHX and PCDHY possess different promoter regions [1].
  • The open reading frames of PCDHX and PCDHY encode proteins of 1025 and 1037 amino acids respectively and specify seven extracellular cadherin domains [1].
  • These findings suggest a role for PCDHX and PCDHY in the brain, consistent with the involvement of protocadherins in segmental brain morphogenesis and function [1].
  • The X-(PCDHX) and Y-linked (PCDHY) genes share 98.1% nucleotide and 98.3% amino acid identity and have an identical gene structure of six exons [1].
 

Analytical, diagnostic and therapeutic context of PCDH11Y

  • We examined differences in patients with schizophrenic or schizoaffective psychosis in the genomic sequence of PCDHX and PCDHY in coding and adjacent intronic sequences using denaturing high performance liquid chromatography (DHPLC) [2].

References

  1. Conservation of PCDHX in mammals; expression of human X/Y genes predominantly in brain. Blanco, P., Sargent, C.A., Boucher, C.A., Mitchell, M., Affara, N.A. Mamm. Genome (2000) [Pubmed]
  2. ProtocadherinX/Y, a candidate gene-pair for schizophrenia and schizoaffective disorder: a DHPLC investigation of genomic sequence. Giouzeli, M., Williams, N.A., Lonie, L.J., DeLisi, L.E., Crow, T.J. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2004) [Pubmed]
 
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