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Gene Review

CDCA3  -  cell division cycle associated 3

Homo sapiens

Synonyms: C8, Cell division cycle-associated protein 3, GRCC8, Gene-rich cluster protein C8, TOME-1, ...
 
 
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Disease relevance of CDCA3

  • Recently, it has been shown that a missense mutation in alphaB-crystallin, R120G, is genetically linked to a desmin-related myopathy as well as to cataracts [Vicart, P., Caron, A., Guicheney, P., Li, A., Prevost, M.-C., Faure, A., Chateau, D., Chapon, F., Tome, F., Dupret, J.-M., et al. (1998) Nat. Genet. 20, 92-95] [1].
  • Jean Cruveilhier is usually credited with having first illustrated the lesions of multiple sclerosis in the second tome of his pathological atlas which bears the title date 1835 [2].
  • Galactorrhea was significantly (at least 75%) reduced in 76% of the 187 patients after an average treatment tome of 6.4 weeks, and was completely suppressed in 58% after 12.7 weeks [3].
  • The snail host of schistosomiasis in São Tomé [4].
  • Elephantiasis in São Tomé and Príncipe [5].
 

High impact information on CDCA3

  • Tome-1 itself is targeted for degradation by APC in G1 [6].
  • Tome-1, wee1, and the onset of mitosis: coupled destruction for timely entry [6].
  • I never imagined that I would be asked to write an autobiography in a microbiology tome [7].
  • Using various Tome-1 promoter/luciferase constructs, we showed that the CCAAT box located upstream of the transcription initiation site is important for the basal promoter activity [8].
  • In turn, Tome-1 itself is targeted for degradation by APC in the G1 phase of the cell cycle [8].
 

Chemical compound and disease context of CDCA3

  • Laryngeal sections from cadavers were submerged in a celloidin solution, a derivative of wallpaper plaster, and frozen to -15 degrees C. After preparation, axial and coronal cuts of 100 microm were made with a Macrocut Tome sectioning system [9].
  • A 48 year-old right-hand-dominant man presented to our institution with paresthesia and loss of feeling along the median nerve distribution of the right hand 1 week after undergoing minimally open carpal tunnel release with the Biomet Indiana Tome at another hospital [10].
 

Biological context of CDCA3

  • We identified a repressor element (cell-cycle-dependent element/cell cycle gene homology region) in the vicinity of the transcription start site, and mutations within this element diminished the cell-cycle-dependent transcriptional regulation of Tome-1 [8].
  • In the present study, we analyzed the human and mouse Tome-1 promoter regions [8].
  • Using synchronized cultures of NIH3T3 cells transfected with Tome-1 promoter/luciferase constructs, we showed that the promoter activity of Tome-1 is activated at the G2/M phase [8].
  • The levels of haplotype diversity within the lineages defined by two single-nucleotide polymorphisms (SNPs) (-13910 C/T and -22018 G/A) associated with human lactase persistence were assessed with four fast-evolving microsatellite loci in 794 chromosomes from Portugal, Italy, Fulbe from Cameroon, São Tomé and Mozambique [11].
  • The pattern of genetic variation of the lizard Mabuya maculilabris from São Tomé Island (Gulf of Guinea) was investigated using a combination of three mitochondrial DNA gene fragments [12].
 

Anatomical context of CDCA3

  • Consecutive conventional spiral tomographic examinations were carried out in both the left upper and lower premolar area, using a Cranex TOME multifunctional unit [13].
  • This is the first report of a complete median nerve transection using the revised carpal tunnel tome with a single-pass technique [10].
  • Induction of hypoxia to a PO2 of 50 mmHg or increasing basal tome with 30 mM KCl did not diminish coronary artery response to prostaglandins, suggesting that prostaglandins released from ischemic myocardial tissue may influence coronary arterial tone [14].
 

Associations of CDCA3 with chemical compounds

  • Tomé, where they are used in Traditional Medicine mainly as febrifuge and for the treatment of respiratory diseases, were investigated [15].
  • Chloroquine resistance may be explained by the recent history of malaria in São Tomé Island, which caused an important decrease of immunity among the population and consequently the emergence of resistant strains [16].
  • Taken together, these results indicate that the peopling of São Tomé might have provided one of the first examples of the combination of diverse African contributions and European admixture that emerged from the overseas population relocations promoted by the Atlantic slave trade [17].
  • Haplotype analysis of the apolipoprotein E and apolipoprotein C1 loci in Portugal and São Tomé e Príncipe (Gulf of Guinea): linkage disequilibrium evidence that APOE*4 is the ancestral APOE allele [18].
  • OBJECTIVE: The authors carried out an experimental study to evaluate the histological alterations after irradiation of cartilage using Holmium:YAG (Ho:YAG) laser VersaPulse Select 60 watts and Infra Tome Delivery Systems 30 degrees Handpiece (spot size at fiber tip 0.4 mm; Coherent Medical, Palo Alto, CA) [19].
 

Analytical, diagnostic and therapeutic context of CDCA3

  • The sporozoite rate in São Tomé, assessed by ELISA, was 0.5% [20].
  • Overall prevalence, determined by PCR, was higher in São Tomé (53%) than in Príncipe (35%) [20].
  • A cross-sectional survey was carried out in 16 localities on the island of São Tomé and three on the island of Príncipe, at the end of the rainy season of 1997, to determine malaria prevalence and vector densities [20].
  • Comparative dose measurements by spiral tomography for preimplant diagnosis: the Scanora machine versus the Cranex Tome radiography unit [21].
  • Antimalarial activity of extracts and alkaloids isolated from six plants used in traditional medicine in Mali and Sao Tome [22].

References

  1. Mutation R120G in alphaB-crystallin, which is linked to a desmin-related myopathy, results in an irregular structure and defective chaperone-like function. Bova, M.P., Yaron, O., Huang, Q., Ding, L., Haley, D.A., Stewart, P.L., Horwitz, J. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. The 150th anniversary of the first depiction of the lesions of multiple sclerosis. Compston, A. J. Neurol. Neurosurg. Psychiatr. (1988) [Pubmed]
  3. Bromocriptine mesylate (Parlodel) in the management of amenorrhea/galactorrhea associated with hyperprolactinemia. Cuellar, F.G. Obstetrics and gynecology. (1980) [Pubmed]
  4. The snail host of schistosomiasis in São Tomé. Brown, D.S., Gracio, M.A., Moore, P.J., Rollinson, D., Romero, R., Southgate, V.R. Trans. R. Soc. Trop. Med. Hyg. (1989) [Pubmed]
  5. Elephantiasis in São Tomé and Príncipe. Ruiz, L., Campo, E., Corachán, M. Acta Trop. (1994) [Pubmed]
  6. Tome-1, wee1, and the onset of mitosis: coupled destruction for timely entry. Lim, H.H., Surana, U. Mol. Cell (2003) [Pubmed]
  7. Gathering no moss. Davies, J. Annu. Rev. Microbiol. (2003) [Pubmed]
  8. Cell-cycle-dependent regulation of the human and mouse Tome-1 promoters. Yoshida, K. FEBS Lett. (2005) [Pubmed]
  9. A fine-cut technique for permanent laryngeal sectioning. Roy, S., Lundy, D.S., Marcillo, A.S., Casiano, R.R. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (2001) [Pubmed]
  10. Complete median nerve transection as a complication of carpal tunnel release with a carpal tunnel tome. Chapman, C.B., Ristic, S., Rosenwasser, M.P. Am J. Orthop. (2001) [Pubmed]
  11. Microsatellite variation and evolution of human lactase persistence. Coelho, M., Luiselli, D., Bertorelle, G., Lopes, A.I., Seixas, S., Destro-Bisol, G., Rocha, J. Hum. Genet. (2005) [Pubmed]
  12. Phylogeography of Mabuya maculilabris (Reptilia) from São Tomé Island (Gulf of Guinea) inferred from mtDNA sequences. Jesus, J., Harris, D.J., Brehm, A. Mol. Phylogenet. Evol. (2005) [Pubmed]
  13. Absorbed doses from spiral CT and conventional spiral tomography: a phantom vs. cadaver study. Bou Serhal, C., Jacobs, R., Gijbels, F., Bosmans, H., Hermans, R., Quirynen, M., van Steenberghe, D. Clinical oral implants research. (2001) [Pubmed]
  14. Actions of prostaglandins on isolated perfused cat coronary arteries. Ogletree, M.L., Smith, J.B., Lefer, A.M. Am. J. Physiol. (1978) [Pubmed]
  15. Composition of the Essential Oils of Ocimum canum, O. gratissimum and O. minimum. Martins, A.P., Salgueiro, L.R., Vila, R., Tomi, F., Cañigueral, S., Casanova, J., da Cunha, A.P., Adzet, T. Planta Med. (1999) [Pubmed]
  16. Plasmodium falciparum chloroquine and quinine sensitivity in asymptomatic and symptomatic children in São Tomé Island. Baptista, J.L., Das Neves, I., D'Alessandro, U., Hendrix, L., Wéry, M. Trop. Med. Int. Health (1997) [Pubmed]
  17. The peopling of São Tomé (Gulf of Guinea): origins of slave settlers and admixture with the Portuguese. Tomás, G., Seco, L., Seixas, S., Faustino, P., Lavinha, J., Rocha, J. Hum. Biol. (2002) [Pubmed]
  18. Haplotype analysis of the apolipoprotein E and apolipoprotein C1 loci in Portugal and São Tomé e Príncipe (Gulf of Guinea): linkage disequilibrium evidence that APOE*4 is the ancestral APOE allele. Seixas, S., Trovoada, M.J., Rocha, J. Hum. Biol. (1999) [Pubmed]
  19. Histological alterations after irradiation of cartilage using Ho:YAG laser. Atik, O.S., Erdogan, D., Omeroglu, S., Korkusuz, F., Uslu, M.M., Eksioglu, F. Journal of clinical laser medicine & surgery. (2003) [Pubmed]
  20. Malaria in São Tomé and Príncipe: parasite prevalences and vector densities. Pinto, J., Sousa, C.A., Gil, V., Ferreira, C., Gonçalves, L., Lopes, D., Petrarca, V., Charlwood, J.D., do Rosário, V.E. Acta Trop. (2000) [Pubmed]
  21. Comparative dose measurements by spiral tomography for preimplant diagnosis: the Scanora machine versus the Cranex Tome radiography unit. Dula, K., Mini, R., van der Stelt, P.F., Sanderink, G.C., Schneeberger, P., Buser, D. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. (2001) [Pubmed]
  22. Antimalarial activity of extracts and alkaloids isolated from six plants used in traditional medicine in Mali and Sao Tome. Ancolio, C., Azas, N., Mahiou, V., Ollivier, E., Di Giorgio, C., Keita, A., Timon-David, P., Balansard, G. Phytotherapy research : PTR. (2002) [Pubmed]
 
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