Disease relevance of ATLIG4

• Recently, we showed that a yeast lig4 mutant is deficient in Agrobacterium T-DNA integration [1].

High impact information on ATLIG4

• Yeast two-hybrid analysis demonstrated a strong interaction between A. thaliana DNA ligase IV and the A. thaliana homologue of the human DNA ligase IV-binding protein XRCC4 [2].
• However, mutant seedlings were hypersensitive to the DNA-damaging agents methyl methanesulfonate and X-rays, demonstrating that AtLIG4 is required for the repair of DNA damage [1].

Biological context of ATLIG4

• The Arabidopsis AtLIG4 gene is required for the repair of DNA damage, but not for the integration of Agrobacterium T-DNA [1].

Physical interactions of ATLIG4

• Arabidopsis DNA ligase IV is induced by gamma-irradiation and interacts with an Arabidopsis homologue of the double strand break repair protein XRCC4 [2].

References