Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

ML1 - MEI2-like protein 1

Arabidopsis thaliana

Synonyms: AML1, At5g61960, K22G18.10, K22G18.9, K22G18_10, ...

Anderson, G.H. et al., Kaur, J. et al., Hirayama, T. et al.

Anderson, Hanson, Hirayama, Ishida, Kuromori, Obata, Shimoda, Yamamoto, Shinozaki, Ohto,

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Disease relevance of AML1

Functional analysis using RNA interference (RNAi) and combinations of insertion alleles revealed a role for the AML genes in meiosis, with RNAi lines and specific multiple mutant combinations displaying sterility and a range of defects in meiotic chromosome behavior [1].

High impact information on AML1

Analysis of AML1-AML5 expression at the cellular level indicated a closely similar expression pattern [1].
The Arabidopsis-mei2-Like (AML) genes comprise a five-member gene family related to the mei2 gene, which is a master regulator of meiosis in Schizosaccharomyces pombe and encodes an RNA binding protein [1].
This interaction is mediated by the N-terminal 219 residues of AML1, and marks AML1 as a candidate AtTOR kinase substrate in plants [2].
RESULTS: AtRaptor1B, a plant Raptor homologue, binds the AML1 (Arabidopsis Mei2-like 1) protein in a yeast two-hybrid assay [2].
The AML1 N-terminus additionally carries transcriptional activation domain activity [2].

Biological context of AML1

CONCLUSION: AML1 interacts with AtRaptor1B, homologue of a protein that recruits substrates for phosphorylation by the major cell-growth regulator TOR [2].
We have analyzed the AML genes to assess their role in plant meiosis and development [1].

Anatomical context of AML1

The Arabidopsis Mei2 homologue AML1 binds AtRaptor1B, the plant homologue of a major regulator of eukaryotic cell growth [2].

Other interactions of AML1

Identification of AML1 as a putative downstream effector of TOR gives valuable insights into the plant-specific mode of action of this critical growth regulator [2].

Analytical, diagnostic and therapeutic context of AML1

Northern blot analysis showed that the AML1 gene is expressed in each organ [3].

References

The Arabidopsis-mei2-like genes play a role in meiosis and vegetative growth in Arabidopsis. Kaur, J., Sebastian, J., Siddiqi, I. Plant Cell (2006) [Pubmed]
The Arabidopsis Mei2 homologue AML1 binds AtRaptor1B, the plant homologue of a major regulator of eukaryotic cell growth. Anderson, G.H., Hanson, M.R. BMC Plant Biol. (2005) [Pubmed]
Functional cloning of a cDNA encoding Mei2-like protein from Arabidopsis thaliana using a fission yeast pheromone receptor deficient mutant. Hirayama, T., Ishida, C., Kuromori, T., Obata, S., Shimoda, C., Yamamoto, M., Shinozaki, K., Ohto, C. FEBS Lett. (1997) [Pubmed]

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