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DYNLRB1  -  dynein, light chain, roadblock-type 1

Homo sapiens

Synonyms: BITH, BLP, Bithoraxoid-like protein, DNCL2A, DNLC2A, ...
 
 
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Disease relevance of DYNLRB1

  • Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients [1].
  • Postnatal administration of anti-BLP antibody attenuated clinical and pathological evidence of chronic lung disease in the hyperoxic baboon model [2].
  • Recently, CD10/NEP was found to hydrolyze bombesin-like peptides (BLP), which are mitogens for normal bronchial epithelial cells and small cell lung carcinomas [3].
  • We now demonstrate hyperplasia of both neuroendocrine cells and mast cells in lungs of baboons with BPD, compared with non-BPD controls or BLP antibody-treated BPD baboons [4].
  • Small cell lung cancer (SCLC) cells express and secrete bombesin-like peptides (BLP) that can activate specific receptors that stimulate the growth of these cells [5].
 

High impact information on DYNLRB1

  • Similar elevations in urine BLP were observed in the 125-d baboon "interrupted gestation" model of BPD [2].
  • Urine BLP levels increased soon after birth only in 100% O2-treated 140-d animals which developed BPD, correlating closely with severity of subsequent chronic lung disease [2].
  • However, not all smokers with increased expired air content of carbon monoxide exhibited increased BLP levels [6].
  • With this method we found that diabetic lens proteins produced more pentosidine on BLP than did aged lens proteins [7].
  • These data are a first evidence for the role of BLP in the regulation of DC maturation and function, demonstrating that BLP inhibit DC maturation and longevity in the lung cancer microenvironment [8].
 

Chemical compound and disease context of DYNLRB1

  • Twelve strains of Nocardia asteroides were studied for their susceptibility to 21 beta-lactam antibiotics, alone or in combination with clavulanic acid, sulbactam, or BLP 2013, and for their content of beta-lactamase [9].
  • In spite of a good correlation with the simpler oxygen consumption method for measuring hypoxanthine, there was no clear discrimination between hypoxic and well oxygenated infants, although mean concentrations were higher in infants with well defined criteria of intrapartum hypoxia or bith asphyxia, there was overlap with the normal range [10].
 

Biological context of DYNLRB1

 

Anatomical context of DYNLRB1

  • The DNLC2A was expressed in 12 of 16 human tissues examined, with especially strong expression in heart, liver and brain, whereas there was weak expression in lung, prostate, testis, small intestine and colon [1].
  • We examined the expression of BLP immunostaining in pulmonary neuroendocrine cells (PNEC), and in clusters of these cells called neuroepithelial bodies (NEB), in the lungs of three groups of infants: patients with CDH, newborns with lung hypoplasia due to other causes, and control subjects without lung abnormalities [14].
  • Degenerate PCR primers were designed to amplify all known BLP receptors and yielded products from 19/20 small cell lung carcinoma (SCLC) and 12/13 non-small cell lung carcinoma (NSCLC) cell lines [15].
  • 1. Inotropic effects of potassium rich solutions on frog cardiac muscle have been studied bith in current clamp and voltage clamp conditions, using a double sucrose gap apparatus [16].
  • This case is interesting in view of a previous case report of the association of anophthalmia and a germ-cell tumor (teratoma), and suggests a possible causal relationship between this malformation and germ-cell neoplasms, bith of which probably arise early in development [17].
 

Associations of DYNLRB1 with chemical compounds

  • When these two variables were excluded, identifiable differences in bith weight between cocaine and control mothers were no longer present [18].
  • The highest mean BLP levels were documented in BPD infants under age 3 months (882 fmol/mg creatinine), in controls between 3 and 12 months of age (625 fmol/mg creatinine), and in 12-60-month-old CF subjects (486 fmol/mg creatinine) [19].
  • RESULTS: Of the total, 38 (13.5%) strains produced beta-lactamase (BLP), 56 (19.9%) strains were beta-lactamase non-producing, ampicillin resistant (BLNAR) [20].
  • Taken together, these results are in agreement with the notion that ABeta and oxidized BLP can synergistically enhance oxidative damage in neurons and antioxidants such as resveratrol can ameliorate these damages [21].
 

Regulatory relationships of DYNLRB1

  • It was revealed that DNLC2A was up-regulated (45 out of the 68 cases) while DNLC2B was down-regulated (44 out of 68 cases), compared with their adjacent tumor-free liver tissues [1].
 

Analytical, diagnostic and therapeutic context of DYNLRB1

References

  1. Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients. Jiang, J., Yu, L., Huang, X., Chen, X., Li, D., Zhang, Y., Tang, L., Zhao, S. Gene (2001) [Pubmed]
  2. Bombesin-like peptide mediates lung injury in a baboon model of bronchopulmonary dysplasia. Sunday, M.E., Yoder, B.A., Cuttitta, F., Haley, K.J., Emanuel, R.L. J. Clin. Invest. (1998) [Pubmed]
  3. CD10/neutral endopeptidase 24.11 in developing human fetal lung. Patterns of expression and modulation of peptide-mediated proliferation. Sunday, M.E., Hua, J., Torday, J.S., Reyes, B., Shipp, M.A. J. Clin. Invest. (1992) [Pubmed]
  4. Bombesin-like peptides and mast cell responses: relevance to bronchopulmonary dysplasia? Subramaniam, M., Sugiyama, K., Coy, D.H., Kong, Y., Miller, Y.E., Weller, P.F., Wada, K., Wada, E., Sunday, M.E. Am. J. Respir. Crit. Care Med. (2003) [Pubmed]
  5. Phase I and imaging trial of a monoclonal antibody directed against gastrin-releasing peptide in patients with lung cancer. Chaudhry, A., Carrasquillo, J.A., Avis, I.L., Shuke, N., Reynolds, J.C., Bartholomew, R., Larson, S.M., Cuttitta, F., Johnson, B.E., Mulshine, J.L. Clin. Cancer Res. (1999) [Pubmed]
  6. Urinary levels of bombesin-like peptides in asymptomatic cigarette smokers: a potential risk marker for smoking-related diseases. Aguayo, S.M., King, T.E., Kane, M.A., Sherritt, K.M., Silvers, W., Nett, L.M., Petty, T.L., Miller, Y.E. Cancer Res. (1992) [Pubmed]
  7. Early glycation products produce pentosidine cross-links on native proteins. novel mechanism of pentosidine formation and propagation of glycation. Chellan, P., Nagaraj, R.H. J. Biol. Chem. (2001) [Pubmed]
  8. Lung cancer-derived bombesin-like peptides down-regulate the generation and function of human dendritic cells. Makarenkova, V.P., Shurin, G.V., Tourkova, I.L., Balkir, L., Pirtskhalaishvili, G., Perez, L., Gerein, V., Siegfried, J.M., Shurin, M.R. J. Neuroimmunol. (2003) [Pubmed]
  9. In-vitro susceptibility of Nocardia asteroides to 21 beta-lactam antibiotics, in combination with three beta-lactamase inhibitors, and its relationship to the beta-lactamase content. Kitzis, M.D., Gutmann, L., Acar, J.F. J. Antimicrob. Chemother. (1985) [Pubmed]
  10. The measurement of hypoxanthine, xanthine, inosine and uridine in umbilical cord blood and fetal scalp blood samples as a measure of fetal hypoxia. O'Connor, M.C., Harkness, R.A., Simmonds, R.J., Hytten, F.E. British journal of obstetrics and gynaecology. (1981) [Pubmed]
  11. Identification of intrauterine growth retardation among low birth weight preterm infants. Yogman, M.W., Kraemer, H.C., Kindlon, D., Tyson, J.E., Casey, P., Gross, R.T. J. Pediatr. (1989) [Pubmed]
  12. Frequency of phenylketonuria in Norway. Saugstad, L.F. Clin. Genet. (1975) [Pubmed]
  13. Immunomodulatory functions of the diffuse neuroendocrine system: implications for bronchopulmonary dysplasia. Sunday, M.E., Shan, L., Subramaniam, M. Endocr. Pathol. (2004) [Pubmed]
  14. Abnormal expression of pulmonary bombesin-like peptide immunostaining cells in infants with congenital diaphragmatic hernia. Ijsselstijn, H., Gaillard, J.L., de Jongste, J.C., Tibboel, D., Cutz, E. Pediatr. Res. (1997) [Pubmed]
  15. Clinical correlates of bombesin-like peptide receptor subtype expression in human lung cancer cells. Toi-Scott, M., Jones, C.L., Kane, M.A. Lung Cancer (1996) [Pubmed]
  16. Inotropic effects of potassium rich solutions of frog cardiac muscles. Bonvallet, R., Ildefonse, M., Roche, M., Rougier, O. Pflugers Arch. (1981) [Pubmed]
  17. Congenital anophthalmia associated with intracranial germinoma. Bachman, D.S., Kosnik, E.J., Boesel, C.P., Sotos, J.F. Developmental medicine and child neurology. (1980) [Pubmed]
  18. A case-control study of cocaine use in pregnancy. Miller, J.M., Boudreaux, M.C., Regan, F.A. Am. J. Obstet. Gynecol. (1995) [Pubmed]
  19. Urinary bombesin-like peptide levels in infants and children with bronchopulmonary dysplasia and cystic fibrosis. Scher, H., Miller, Y.E., Aguayo, S.M., Johnson, K.J., Miller, J.E., McCray, P.B. Pediatr. Pulmonol. (1998) [Pubmed]
  20. Antimicrobial susceptibility of respiratory Haemophilus influenzae strains isolated from pediatric respiratory tract infections. Cao, L.D., Naruhiko, I., Nobue, T., Yoichi, K. Pediatrics international : official journal of the Japan Pediatric Society. (2004) [Pubmed]
  21. Oxidized lipoproteins, beta amyloid peptides and Alzheimer's disease. Sun, A.Y., Draczynska-Lusiak, B., Sun, G.Y. Neurotoxicity research. (2001) [Pubmed]
  22. Increased levels of bombesin-like peptides in the lower respiratory tract of asymptomatic cigarette smokers. Aguayo, S.M., Kane, M.A., King, T.E., Schwarz, M.I., Grauer, L., Miller, Y.E. J. Clin. Invest. (1989) [Pubmed]
 
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