Gene Review:
ITCH - itchy E3 ubiquitin protein ligase
Homo sapiens
Synonyms:
ADMFD, AIF4, AIP4, Atrophin-1-interacting protein 4, E3 ubiquitin-protein ligase Itchy homolog, ...
- HECT ubiquitin ligases link viral and cellular PPXY motifs to the vacuolar protein-sorting pathway. Martin-Serrano, J., Eastman, S.W., Chung, W., Bieniasz, P.D. J. Cell Biol. (2005)
- Regulatory networks induced by live parasites impair both Th1 and Th2 pathways in patent lymphatic filariasis: implications for parasite persistence. Babu, S., Blauvelt, C.P., Kumaraswami, V., Nutman, T.B. J. Immunol. (2006)
- Leukotriene D4 and E4 induce transmembrane signaling in human epithelial cells. Single cell analysis reveals diverse pathways at the G-protein level for the influx and the intracellular mobilization of Ca2+. Sjölander, A., Grönroos, E., Hammarström, S., Andersson, T. J. Biol. Chem. (1990)
- Contact sensitivity to NAPP printing plates secondary to a relapsing hand dermatitis. Wahlberg, J.E. Contact Derm. (1983)
- Impact of efalizumab on psoriasis-specific patient-reported outcomes. Results from three randomized, placebo-controlled clinical trials of moderate to severe plaque psoriasis. Menter, A., Kosinski, M., Bresnahan, B.W., Papp, K.A., Ware, J.E. Journal of drugs in dermatology : JDD. (2004)
- Characterisation of the associations and impact of symptoms in primary biliary cirrhosis using a disease specific quality of life measure. Newton, J.L., Bhala, N., Burt, J., Jones, D.E. J. Hepatol. (2006)
- Psychosomatic cofactors and psychiatric comorbidity in patients with chronic itch. Schneider, G., Driesch, G., Heuft, G., Evers, S., Luger, T.A., St??nder, S. Clin. Exp. Dermatol. (2006)
- Ubiquitin ligases and the immune response. Liu, Y.C. Annu. Rev. Immunol. (2004)
- The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice. Perry, W.L., Hustad, C.M., Swing, D.A., O'Sullivan, T.N., Jenkins, N.A., Copeland, N.G. Nat. Genet. (1998)
- Structure of ADP x AIF4(-)-stabilized nitrogenase complex and its implications for signal transduction. Schindelin, H., Kisker, C., Schlessman, J.L., Howard, J.B., Rees, D.C. Nature (1997)
- Formation of a transition-state analog of the Ras GTPase reaction by Ras-GDP, tetrafluoroaluminate, and GTPase-activating proteins. Mittal, R., Ahmadian, M.R., Goody, R.S., Wittinghofer, A. Science (1996)
- E3 ubiquitin ligases as T cell anergy factors. Mueller, D.L. Nat. Immunol. (2004)
- Atrophin-1-interacting protein 4/human Itch is a ubiquitin E3 ligase for human enhancer of filamentation 1 in transforming growth factor-beta signaling pathways. Feng, L., Guedes, S., Wang, T. J. Biol. Chem. (2004)
- Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH. Courbard, J.R., Fiore, F., Adélaïde, J., Borg, J.P., Birnbaum, D., Ollendorff, V. J. Biol. Chem. (2002)
- Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination. Marcotullio, L.D., Ferretti, E., Greco, A., De Smaele, E., Po, A., Sico, M.A., Alimandi, M., Giannini, G., Maroder, M., Screpanti, I., Gulino, A. Nat. Cell Biol. (2006)
- The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4. Marchese, A., Raiborg, C., Santini, F., Keen, J.H., Stenmark, H., Benovic, J.L. Dev. Cell (2003)
- The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels. Wegierski, T., Hill, K., Schaefer, M., Walz, G. EMBO J. (2006)
- Human ITCH is a coregulator of the hematopoietic transcription factor NF-E2. Chen, X., Wen, S., Fukuda, M.N., Gavva, N.R., Hsu, D., Akama, T.O., Yang-Feng, T., Shen, C.K. Genomics (2001)
- Ubiquitin-mediated fluorescence complementation reveals that Jun ubiquitinated by Itch/AIP4 is localized to lysosomes. Fang, D., Kerppola, T.K. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains. Chastagner, P., Isra??l, A., Brou, C. EMBO Rep. (2006)
- Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase. Qiu, L., Joazeiro, C., Fang, N., Wang, H.Y., Elly, C., Altman, Y., Fang, D., Hunter, T., Liu, Y.C. J. Biol. Chem. (2000)
- Multiple trimeric G-proteins on the trans-Golgi network exert stimulatory and inhibitory effects on secretory vesicle formation. Leyte, A., Barr, F.A., Kehlenbach, R.H., Huttner, W.B. EMBO J. (1992)
- Identification of M-channels in outside-out patches excised from sympathetic ganglion cells. Stansfeld, C.E., Marsh, S.J., Gibb, A.J., Brown, D.A. Neuron (1993)
- Quality control in the secretory pathway: retention of a misfolded viral membrane glycoprotein involves cycling between the ER, intermediate compartment, and Golgi apparatus. Hammond, C., Helenius, A. J. Cell Biol. (1994)
- Tyrosine kinase-activating growth factors potentiate thrombin- and AIF4- -induced phosphoinositide breakdown in hamster fibroblasts. Evidence for positive cross-talk between the two mitogenic signaling pathways. Paris, S., Chambard, J.C., Pouysségur, J. J. Biol. Chem. (1988)
- An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein. Li, H., Seth, A. Oncogene (2004)
- A regulatory circuit controlling Itch-mediated p73 degradation by Runx. Levy, D., Reuven, N., Shaul, Y. J. Biol. Chem. (2008)
- CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4. Slagsvold, T., Marchese, A., Brech, A., Stenmark, H. EMBO J. (2006)
- AIP4 restricts transforming growth factor-beta signaling through a ubiquitination-independent mechanism. Lallemand, F., Seo, S.R., Ferrand, N., Pessah, M., L'Hoste, S., Rawadi, G., Roman-Roman, S., Camonis, J., Atfi, A. J. Biol. Chem. (2005)
- Ubiquitylation of a melanosomal protein by HECT-E3 ligases serves as sorting signal for lysosomal degradation. Lévy, F., Muehlethaler, K., Salvi, S., Peitrequin, A.L., Lindholm, C.K., Cerottini, J.C., Rimoldi, D. Mol. Biol. Cell (2005)
- The RING-H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases. Kitching, R., Wong, M.J., Koehler, D., Burger, A.M., Landberg, G., Gish, G., Seth, A. Biochim. Biophys. Acta (2003)
- Effects of nicotine on the immune response. II. Chronic nicotine treatment induces T cell anergy. Geng, Y., Savage, S.M., Razani-Boroujerdi, S., Sopori, M.L. J. Immunol. (1996)
- Electrical Ear Acupuncture Reduces Histamine-induced Itch (Alloknesis). Kesting, M.R., Thurmueller, P., Hölzle, F., Wolff, K.D., Holland-Letz, T., Stücker, M. Acta Derm. Venereol. (2006)
- A versatile system for site-specific enzymatic biotinylation and regulated expression of proteins in cultured mammalian cells. Kulman, J.D., Satake, M., Harris, J.E. Protein Expr. Purif. (2007)