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MRP1  -  glutathione S-conjugate transporting ATPase

Arabidopsis thaliana

Synonyms: ABCC1, ARABIDOPSIS THALIANA MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1, ATABCC1, ATMRP1, ATP-binding cassette C1, ...
 
 
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Disease relevance of ATMRP1

  • All are members of the multidrug resistance-associated protein (MRP)/cystic fibrosis transmembrane conductance regulator (CFTR) subfamily of ATP-binding cassette (ABC) transporters [1].
 

High impact information on ATMRP1

  • AtMRP2, an Arabidopsis ATP binding cassette transporter able to transport glutathione S-conjugates and chlorophyll catabolites: functional comparisons with Atmrp1 [2].
  • AtMRP1 gene of Arabidopsis encodes a glutathione S-conjugate pump: isolation and functional definition of a plant ATP-binding cassette transporter gene [3].
  • We show here that a transporter responsible for the removal of glutathione S-conjugates from the cytosol, a specific Mg2+-ATPase, is encoded by the AtMRP1 gene of Arabidopsis thaliana [3].
  • The sequence of AtMRP1 and the transport capabilities of membranes prepared from yeast cells transformed with plasmid-borne AtMRP1 demonstrate that this gene encodes an ATP-binding cassette transporter competent in the transport of glutathione S-conjugates of xenobiotics and endogenous substances, including herbicides and anthocyanins [3].
  • Unlike AtPGP1, AtMRP1 binds to the C-terminal tetratricopeptide repeat domain of TWD1, which is well known to mediate protein-protein interactions [4].
 

Biological context of ATMRP1

  • ABC transporters from the multidrug resistance-associated protein (MRP) subfamily are glutathione S-conjugate pumps exhibiting a broad substrate specificity illustrated by numerous xenobiotics, such as anticancer drugs, herbicides, pesticides and heavy metals [5].
 

Anatomical context of ATMRP1

  • We were able to demonstrate that TWD1 binds to isolated vacuoles and has a significant impact on the uptake of metolachlor-GS and estradiol-beta-glucuronide, well-known substrates of vacuolar transporters AtMRP1 and AtMRP2 [4].
  • Expression of MRP1 at the plasma membrane was correlated with an increase in the MCPs resistance to Sb(III) and a limitation of the metalloid content in the protoplasts due to an improvement in Sb(III) efflux [5].
 

Associations of ATMRP1 with chemical compounds

  • Moreover, Sb(III) transport was sensitive to classical inhibitors of the human MRP1, such as MK571 or glibenclamide [5].
  • In order to investigate the functionality of MRP1 in Arabidopsis, mesophyll cell protoplasts (MCPs) were isolated from transgenic plants and transport activities were measured by using calcein or Sb(III) as substrates [5].
 

Other interactions of ATMRP1

References

  1. An ATP-binding cassette transporter related to yeast vacuolar ScYCF1 is important for Cd sequestration in Chlamydomonas reinhardtii. Wang, T., Wu, M. Plant Cell Environ. (2006) [Pubmed]
  2. AtMRP2, an Arabidopsis ATP binding cassette transporter able to transport glutathione S-conjugates and chlorophyll catabolites: functional comparisons with Atmrp1. Lu, Y.P., Li, Z.S., Drozdowicz, Y.M., Hortensteiner, S., Martinoia, E., Rea, P.A. Plant Cell (1998) [Pubmed]
  3. AtMRP1 gene of Arabidopsis encodes a glutathione S-conjugate pump: isolation and functional definition of a plant ATP-binding cassette transporter gene. Lu, Y.P., Li, Z.S., Rea, P.A. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  4. Arabidopsis immunophilin-like TWD1 functionally interacts with vacuolar ABC transporters. Geisler, M., Girin, M., Brandt, S., Vincenzetti, V., Plaza, S., Paris, N., Kobae, Y., Maeshima, M., Billion, K., Kolukisaoglu, U.H., Schulz, B., Martinoia, E. Mol. Biol. Cell (2004) [Pubmed]
  5. Transport of antimony salts by Arabidopsis thaliana protoplasts over-expressing the human multidrug resistance-associated protein 1 (MRP1/ABCC1). Gayet, L., Picault, N., Cazal??, A.C., Beyly, A., Lucas, P., Jacquet, H., Suso, H.P., Vavasseur, A., Peltier, G., Forestier, C. FEBS Lett. (2006) [Pubmed]
 
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