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Gene Review: 

ZDHHC16  -  zinc finger, DHHC-type containing 16

Homo sapiens

Synonyms: APH2, DHHC-16, UNQ2570/PRO6258, Zinc finger DHHC domain-containing protein 16
 
 
 
 
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High impact information on ZDHHC16

  • Bioinformatics analysis revealed hAPH2 protein shares 96% identity with mouse APH2 and contains a zf-DHHC domain (148-210aa), which is always involved in protein-protein or protein-DNA interaction [1].
  • Fused with GFP and expressed in COS-7, NIH/3T3 and SMMC-7721 cell lines, hAPH2 showed predominant distribution in the cytoplasm and co-localized with JAB1 around the nucleus [1].
 

Analytical, diagnostic and therapeutic context of ZDHHC16

References

  1. Molecular cloning and characterization of human Aph2 gene, involved in AP-1 regulation by interaction with JAB1. Zhang, F., Di, Y., Li, J., Shi, Y., Zhang, L., Wang, C., He, X., Liu, Y., Wan, D., Huo, K., Gu, J. Biochim. Biophys. Acta (2006) [Pubmed]
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