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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review

GTPBP3  -  GTP binding protein 3 (mitochondrial)

Homo sapiens

Synonyms: FLJ14700, GTP-binding protein 3, GTPBG3, MSS1, MTGP1, ...
 
 
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Disease relevance of GTPBP3

 

High impact information on GTPBP3

  • Functional conservation of this protein is supported by the observation that isolated human GTPBP3 cDNA can complement the respiratory-deficient phenotype of yeast mss1 cells carrying P(R)(454) mutation [2].
  • We showed that Gtpbp3 localizes in mitochondrion [2].
  • These results show that HEC is a negative regulator of MSS1 and suggest that it may modulate M phase progression, in part, through the regulation of proteasome-mediated degradation of cell cycle regulatory proteins [3].
  • Both cytosol and membrane-associated forms of MTGP were analyzed, and each was phenotyped by reference to isoelectric point and buoyant density [1].
  • Characteristics of membrane and cytosol forms of the mammary tumor glycoprotein molecule MTGP in human breast carcinoma cell cultures and tumors [1].
 

Chemical compound and disease context of GTPBP3

 

Biological context of GTPBP3

  • The mouse GTPBP3 gene containing 9 exons encodes a 486 residue protein with a strong homology to the GTPBP3-like proteins of bacteria, yeast, and other homologs, related to tRNA modification [4].
  • HEC is not a part of the 26 S proteasome and interacts with MSS1 only when it is dissociated from the complex during M phase [3].
 

Other interactions of GTPBP3

  • Two genes, MTO1 and GTPBP3, showed strongly suggestive linkage and significant LD results [5].
 

Analytical, diagnostic and therapeutic context of GTPBP3

  • Each form of MTGP was homogeneous for a given single tumor or cell culture and retained its phenotypic features with passage and cloning [1].

References

 
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